PortalPublikationenThe LPS receptor, CD14, in experimental autoimmune encephalo...

The LPS receptor, CD14, in experimental autoimmune encephalomyelitis and multiple sclerosis.

Standard

The LPS receptor, CD14, in experimental autoimmune encephalomyelitis and multiple sclerosis. / Walter, Silke; Doering, Axinia; Letiembre, Maryse; Liu, Yang; Hao, Wenlin; Diem, Ricarda; Bernreuther, Christian; Glatzel, Markus; Engelhardt, Britta; Fassbender, Klaus.

in: CELL PHYSIOL BIOCHEM, Jahrgang 17, Nr. 3-4, 3-4, 2006, S. 167-172.

Publikationen: SCORING: Beitrag in Fachzeitschrift/Zeitung › SCORING: Zeitschriftenaufsatz › Forschung › Begutachtung

Harvard

Walter, S, Doering, A, Letiembre, M, Liu, Y, Hao, W, Diem, R, Bernreuther, C, Glatzel, M, Engelhardt, B & Fassbender, K 2006, 'The LPS receptor, CD14, in experimental autoimmune encephalomyelitis and multiple sclerosis.', CELL PHYSIOL BIOCHEM, Jg. 17, Nr. 3-4, 3-4, S. 167-172. https://doi.org/10.1159/000092078

APA

Walter, S., Doering, A., Letiembre, M., Liu, Y., Hao, W., Diem, R., Bernreuther, C., Glatzel, M., Engelhardt, B., & Fassbender, K. (2006). The LPS receptor, CD14, in experimental autoimmune encephalomyelitis and multiple sclerosis. CELL PHYSIOL BIOCHEM, 17(3-4), 167-172. [3-4]. https://doi.org/10.1159/000092078

Vancouver

Walter S, Doering A, Letiembre M, Liu Y, Hao W, Diem R et al. The LPS receptor, CD14, in experimental autoimmune encephalomyelitis and multiple sclerosis. CELL PHYSIOL BIOCHEM. 2006;17(3-4):167-172. 3-4. https://doi.org/10.1159/000092078

Bibtex

@article{8c468f85e5df492c833e93666f1609d9,
title = "The LPS receptor, CD14, in experimental autoimmune encephalomyelitis and multiple sclerosis.",
abstract = "Innate immune receptors are crucial for defense against microorganisms. Recently, a cross-talk between innate and adaptive immunity has been considered. Here, we provide first evidence for a role of the key innate immune receptor, LPS receptor (CD14) in pathophysiology of experimental autoimmune encephalomyelitis, the animal model of multiple sclerosis. Indicating a functional importance in vivo, we show that CD14 deficiency increased clinical symptoms in active experimental autoimmune encephalomyelitis. Consistent with these observations, CD14 deficient mice exhibited a markedly enhanced infiltration of monocytes and neutrophils in brain and spinal cord. Moreover, we observed an increased immunoreactivity of CD14 in biopsy and post mortem brain tissues of multiple sclerosis patients compared to age-matched controls. Thus, the key innate immune receptor, CD14, may be of pathophysiological relevance in experimental autoimmune encephalomyelitis and multiple sclerosis.",
author = "Silke Walter and Axinia Doering and Maryse Letiembre and Yang Liu and Wenlin Hao and Ricarda Diem and Christian Bernreuther and Markus Glatzel and Britta Engelhardt and Klaus Fassbender",
year = "2006",
doi = "10.1159/000092078",
language = "Deutsch",
volume = "17",
pages = "167--172",
journal = "CELL PHYSIOL BIOCHEM",
issn = "1015-8987",
publisher = "S. Karger AG",
number = "3-4",

}

RIS

TY - JOUR

T1 - The LPS receptor, CD14, in experimental autoimmune encephalomyelitis and multiple sclerosis.

AU - Walter, Silke

AU - Doering, Axinia

AU - Letiembre, Maryse

AU - Liu, Yang

AU - Hao, Wenlin

AU - Diem, Ricarda

AU - Bernreuther, Christian

AU - Glatzel, Markus

AU - Engelhardt, Britta

AU - Fassbender, Klaus

PY - 2006

Y1 - 2006

N2 - Innate immune receptors are crucial for defense against microorganisms. Recently, a cross-talk between innate and adaptive immunity has been considered. Here, we provide first evidence for a role of the key innate immune receptor, LPS receptor (CD14) in pathophysiology of experimental autoimmune encephalomyelitis, the animal model of multiple sclerosis. Indicating a functional importance in vivo, we show that CD14 deficiency increased clinical symptoms in active experimental autoimmune encephalomyelitis. Consistent with these observations, CD14 deficient mice exhibited a markedly enhanced infiltration of monocytes and neutrophils in brain and spinal cord. Moreover, we observed an increased immunoreactivity of CD14 in biopsy and post mortem brain tissues of multiple sclerosis patients compared to age-matched controls. Thus, the key innate immune receptor, CD14, may be of pathophysiological relevance in experimental autoimmune encephalomyelitis and multiple sclerosis.

AB - Innate immune receptors are crucial for defense against microorganisms. Recently, a cross-talk between innate and adaptive immunity has been considered. Here, we provide first evidence for a role of the key innate immune receptor, LPS receptor (CD14) in pathophysiology of experimental autoimmune encephalomyelitis, the animal model of multiple sclerosis. Indicating a functional importance in vivo, we show that CD14 deficiency increased clinical symptoms in active experimental autoimmune encephalomyelitis. Consistent with these observations, CD14 deficient mice exhibited a markedly enhanced infiltration of monocytes and neutrophils in brain and spinal cord. Moreover, we observed an increased immunoreactivity of CD14 in biopsy and post mortem brain tissues of multiple sclerosis patients compared to age-matched controls. Thus, the key innate immune receptor, CD14, may be of pathophysiological relevance in experimental autoimmune encephalomyelitis and multiple sclerosis.

U2 - 10.1159/000092078

DO - 10.1159/000092078

M3 - SCORING: Zeitschriftenaufsatz

VL - 17

SP - 167

EP - 172

JO - CELL PHYSIOL BIOCHEM

JF - CELL PHYSIOL BIOCHEM

SN - 1015-8987

IS - 3-4

M1 - 3-4

ER -