The natural and the inducible interleukin (IL)-17-producing γδ T cells
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The natural and the inducible interleukin (IL)-17-producing γδ T cells. / Chien, Yueh-hsiu; Zeng, Xun; Prinz, Immo.
in: TRENDS IMMUNOL, Jahrgang 34, Nr. 4, 04.2013, S. 151-4.Publikationen: SCORING: Beitrag in Fachzeitschrift/Zeitung › SCORING: Review › Forschung
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TY - JOUR
T1 - The natural and the inducible interleukin (IL)-17-producing γδ T cells
AU - Chien, Yueh-hsiu
AU - Zeng, Xun
AU - Prinz, Immo
N1 - Copyright © 2012 Elsevier Ltd. All rights reserved.
PY - 2013/4
Y1 - 2013/4
N2 - γδ T cells are the major initial interleukin (IL)-17 producers in acute infections. Recent studies have indicated that some γδ T cells have IL-17-producing capabilities without explicit induction of an immune response. They are preferentially localized in barrier tissues and are likely to originate from fetal γδ thymocytes. In addition, γδ T cells present in the secondary lymphoid organs will mature and differentiate to produce IL-17 after antigen encounter in an immune response. Based on these studies, we propose that there are two different sets of IL-17-producing γδ T cells (Tγδ17) referred to as the 'natural' and the 'inducible' Tγδ17 cells. This review focuses on recent publications leading to the delineation of these two types of cells and their implied roles in host immune defense.
AB - γδ T cells are the major initial interleukin (IL)-17 producers in acute infections. Recent studies have indicated that some γδ T cells have IL-17-producing capabilities without explicit induction of an immune response. They are preferentially localized in barrier tissues and are likely to originate from fetal γδ thymocytes. In addition, γδ T cells present in the secondary lymphoid organs will mature and differentiate to produce IL-17 after antigen encounter in an immune response. Based on these studies, we propose that there are two different sets of IL-17-producing γδ T cells (Tγδ17) referred to as the 'natural' and the 'inducible' Tγδ17 cells. This review focuses on recent publications leading to the delineation of these two types of cells and their implied roles in host immune defense.
KW - Acute Disease
KW - Animals
KW - Cell Differentiation/immunology
KW - Humans
KW - Immunity, Cellular
KW - Infections/immunology
KW - Interleukin-17/immunology
KW - Receptors, Antigen, T-Cell, gamma-delta/immunology
KW - T-Lymphocyte Subsets/immunology
KW - Th17 Cells/immunology
U2 - 10.1016/j.it.2012.11.004
DO - 10.1016/j.it.2012.11.004
M3 - SCORING: Review article
C2 - 23266231
VL - 34
SP - 151
EP - 154
JO - TRENDS IMMUNOL
JF - TRENDS IMMUNOL
SN - 1471-4906
IS - 4
ER -