Triaging Pap cytology negative, HPV positive cervical cancer screening results with p16/Ki-67 Dual-stained cytology.
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Triaging Pap cytology negative, HPV positive cervical cancer screening results with p16/Ki-67 Dual-stained cytology. / Petry, K Ulrich; Schmidt, Dietmar; Scherbring, Sarah; Luyten, Alexander; Reinecke-Lüthge, Axel; Bergeron, Christine; Kommoss, Friedrich; Löning, Thomas; Ordi, Jaume; Regauer, Sigrid; Ridder, Ruediger.
in: GYNECOL ONCOL, Jahrgang 121, Nr. 3, 3, 2011, S. 505-509.Publikationen: SCORING: Beitrag in Fachzeitschrift/Zeitung › SCORING: Zeitschriftenaufsatz › Forschung › Begutachtung
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TY - JOUR
T1 - Triaging Pap cytology negative, HPV positive cervical cancer screening results with p16/Ki-67 Dual-stained cytology.
AU - Petry, K Ulrich
AU - Schmidt, Dietmar
AU - Scherbring, Sarah
AU - Luyten, Alexander
AU - Reinecke-Lüthge, Axel
AU - Bergeron, Christine
AU - Kommoss, Friedrich
AU - Löning, Thomas
AU - Ordi, Jaume
AU - Regauer, Sigrid
AU - Ridder, Ruediger
PY - 2011
Y1 - 2011
N2 - Testing for human papillomavirus (HPV) has been shown to increase the sensitivity and negative predictive value for detection of high-grade cervical intraepithelial neoplasia (CIN2+), either when used in conjunction with Pap cytology testing or alone. However, there is no satisfying clinical management algorithm for women testing Pap negative/HPV positive. We therefore evaluated the clinical utility of a novel dual biomarker-based approach (p16/Ki-67 Dual-stained cytology) for the identification of CIN2+ in women with Pap negative/HPV positive screening results, without the need to refer all women to immediate colposcopy.
AB - Testing for human papillomavirus (HPV) has been shown to increase the sensitivity and negative predictive value for detection of high-grade cervical intraepithelial neoplasia (CIN2+), either when used in conjunction with Pap cytology testing or alone. However, there is no satisfying clinical management algorithm for women testing Pap negative/HPV positive. We therefore evaluated the clinical utility of a novel dual biomarker-based approach (p16/Ki-67 Dual-stained cytology) for the identification of CIN2+ in women with Pap negative/HPV positive screening results, without the need to refer all women to immediate colposcopy.
KW - Adult
KW - Humans
KW - Aged
KW - Female
KW - Middle Aged
KW - Aged, 80 and over
KW - Cohort Studies
KW - Sensitivity and Specificity
KW - Vaginal Smears
KW - Neoplasm Proteins/metabolism
KW - Ki-67 Antigen/metabolism
KW - Staining and Labeling/methods
KW - Cervical Intraepithelial Neoplasia/metabolism/pathology/virology
KW - Papillomavirus Infections/metabolism/pathology/virology
KW - Uterine Cervical Neoplasms/metabolism/pathology/virology
KW - Adult
KW - Humans
KW - Aged
KW - Female
KW - Middle Aged
KW - Aged, 80 and over
KW - Cohort Studies
KW - Sensitivity and Specificity
KW - Vaginal Smears
KW - Neoplasm Proteins/metabolism
KW - Ki-67 Antigen/metabolism
KW - Staining and Labeling/methods
KW - Cervical Intraepithelial Neoplasia/metabolism/pathology/virology
KW - Papillomavirus Infections/metabolism/pathology/virology
KW - Uterine Cervical Neoplasms/metabolism/pathology/virology
M3 - SCORING: Journal article
VL - 121
SP - 505
EP - 509
JO - GYNECOL ONCOL
JF - GYNECOL ONCOL
SN - 0090-8258
IS - 3
M1 - 3
ER -