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Transferrin ensures survival of ovarian carcinoma cells when apoptosis is induced by TNFalpha, FasL, TRAIL, or Myc

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Transferrin ensures survival of ovarian carcinoma cells when apoptosis is induced by TNFalpha, FasL, TRAIL, or Myc. / Fassl, Sandra; Leisser, Christina; Huettenbrenner, Simone; Maier, Susanne; Rosenberger, Georg; Strasser, Stephan; Grusch, Michael; Fuhrmann, Gerhard; Leuhuber, Katharina; Polgar, Doris; Stani, Josefine; Tichy, Brigitte; Nowotny, Christine; Krupitza, Georg.

in: ONCOGENE, Jahrgang 22, Nr. 51, 13.11.2003, S. 8343-55.

Publikationen: SCORING: Beitrag in Fachzeitschrift/Zeitung › SCORING: Zeitschriftenaufsatz › Forschung › Begutachtung

Harvard

Fassl, S, Leisser, C, Huettenbrenner, S, Maier, S, Rosenberger, G, Strasser, S, Grusch, M, Fuhrmann, G, Leuhuber, K, Polgar, D, Stani, J, Tichy, B, Nowotny, C & Krupitza, G 2003, 'Transferrin ensures survival of ovarian carcinoma cells when apoptosis is induced by TNFalpha, FasL, TRAIL, or Myc', ONCOGENE, Jg. 22, Nr. 51, S. 8343-55. https://doi.org/10.1038/sj.onc.1207047

APA

Fassl, S., Leisser, C., Huettenbrenner, S., Maier, S., Rosenberger, G., Strasser, S., Grusch, M., Fuhrmann, G., Leuhuber, K., Polgar, D., Stani, J., Tichy, B., Nowotny, C., & Krupitza, G. (2003). Transferrin ensures survival of ovarian carcinoma cells when apoptosis is induced by TNFalpha, FasL, TRAIL, or Myc. ONCOGENE, 22(51), 8343-55. https://doi.org/10.1038/sj.onc.1207047

Vancouver

Fassl S, Leisser C, Huettenbrenner S, Maier S, Rosenberger G, Strasser S et al. Transferrin ensures survival of ovarian carcinoma cells when apoptosis is induced by TNFalpha, FasL, TRAIL, or Myc. ONCOGENE. 2003 Nov 13;22(51):8343-55. https://doi.org/10.1038/sj.onc.1207047

Bibtex

@article{3ac80e4e78bc4c3f9bc36efae2c17e1a,
title = "Transferrin ensures survival of ovarian carcinoma cells when apoptosis is induced by TNFalpha, FasL, TRAIL, or Myc",
abstract = "The activation of Myc induces apoptosis of human ovarian adenocarcinoma N.1 cells when serum factors are limited. However, the downstream mechanism that is triggered by Myc is unknown. Myc-activation and treatment with the proapoptotic ligands TNFalpha, FasL, and TRAIL induced H-ferritin expression under serum-deprived conditions. H-ferritin chelates intracellular iron and also intracellular iron sequestration by deferoxamine-induced apoptosis of N.1 cells. Supplementation of serum-free medium with holo-transferrin blocked apoptosis of N.1 cells that was induced by Myc-activation or by treatment with TNFalpha, FasL, and TRAIL, whereas apotransferrin did not prevent apoptosis. This suggests that intracellular iron depletion was a trigger for apoptosis and that transferrin-bound iron rescued N.1 cells. Furthermore, apoptosis of primary human ovarian carcinoma cells, which was induced by TNFalpha, FasL, and TRAIL, was also inhibited by holo-transferrin. The data suggest that Myc-activation, FasL, TNFalpha, and TRAIL disturbed cellular iron homeostasis, which triggered apoptosis of ovarian carcinoma cells and that transferrin iron ensured survival by re-establishing this homeostasis.",
keywords = "Apoptosis, Apoptosis Regulatory Proteins, Cell Survival, Fas Ligand Protein, Female, Humans, Membrane Glycoproteins, Ovarian Neoplasms, Proto-Oncogene Proteins c-myc, TNF-Related Apoptosis-Inducing Ligand, Transferrin, Tumor Necrosis Factor-alpha",
author = "Sandra Fassl and Christina Leisser and Simone Huettenbrenner and Susanne Maier and Georg Rosenberger and Stephan Strasser and Michael Grusch and Gerhard Fuhrmann and Katharina Leuhuber and Doris Polgar and Josefine Stani and Brigitte Tichy and Christine Nowotny and Georg Krupitza",
year = "2003",
month = nov,
day = "13",
doi = "10.1038/sj.onc.1207047",
language = "English",
volume = "22",
pages = "8343--55",
journal = "ONCOGENE",
issn = "0950-9232",
publisher = "NATURE PUBLISHING GROUP",
number = "51",

}

RIS

TY - JOUR

T1 - Transferrin ensures survival of ovarian carcinoma cells when apoptosis is induced by TNFalpha, FasL, TRAIL, or Myc

AU - Fassl, Sandra

AU - Leisser, Christina

AU - Huettenbrenner, Simone

AU - Maier, Susanne

AU - Rosenberger, Georg

AU - Strasser, Stephan

AU - Grusch, Michael

AU - Fuhrmann, Gerhard

AU - Leuhuber, Katharina

AU - Polgar, Doris

AU - Stani, Josefine

AU - Tichy, Brigitte

AU - Nowotny, Christine

AU - Krupitza, Georg

PY - 2003/11/13

Y1 - 2003/11/13

N2 - The activation of Myc induces apoptosis of human ovarian adenocarcinoma N.1 cells when serum factors are limited. However, the downstream mechanism that is triggered by Myc is unknown. Myc-activation and treatment with the proapoptotic ligands TNFalpha, FasL, and TRAIL induced H-ferritin expression under serum-deprived conditions. H-ferritin chelates intracellular iron and also intracellular iron sequestration by deferoxamine-induced apoptosis of N.1 cells. Supplementation of serum-free medium with holo-transferrin blocked apoptosis of N.1 cells that was induced by Myc-activation or by treatment with TNFalpha, FasL, and TRAIL, whereas apotransferrin did not prevent apoptosis. This suggests that intracellular iron depletion was a trigger for apoptosis and that transferrin-bound iron rescued N.1 cells. Furthermore, apoptosis of primary human ovarian carcinoma cells, which was induced by TNFalpha, FasL, and TRAIL, was also inhibited by holo-transferrin. The data suggest that Myc-activation, FasL, TNFalpha, and TRAIL disturbed cellular iron homeostasis, which triggered apoptosis of ovarian carcinoma cells and that transferrin iron ensured survival by re-establishing this homeostasis.

AB - The activation of Myc induces apoptosis of human ovarian adenocarcinoma N.1 cells when serum factors are limited. However, the downstream mechanism that is triggered by Myc is unknown. Myc-activation and treatment with the proapoptotic ligands TNFalpha, FasL, and TRAIL induced H-ferritin expression under serum-deprived conditions. H-ferritin chelates intracellular iron and also intracellular iron sequestration by deferoxamine-induced apoptosis of N.1 cells. Supplementation of serum-free medium with holo-transferrin blocked apoptosis of N.1 cells that was induced by Myc-activation or by treatment with TNFalpha, FasL, and TRAIL, whereas apotransferrin did not prevent apoptosis. This suggests that intracellular iron depletion was a trigger for apoptosis and that transferrin-bound iron rescued N.1 cells. Furthermore, apoptosis of primary human ovarian carcinoma cells, which was induced by TNFalpha, FasL, and TRAIL, was also inhibited by holo-transferrin. The data suggest that Myc-activation, FasL, TNFalpha, and TRAIL disturbed cellular iron homeostasis, which triggered apoptosis of ovarian carcinoma cells and that transferrin iron ensured survival by re-establishing this homeostasis.

KW - Apoptosis

KW - Apoptosis Regulatory Proteins

KW - Cell Survival

KW - Fas Ligand Protein

KW - Female

KW - Humans

KW - Membrane Glycoproteins

KW - Ovarian Neoplasms

KW - Proto-Oncogene Proteins c-myc

KW - TNF-Related Apoptosis-Inducing Ligand

KW - Transferrin

KW - Tumor Necrosis Factor-alpha

U2 - 10.1038/sj.onc.1207047

DO - 10.1038/sj.onc.1207047

M3 - SCORING: Journal article

C2 - 14614458

VL - 22

SP - 8343

EP - 8355

JO - ONCOGENE

JF - ONCOGENE

SN - 0950-9232

IS - 51

ER -