Toxicity screening of mouthwashes in the pollen tube growth test
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Toxicity screening of mouthwashes in the pollen tube growth test : safety assessment of recommended dilutions of twenty brands. / Kristen, Udo; Friedrich, Reinhard E.
in: IN VIVO, Jahrgang 18, Nr. 6, 2005, S. 803-7.Publikationen: SCORING: Beitrag in Fachzeitschrift/Zeitung › SCORING: Zeitschriftenaufsatz › Forschung › Begutachtung
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TY - JOUR
T1 - Toxicity screening of mouthwashes in the pollen tube growth test
T2 - safety assessment of recommended dilutions of twenty brands
AU - Kristen, Udo
AU - Friedrich, Reinhard E
PY - 2005
Y1 - 2005
N2 - The question of whether mouthwash dilutions, recommended by the producers, contribute to irritation of the oral mucosa was examined. Twenty frequently used mouthwash brands were examined by the pollen tube growth test, an alternative in vitro method for the irritation assessment of ingredients of cosmetic formulations. The test is based on the photometric quantification of pollen tube growth inhibition. This parameter is expressed by IC50 values which characterize the cytotoxic potency of a product. The IC50s clearly revealed that none of the tested mouthwashes should cause acute irritation if used at the recommended dilution. However, 4 to 5 of the mouthwashes could probably irritate the oral mucosa acutely, when used in the form of the original producer concentrations.
AB - The question of whether mouthwash dilutions, recommended by the producers, contribute to irritation of the oral mucosa was examined. Twenty frequently used mouthwash brands were examined by the pollen tube growth test, an alternative in vitro method for the irritation assessment of ingredients of cosmetic formulations. The test is based on the photometric quantification of pollen tube growth inhibition. This parameter is expressed by IC50 values which characterize the cytotoxic potency of a product. The IC50s clearly revealed that none of the tested mouthwashes should cause acute irritation if used at the recommended dilution. However, 4 to 5 of the mouthwashes could probably irritate the oral mucosa acutely, when used in the form of the original producer concentrations.
KW - Animal Testing Alternatives
KW - Dose-Response Relationship, Drug
KW - Flowers
KW - Mouthwashes
KW - Tobacco
KW - Toxicity Tests
M3 - SCORING: Journal article
C2 - 15646824
VL - 18
SP - 803
EP - 807
JO - IN VIVO
JF - IN VIVO
SN - 0258-851X
IS - 6
ER -