Treating progressive multifocal leukoencephalopathy with interleukin 7 and vaccination with JC virus capsid protein VP1

Mireia Sospedra; Sven Schippling; Sara Yousef; Ilijas Jelcic; Silvia Bofill-Mas; Raquel Planas; Jan-Patrick Stellmann; Viktoria Demina; Paola Cinque; Robert Garcea; Therese Croughs; Rosina Girones; Roland Martin

doi:10.1093/cid/ciu682

Treating progressive multifocal leukoencephalopathy with interleukin 7 and vaccination with JC virus capsid protein VP1

Mireia Sospedra
Sven Schippling
Sara Yousef
Ilijas Jelcic
Silvia Bofill-Mas
Raquel Planas
Jan-Patrick Stellmann
Viktoria Demina
Paola Cinque
Robert Garcea
Therese Croughs
Rosina Girones
Roland Martin

Beteiligte Einrichtungen

Institut für Neuroimmunologie und Multiple Sklerose

Abstract

Progressive multifocal leukoencephalopathy is a currently untreatable infection of the brain. Here, we demonstrate in 2 patients that treatment with interleukin 7, JC polyomavirus (JCV) capsid protein VP1, and a Toll-like receptor 7 agonist used as adjuvant, was well tolerated, and showed a very favorable safety profile and unexpected efficacy that warrant further investigation.

Bibliografische Daten

Originalsprache	Englisch
ISSN	1058-4838
DOIs	https://doi.org/10.1093/cid/ciu682
Status	Veröffentlicht - 01.12.2014

PubMed	25214510