Tumor necrosis factor-induced hepatic DNA fragmentation as an early marker of T cell-dependent liver injury in mice.

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Tumor necrosis factor-induced hepatic DNA fragmentation as an early marker of T cell-dependent liver injury in mice. / Gantner, F; Leist, M; Jilg, S; Germann, P G; Freudenberg, M A; Tiegs, Gisa.

in: GASTROENTEROLOGY, Jahrgang 109, Nr. 1, 1, 1995, S. 166-176.

Publikationen: SCORING: Beitrag in Fachzeitschrift/ZeitungSCORING: ZeitschriftenaufsatzForschungBegutachtung

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Gantner F, Leist M, Jilg S, Germann PG, Freudenberg MA, Tiegs G. Tumor necrosis factor-induced hepatic DNA fragmentation as an early marker of T cell-dependent liver injury in mice. GASTROENTEROLOGY. 1995;109(1):166-176. 1.

Bibtex

@article{06c37cf91e5545c9818b4bd8ea93ce9d,
title = "Tumor necrosis factor-induced hepatic DNA fragmentation as an early marker of T cell-dependent liver injury in mice.",
abstract = "The injection of mice with anti-CD3 monoclonal antibody causes activation of T lymphocytes and leads to a lethal shock syndrome. The aim of this study was to investigate T cell-dependent, cytokine-mediated target cell death that leads to organ injury.",
keywords = "Animals, Mice, Mice, Inbred BALB C, Mice, Inbred C57BL, Apoptosis, Lymphocyte Activation, Mice, Nude, Antigens, CD3/immunology, Galactosamine/immunology, Immunization, Alanine Transaminase/blood, Antibodies, Monoclonal/pharmacology, T-Lymphocytes/*immunology, *DNA Damage, Enterotoxins/pharmacology, Liver/enzymology/*metabolism/pathology, Liver Failure/immunology/metabolism/*pathology, Shock/immunology/metabolism/pathology, *Tumor Necrosis Factor-alpha/physiology, Animals, Mice, Mice, Inbred BALB C, Mice, Inbred C57BL, Apoptosis, Lymphocyte Activation, Mice, Nude, Antigens, CD3/immunology, Galactosamine/immunology, Immunization, Alanine Transaminase/blood, Antibodies, Monoclonal/pharmacology, T-Lymphocytes/*immunology, *DNA Damage, Enterotoxins/pharmacology, Liver/enzymology/*metabolism/pathology, Liver Failure/immunology/metabolism/*pathology, Shock/immunology/metabolism/pathology, *Tumor Necrosis Factor-alpha/physiology",
author = "F Gantner and M Leist and S Jilg and Germann, {P G} and Freudenberg, {M A} and Gisa Tiegs",
year = "1995",
language = "English",
volume = "109",
pages = "166--176",
journal = "GASTROENTEROLOGY",
issn = "0016-5085",
publisher = "W.B. Saunders Ltd",
number = "1",

}

RIS

TY - JOUR

T1 - Tumor necrosis factor-induced hepatic DNA fragmentation as an early marker of T cell-dependent liver injury in mice.

AU - Gantner, F

AU - Leist, M

AU - Jilg, S

AU - Germann, P G

AU - Freudenberg, M A

AU - Tiegs, Gisa

PY - 1995

Y1 - 1995

N2 - The injection of mice with anti-CD3 monoclonal antibody causes activation of T lymphocytes and leads to a lethal shock syndrome. The aim of this study was to investigate T cell-dependent, cytokine-mediated target cell death that leads to organ injury.

AB - The injection of mice with anti-CD3 monoclonal antibody causes activation of T lymphocytes and leads to a lethal shock syndrome. The aim of this study was to investigate T cell-dependent, cytokine-mediated target cell death that leads to organ injury.

KW - Animals

KW - Mice

KW - Mice, Inbred BALB C

KW - Mice, Inbred C57BL

KW - Apoptosis

KW - Lymphocyte Activation

KW - Mice, Nude

KW - Antigens, CD3/immunology

KW - Galactosamine/immunology

KW - Immunization

KW - Alanine Transaminase/blood

KW - Antibodies, Monoclonal/pharmacology

KW - T-Lymphocytes/immunology

KW - DNA Damage

KW - Enterotoxins/pharmacology

KW - Liver/enzymology/metabolism/pathology

KW - Liver Failure/immunology/metabolism/pathology

KW - Shock/immunology/metabolism/pathology

KW - Tumor Necrosis Factor-alpha/physiology

KW - Animals

KW - Mice

KW - Mice, Inbred BALB C

KW - Mice, Inbred C57BL

KW - Apoptosis

KW - Lymphocyte Activation

KW - Mice, Nude

KW - Antigens, CD3/immunology

KW - Galactosamine/immunology

KW - Immunization

KW - Alanine Transaminase/blood

KW - Antibodies, Monoclonal/pharmacology

KW - T-Lymphocytes/immunology

KW - DNA Damage

KW - Enterotoxins/pharmacology

KW - Liver/enzymology/metabolism/pathology

KW - Liver Failure/immunology/metabolism/pathology

KW - Shock/immunology/metabolism/pathology

KW - Tumor Necrosis Factor-alpha/physiology

M3 - SCORING: Journal article

VL - 109

SP - 166

EP - 176

JO - GASTROENTEROLOGY

JF - GASTROENTEROLOGY

SN - 0016-5085

IS - 1

M1 - 1

ER -