Three suicide attempts with moclobemide.
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Three suicide attempts with moclobemide. / Iwersen-Bergmann, Stefanie; Schmoldt, A.
in: J TOXICOL-CLIN TOXIC, Jahrgang 34, Nr. 2, 2, 1996, S. 223-225.Publikationen: SCORING: Beitrag in Fachzeitschrift/Zeitung › SCORING: Zeitschriftenaufsatz › Forschung › Begutachtung
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TY - JOUR
T1 - Three suicide attempts with moclobemide.
AU - Iwersen-Bergmann, Stefanie
AU - Schmoldt, A
PY - 1996
Y1 - 1996
N2 - OBJECTIVE: To report plasma moclobemide, course and outcome of two cases of overdose with moclobemide alone and one case of combined ingestion of moclobemide and clomipramide. METHODS: Moclobemide identification and quantification was achieved by gas chromatography-mass spectrometry after alkaline extraction. CASE REPORTS: In case 1, plasma moclobemide was 2.8 mg/L with 1.8 mg/L clomipramide; in case 2, 18 mg/L; in case 3 60.9 mg/L and 4.6 mg/L 12 hours later. None of the patients showed serious effects during 24 hours of observation. Plasma moclobemide at 10 to 30 times therapeutic was not associated with major toxic effects. Moclobemide seems to be considerably less toxic than tricyclic antidepressants.
AB - OBJECTIVE: To report plasma moclobemide, course and outcome of two cases of overdose with moclobemide alone and one case of combined ingestion of moclobemide and clomipramide. METHODS: Moclobemide identification and quantification was achieved by gas chromatography-mass spectrometry after alkaline extraction. CASE REPORTS: In case 1, plasma moclobemide was 2.8 mg/L with 1.8 mg/L clomipramide; in case 2, 18 mg/L; in case 3 60.9 mg/L and 4.6 mg/L 12 hours later. None of the patients showed serious effects during 24 hours of observation. Plasma moclobemide at 10 to 30 times therapeutic was not associated with major toxic effects. Moclobemide seems to be considerably less toxic than tricyclic antidepressants.
KW - Humans
KW - Female
KW - Middle Aged
KW - Drug Interactions
KW - Gas Chromatography-Mass Spectrometry
KW - Antidepressive Agents, Tricyclic/poisoning
KW - Benzamides/blood/poisoning
KW - Clomipramine/poisoning
KW - Drug Overdose
KW - Moclobemide
KW - Monoamine Oxidase Inhibitors/blood/poisoning
KW - Suicide, Attempted
KW - Humans
KW - Female
KW - Middle Aged
KW - Drug Interactions
KW - Gas Chromatography-Mass Spectrometry
KW - Antidepressive Agents, Tricyclic/poisoning
KW - Benzamides/blood/poisoning
KW - Clomipramine/poisoning
KW - Drug Overdose
KW - Moclobemide
KW - Monoamine Oxidase Inhibitors/blood/poisoning
KW - Suicide, Attempted
M3 - SCORING: Journal article
VL - 34
SP - 223
EP - 225
IS - 2
M1 - 2
ER -