The New Old CD8+ T Cells in the Immune Paradox of Pregnancy
Standard
The New Old CD8+ T Cells in the Immune Paradox of Pregnancy. / Hardardottir, Lilja; Bazzano, Maria Victoria; Glau, Laura; Gattinoni, Luca; Köninger, Angela; Tolosa, Eva; Solano, Maria Emilia.
in: FRONT IMMUNOL, Jahrgang 12, 765730, 2021.Publikationen: SCORING: Beitrag in Fachzeitschrift/Zeitung › SCORING: Review › Forschung
Harvard
APA
Vancouver
Bibtex
}
RIS
TY - JOUR
T1 - The New Old CD8+ T Cells in the Immune Paradox of Pregnancy
AU - Hardardottir, Lilja
AU - Bazzano, Maria Victoria
AU - Glau, Laura
AU - Gattinoni, Luca
AU - Köninger, Angela
AU - Tolosa, Eva
AU - Solano, Maria Emilia
N1 - Copyright © 2021 Hardardottir, Bazzano, Glau, Gattinoni, Köninger, Tolosa and Solano.
PY - 2021
Y1 - 2021
N2 - CD8+ T cells are the most frequent T cell population in the immune cell compartment at the feto-maternal interface. Due to their cytotoxic potential, the presence of CD8+ T cells in the immune privileged pregnant uterus has raised considerable interest. Here, we review our current understanding of CD8+ T cell biology in the uterus of pregnant women and discuss this knowledge in relation to a recently published immune cell Atlas of human decidua. We describe how the expansion of CD8+ T cells with an effector memory phenotype often presenting markers of exhaustion is critical for a successful pregnancy, and host defense towards pathogens. Moreover, we review new evidence on the presence of long-lasting immunological memory to former pregnancies and discuss its impact on prospective pregnancy outcomes. The formation of fetal-specific memory CD8+ T cell subests in the uterus, in particular of tissue resident, and stem cell memory cells requires further investigation, but promises interesting results to come. Advancing the knowledge of CD8+ T cell biology in the pregnant uterus will be pivotal for understanding not only tissue-specific immune tolerance but also the etiology of complications during pregnancy, thus enabling preventive or therapeutic interventions in the future.
AB - CD8+ T cells are the most frequent T cell population in the immune cell compartment at the feto-maternal interface. Due to their cytotoxic potential, the presence of CD8+ T cells in the immune privileged pregnant uterus has raised considerable interest. Here, we review our current understanding of CD8+ T cell biology in the uterus of pregnant women and discuss this knowledge in relation to a recently published immune cell Atlas of human decidua. We describe how the expansion of CD8+ T cells with an effector memory phenotype often presenting markers of exhaustion is critical for a successful pregnancy, and host defense towards pathogens. Moreover, we review new evidence on the presence of long-lasting immunological memory to former pregnancies and discuss its impact on prospective pregnancy outcomes. The formation of fetal-specific memory CD8+ T cell subests in the uterus, in particular of tissue resident, and stem cell memory cells requires further investigation, but promises interesting results to come. Advancing the knowledge of CD8+ T cell biology in the pregnant uterus will be pivotal for understanding not only tissue-specific immune tolerance but also the etiology of complications during pregnancy, thus enabling preventive or therapeutic interventions in the future.
U2 - 10.3389/fimmu.2021.765730
DO - 10.3389/fimmu.2021.765730
M3 - SCORING: Review article
C2 - 34868016
VL - 12
JO - FRONT IMMUNOL
JF - FRONT IMMUNOL
SN - 1664-3224
M1 - 765730
ER -