The Rare Occurrence of the Translocation t(8;14) in Chronic Lymphatic Leukemia: Case Report and Review of the Literature
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The Rare Occurrence of the Translocation t(8;14) in Chronic Lymphatic Leukemia: Case Report and Review of the Literature. / Coym, Anja; Janjetovic, Snjezana; Bokemeyer, Carsten; Fiedler, Walter.
in: Ann Hematol Oncol, Jahrgang 2, Nr. 5, 03.06.2015, S. 1039.Publikationen: SCORING: Beitrag in Fachzeitschrift/Zeitung › SCORING: Zeitschriftenaufsatz › Forschung › Begutachtung
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T1 - The Rare Occurrence of the Translocation t(8;14) in Chronic Lymphatic Leukemia: Case Report and Review of the Literature
AU - Coym, Anja
AU - Janjetovic, Snjezana
AU - Bokemeyer, Carsten
AU - Fiedler, Walter
PY - 2015/6/3
Y1 - 2015/6/3
N2 - Genomic aberrations in Chronic Lymphatic Leukemia (CLL) are importantprognostic factors of disease progression and survival and contribute to thetreatment decisions and follow-up. The most common chromosomal aberrationsdetected in CLL are deletions of 13q14, 11q22, 17p13 and trisomy 12. Deletions17p13.1 and 11q22.3 are strong predictors of poor survival. We report on arare case of CLL exhibiting the MYC translocation t(8,14)(q24;q32), which is aconsistent cytogenetic finding of Burkitt lymphoma. This translocation in CLLmostly appears with other chromosomal abnormalities and is associated withmore aggressive disease behavior. After review of the literature, the outcomeof CLL patients with MYC translocation is discussed, where prognosis is oftenpoor.
AB - Genomic aberrations in Chronic Lymphatic Leukemia (CLL) are importantprognostic factors of disease progression and survival and contribute to thetreatment decisions and follow-up. The most common chromosomal aberrationsdetected in CLL are deletions of 13q14, 11q22, 17p13 and trisomy 12. Deletions17p13.1 and 11q22.3 are strong predictors of poor survival. We report on arare case of CLL exhibiting the MYC translocation t(8,14)(q24;q32), which is aconsistent cytogenetic finding of Burkitt lymphoma. This translocation in CLLmostly appears with other chromosomal abnormalities and is associated withmore aggressive disease behavior. After review of the literature, the outcomeof CLL patients with MYC translocation is discussed, where prognosis is oftenpoor.
M3 - SCORING: Journal article
VL - 2
SP - 1039
JO - Ann Hematol Oncol
JF - Ann Hematol Oncol
SN - 2375-7965
IS - 5
ER -