Tracheal replacement in rabbits with a new composite silicone-metallic prosthesis
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Tracheal replacement in rabbits with a new composite silicone-metallic prosthesis. / Dodge-Khatami, Ali; Niessen, Hans W M; Koole, Leo H; Klein, Marloes G; van Gulik, Thomas M; de Mol, Bas A J M.
in: ASIAN CARD THORAC AN, Jahrgang 11, Nr. 3, 09.2003, S. 245-249.Publikationen: SCORING: Beitrag in Fachzeitschrift/Zeitung › SCORING: Zeitschriftenaufsatz › Forschung › Begutachtung
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TY - JOUR
T1 - Tracheal replacement in rabbits with a new composite silicone-metallic prosthesis
AU - Dodge-Khatami, Ali
AU - Niessen, Hans W M
AU - Koole, Leo H
AU - Klein, Marloes G
AU - van Gulik, Thomas M
AU - de Mol, Bas A J M
PY - 2003/9
Y1 - 2003/9
N2 - A new composite silicone-metallic prosthesis was tested, studying the potential for respiratory epithelial covering over the biocompatible inner lining, in a rabbit survival model. Seven New Zealand White rabbits underwent near-total excision of their trachea and implantation of a sterile prosthesis. After 2 months, they were sacrificed and the prostheses were retrieved. Specimens were fixed and histologically examined for tissue reaction around the prosthesis, at the anastomotic lines, and particularly for the presence or absence of epithelialization of the inner lumen over the biocompatible surface. All rabbits survived the operation. At 2 months, the outer layer of the prosthesis was consistently covered with fibrosis and neutrophils. The inner layer showed necrotic cells and scant re-epithelialization over the biocompatible lining, up to 5 mm beyond the anastomosis, with no evidence of organized respiratory epithelium in the middle sections. The new prosthesis is a viable temporary solution for airway replacement in rabbits. Granulation tissue was not observed at the anastomosis, and re-epithelialization did occur, but failed to achieve full-length luminal covering. The potential for granulation tissue does not yet make this an ideal long-term solution. Improvements in prosthesis design or biocompatibility are required, and need to be re-evaluated before applicability for chronic use.
AB - A new composite silicone-metallic prosthesis was tested, studying the potential for respiratory epithelial covering over the biocompatible inner lining, in a rabbit survival model. Seven New Zealand White rabbits underwent near-total excision of their trachea and implantation of a sterile prosthesis. After 2 months, they were sacrificed and the prostheses were retrieved. Specimens were fixed and histologically examined for tissue reaction around the prosthesis, at the anastomotic lines, and particularly for the presence or absence of epithelialization of the inner lumen over the biocompatible surface. All rabbits survived the operation. At 2 months, the outer layer of the prosthesis was consistently covered with fibrosis and neutrophils. The inner layer showed necrotic cells and scant re-epithelialization over the biocompatible lining, up to 5 mm beyond the anastomosis, with no evidence of organized respiratory epithelium in the middle sections. The new prosthesis is a viable temporary solution for airway replacement in rabbits. Granulation tissue was not observed at the anastomosis, and re-epithelialization did occur, but failed to achieve full-length luminal covering. The potential for granulation tissue does not yet make this an ideal long-term solution. Improvements in prosthesis design or biocompatibility are required, and need to be re-evaluated before applicability for chronic use.
KW - Animals
KW - Biocompatible Materials/therapeutic use
KW - Metals/therapeutic use
KW - Prostheses and Implants
KW - Prosthesis Implantation/instrumentation
KW - Rabbits
KW - Silicones/therapeutic use
KW - Trachea/surgery
U2 - 10.1177/021849230301100314
DO - 10.1177/021849230301100314
M3 - SCORING: Journal article
C2 - 14514557
VL - 11
SP - 245
EP - 249
JO - ASIAN CARD THORAC AN
JF - ASIAN CARD THORAC AN
SN - 0218-4923
IS - 3
ER -