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The influence of dietary lectins on the cell proliferation of human breast cancer cell lines in vitro

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The influence of dietary lectins on the cell proliferation of human breast cancer cell lines in vitro. / Valentiner, Ursula; Fabian, Stefanie; Schumacher, Udo; Leathem, Anthony J.

in: ANTICANCER RES, Jahrgang 23, Nr. 2B, 25.06.2003, S. 1197-206.

Publikationen: SCORING: Beitrag in Fachzeitschrift/Zeitung › SCORING: Zeitschriftenaufsatz › Forschung › Begutachtung

Harvard

Valentiner, U, Fabian, S, Schumacher, U & Leathem, AJ 2003, 'The influence of dietary lectins on the cell proliferation of human breast cancer cell lines in vitro', ANTICANCER RES, Jg. 23, Nr. 2B, S. 1197-206.

APA

Valentiner, U., Fabian, S., Schumacher, U., & Leathem, A. J. (2003). The influence of dietary lectins on the cell proliferation of human breast cancer cell lines in vitro. ANTICANCER RES, 23(2B), 1197-206.

Vancouver

Valentiner U, Fabian S, Schumacher U, Leathem AJ. The influence of dietary lectins on the cell proliferation of human breast cancer cell lines in vitro. ANTICANCER RES. 2003 Jun 25;23(2B):1197-206.

Bibtex

@article{75c896d750914e3fa77d4b28b1b6d537,
title = "The influence of dietary lectins on the cell proliferation of human breast cancer cell lines in vitro",
abstract = "BACKGROUND: Lectins, carbohydrate proteins, bind non-covalently to glycoconjugate of normal and malignant cells. If used in cell culture, they can influence cellular proliferation. In this study the in vitro effects of six dietary lectins on the cell proliferation of human breast cancer cell lines were investigated.MATERIALS AND METHODS: Cell proliferation was assessed by a colorimetric XTT-based assay kit. Lectin binding was characterized by lectin histochemistry.RESULTS: WGA considerably influenced the cell growth of all tested cell lines (MCF-7, T 47D, HBL 100, BT 20), whereas the effects of PHA-L, SBA and HPA were smaller, began at higher concentrations and were restricted to three cell lines (MCF-7, T 47D and HBL 100 for PHA-L; MCF-7, T 47D and BT 20 for SBA, respectively) and to one cell line (HBL 100 for HPA). STA and PNA had no effect at all.CONCLUSION: The present data suggested that some dietary lectins can inhibit cell growth of human breast cancer cells in vitro. These findings would argue for a protective effect of these plant lectins for breast cancer.",
keywords = "Adenocarcinoma, Breast, Breast Neoplasms, Carbohydrate Metabolism, Cell Division, Cells, Cultured, Diet, Epithelial Cells, Female, Humans, Lectins, Peanut Agglutinin, Phytohemagglutinins, Plant Lectins, Soybean Proteins, Tissue Fixation, Tumor Cells, Cultured, Wheat Germ Agglutinins",
author = "Ursula Valentiner and Stefanie Fabian and Udo Schumacher and Leathem, {Anthony J}",
year = "2003",
month = jun,
day = "25",
language = "English",
volume = "23",
pages = "1197--206",
journal = "ANTICANCER RES",
issn = "0250-7005",
publisher = "International Institute of Anticancer Research",
number = "2B",

}

RIS

TY - JOUR

T1 - The influence of dietary lectins on the cell proliferation of human breast cancer cell lines in vitro

AU - Valentiner, Ursula

AU - Fabian, Stefanie

AU - Schumacher, Udo

AU - Leathem, Anthony J

PY - 2003/6/25

Y1 - 2003/6/25

N2 - BACKGROUND: Lectins, carbohydrate proteins, bind non-covalently to glycoconjugate of normal and malignant cells. If used in cell culture, they can influence cellular proliferation. In this study the in vitro effects of six dietary lectins on the cell proliferation of human breast cancer cell lines were investigated.MATERIALS AND METHODS: Cell proliferation was assessed by a colorimetric XTT-based assay kit. Lectin binding was characterized by lectin histochemistry.RESULTS: WGA considerably influenced the cell growth of all tested cell lines (MCF-7, T 47D, HBL 100, BT 20), whereas the effects of PHA-L, SBA and HPA were smaller, began at higher concentrations and were restricted to three cell lines (MCF-7, T 47D and HBL 100 for PHA-L; MCF-7, T 47D and BT 20 for SBA, respectively) and to one cell line (HBL 100 for HPA). STA and PNA had no effect at all.CONCLUSION: The present data suggested that some dietary lectins can inhibit cell growth of human breast cancer cells in vitro. These findings would argue for a protective effect of these plant lectins for breast cancer.

AB - BACKGROUND: Lectins, carbohydrate proteins, bind non-covalently to glycoconjugate of normal and malignant cells. If used in cell culture, they can influence cellular proliferation. In this study the in vitro effects of six dietary lectins on the cell proliferation of human breast cancer cell lines were investigated.MATERIALS AND METHODS: Cell proliferation was assessed by a colorimetric XTT-based assay kit. Lectin binding was characterized by lectin histochemistry.RESULTS: WGA considerably influenced the cell growth of all tested cell lines (MCF-7, T 47D, HBL 100, BT 20), whereas the effects of PHA-L, SBA and HPA were smaller, began at higher concentrations and were restricted to three cell lines (MCF-7, T 47D and HBL 100 for PHA-L; MCF-7, T 47D and BT 20 for SBA, respectively) and to one cell line (HBL 100 for HPA). STA and PNA had no effect at all.CONCLUSION: The present data suggested that some dietary lectins can inhibit cell growth of human breast cancer cells in vitro. These findings would argue for a protective effect of these plant lectins for breast cancer.

KW - Adenocarcinoma

KW - Breast

KW - Breast Neoplasms

KW - Carbohydrate Metabolism

KW - Cell Division

KW - Cells, Cultured

KW - Diet

KW - Epithelial Cells

KW - Female

KW - Humans

KW - Lectins

KW - Peanut Agglutinin

KW - Phytohemagglutinins

KW - Plant Lectins

KW - Soybean Proteins

KW - Tissue Fixation

KW - Tumor Cells, Cultured

KW - Wheat Germ Agglutinins

M3 - SCORING: Journal article

C2 - 12820371

VL - 23

SP - 1197

EP - 1206

JO - ANTICANCER RES

JF - ANTICANCER RES

SN - 0250-7005

IS - 2B

ER -