The ins-and-outs of podocyte lipid metabolism
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The ins-and-outs of podocyte lipid metabolism. / Meyer-Schwesinger, Catherine.
in: KIDNEY INT, Jahrgang 98, Nr. 5, 11.2020, S. 1087-1090.Publikationen: SCORING: Beitrag in Fachzeitschrift/Zeitung › Andere (Vorworte u.ä.) › Forschung
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TY - JOUR
T1 - The ins-and-outs of podocyte lipid metabolism
AU - Meyer-Schwesinger, Catherine
N1 - Editorial Material
PY - 2020/11
Y1 - 2020/11
N2 - Obesity and hyperlipidemia are the most prevalent independent risk factors of ESRD, suggesting that lipid accumulation is detrimental to renal function. The origin of lipid accumulation (a common feature in podocyte injury) and its pathophysiological relevance are unknown. This commentary discusses the finding by Liu et al. that deficiency of the endoplasmic reticulum enzyme SOAT1, which metabolizes cholesterol to cholesterol esters, attenuates renal/podocyte injury in murine models of diabetes and Alport's syndrome.
AB - Obesity and hyperlipidemia are the most prevalent independent risk factors of ESRD, suggesting that lipid accumulation is detrimental to renal function. The origin of lipid accumulation (a common feature in podocyte injury) and its pathophysiological relevance are unknown. This commentary discusses the finding by Liu et al. that deficiency of the endoplasmic reticulum enzyme SOAT1, which metabolizes cholesterol to cholesterol esters, attenuates renal/podocyte injury in murine models of diabetes and Alport's syndrome.
KW - Animals
KW - Diabetes Mellitus/metabolism
KW - Kidney
KW - Lipid Metabolism
KW - Mice
KW - Nephritis, Hereditary/metabolism
KW - Podocytes/metabolism
U2 - 10.1016/j.kint.2020.07.008
DO - 10.1016/j.kint.2020.07.008
M3 - Other (editorial matter etc.)
C2 - 33126971
VL - 98
SP - 1087
EP - 1090
JO - KIDNEY INT
JF - KIDNEY INT
SN - 0085-2538
IS - 5
ER -