Tumor necrosis factor-induced hepatic DNA fragmentation as an early marker of T cell-dependent liver injury in mice.
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Tumor necrosis factor-induced hepatic DNA fragmentation as an early marker of T cell-dependent liver injury in mice. / Gantner, F; Leist, M; Jilg, S; Germann, P G; Freudenberg, M A; Tiegs, Gisa.
in: GASTROENTEROLOGY, Jahrgang 109, Nr. 1, 1, 1995, S. 166-176.Publikationen: SCORING: Beitrag in Fachzeitschrift/Zeitung › SCORING: Zeitschriftenaufsatz › Forschung › Begutachtung
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TY - JOUR
T1 - Tumor necrosis factor-induced hepatic DNA fragmentation as an early marker of T cell-dependent liver injury in mice.
AU - Gantner, F
AU - Leist, M
AU - Jilg, S
AU - Germann, P G
AU - Freudenberg, M A
AU - Tiegs, Gisa
PY - 1995
Y1 - 1995
N2 - The injection of mice with anti-CD3 monoclonal antibody causes activation of T lymphocytes and leads to a lethal shock syndrome. The aim of this study was to investigate T cell-dependent, cytokine-mediated target cell death that leads to organ injury.
AB - The injection of mice with anti-CD3 monoclonal antibody causes activation of T lymphocytes and leads to a lethal shock syndrome. The aim of this study was to investigate T cell-dependent, cytokine-mediated target cell death that leads to organ injury.
KW - Animals
KW - Mice
KW - Mice, Inbred BALB C
KW - Mice, Inbred C57BL
KW - Apoptosis
KW - Lymphocyte Activation
KW - Mice, Nude
KW - Antigens, CD3/immunology
KW - Galactosamine/immunology
KW - Immunization
KW - Alanine Transaminase/blood
KW - Antibodies, Monoclonal/pharmacology
KW - T-Lymphocytes/immunology
KW - DNA Damage
KW - Enterotoxins/pharmacology
KW - Liver/enzymology/metabolism/pathology
KW - Liver Failure/immunology/metabolism/pathology
KW - Shock/immunology/metabolism/pathology
KW - Tumor Necrosis Factor-alpha/physiology
KW - Animals
KW - Mice
KW - Mice, Inbred BALB C
KW - Mice, Inbred C57BL
KW - Apoptosis
KW - Lymphocyte Activation
KW - Mice, Nude
KW - Antigens, CD3/immunology
KW - Galactosamine/immunology
KW - Immunization
KW - Alanine Transaminase/blood
KW - Antibodies, Monoclonal/pharmacology
KW - T-Lymphocytes/immunology
KW - DNA Damage
KW - Enterotoxins/pharmacology
KW - Liver/enzymology/metabolism/pathology
KW - Liver Failure/immunology/metabolism/pathology
KW - Shock/immunology/metabolism/pathology
KW - Tumor Necrosis Factor-alpha/physiology
M3 - SCORING: Journal article
VL - 109
SP - 166
EP - 176
JO - GASTROENTEROLOGY
JF - GASTROENTEROLOGY
SN - 0016-5085
IS - 1
M1 - 1
ER -