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The early expression of VAChT and VIP in mouse sympathetic ganglia is not induced by cytokines acting through LIFRbeta or CNTFRalpha

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The early expression of VAChT and VIP in mouse sympathetic ganglia is not induced by cytokines acting through LIFRbeta or CNTFRalpha. / Stanke, M; Geissen, M; Götz, R; Ernsberger, U; Rohrer, H.

in: MECH DEVELOP, Jahrgang 91, Nr. 1-2, 01.03.2000, S. 91-96.

Publikationen: SCORING: Beitrag in Fachzeitschrift/Zeitung › SCORING: Zeitschriftenaufsatz › Forschung › Begutachtung

Harvard

Stanke, M, Geissen, M, Götz, R, Ernsberger, U & Rohrer, H 2000, 'The early expression of VAChT and VIP in mouse sympathetic ganglia is not induced by cytokines acting through LIFRbeta or CNTFRalpha', MECH DEVELOP, Jg. 91, Nr. 1-2, S. 91-96. https://doi.org/10.1016/s0925-4773(99)00275-0

APA

Stanke, M., Geissen, M., Götz, R., Ernsberger, U., & Rohrer, H. (2000). The early expression of VAChT and VIP in mouse sympathetic ganglia is not induced by cytokines acting through LIFRbeta or CNTFRalpha. MECH DEVELOP, 91(1-2), 91-96. https://doi.org/10.1016/s0925-4773(99)00275-0

Vancouver

Stanke M, Geissen M, Götz R, Ernsberger U, Rohrer H. The early expression of VAChT and VIP in mouse sympathetic ganglia is not induced by cytokines acting through LIFRbeta or CNTFRalpha. MECH DEVELOP. 2000 Mär 1;91(1-2):91-96. https://doi.org/10.1016/s0925-4773(99)00275-0

Bibtex

@article{22a5fc87e87e4251bc3aac9d10149241,
title = "The early expression of VAChT and VIP in mouse sympathetic ganglia is not induced by cytokines acting through LIFRbeta or CNTFRalpha",
abstract = "Sympathetic ganglia consist of noradrenergic and cholinergic neurons. The cholinergic marker protein vesicular acetylcholine transporter (VAChT) and the neuropeptide vasoactive intestinal peptide (VIP), co-expressed in mature cholinergic sympathetic neurons, are first detectable during embryonic development of rat sympathetic ganglia. However, the subpopulation of cholinergic sympathetic neurons which innervates sweat glands in mammalian footpads starts to express VAChT and VIP during the first postnatal weeks, under the influence of sweat gland-derived signals. In vitro evidence suggests that the sweat gland-derived cholinergic differentiation factor belongs to a group of neuropoietic cytokines, including LIF, CNTF and CT-1, that act through a LIFRbeta-containing cytokine receptor. To investigate whether the embryonic expression of cholinergic properties is elicited by a related cytokine, the expression of VAChT and VIP was analyzed in stellate ganglia of mice deficient for the cytokine receptor subunits LIFRbeta or CNTFRalpha. The density of VAChT- and VIP-immunoreactive cells in stellate ganglia of new-born animals was not different in LIFRbeta(-/-) and CNTFRalpha(-/-) ganglia as compared to ganglia from wild-type mice. These results demonstrate that the early, embryonic expression of VAChT and VIP is not induced by cytokines acting through LIFRbeta- or CNTFRalpha-containing receptors.",
keywords = "Animals, Carrier Proteins/metabolism, Ciliary Neurotrophic Factor/metabolism, Growth Inhibitors/metabolism, Interleukin-6, Leukemia Inhibitory Factor, Leukemia Inhibitory Factor Receptor alpha Subunit, Lymphokines/metabolism, Membrane Transport Proteins, Mice, Rabbits, Rats, Receptor, Ciliary Neurotrophic Factor/metabolism, Receptors, Cytokine/metabolism, Receptors, OSM-LIF, Stellate Ganglion/metabolism, Vasoactive Intestinal Peptide/metabolism, Vesicular Acetylcholine Transport Proteins, Vesicular Transport Proteins",
author = "M Stanke and M Geissen and R G{\"o}tz and U Ernsberger and H Rohrer",
year = "2000",
month = mar,
day = "1",
doi = "10.1016/s0925-4773(99)00275-0",
language = "English",
volume = "91",
pages = "91--96",
journal = "MECH DEVELOP",
issn = "0925-4773",
publisher = "Elsevier Ireland Ltd",
number = "1-2",

}

RIS

TY - JOUR

T1 - The early expression of VAChT and VIP in mouse sympathetic ganglia is not induced by cytokines acting through LIFRbeta or CNTFRalpha

AU - Stanke, M

AU - Geissen, M

AU - Götz, R

AU - Ernsberger, U

AU - Rohrer, H

PY - 2000/3/1

Y1 - 2000/3/1

N2 - Sympathetic ganglia consist of noradrenergic and cholinergic neurons. The cholinergic marker protein vesicular acetylcholine transporter (VAChT) and the neuropeptide vasoactive intestinal peptide (VIP), co-expressed in mature cholinergic sympathetic neurons, are first detectable during embryonic development of rat sympathetic ganglia. However, the subpopulation of cholinergic sympathetic neurons which innervates sweat glands in mammalian footpads starts to express VAChT and VIP during the first postnatal weeks, under the influence of sweat gland-derived signals. In vitro evidence suggests that the sweat gland-derived cholinergic differentiation factor belongs to a group of neuropoietic cytokines, including LIF, CNTF and CT-1, that act through a LIFRbeta-containing cytokine receptor. To investigate whether the embryonic expression of cholinergic properties is elicited by a related cytokine, the expression of VAChT and VIP was analyzed in stellate ganglia of mice deficient for the cytokine receptor subunits LIFRbeta or CNTFRalpha. The density of VAChT- and VIP-immunoreactive cells in stellate ganglia of new-born animals was not different in LIFRbeta(-/-) and CNTFRalpha(-/-) ganglia as compared to ganglia from wild-type mice. These results demonstrate that the early, embryonic expression of VAChT and VIP is not induced by cytokines acting through LIFRbeta- or CNTFRalpha-containing receptors.

AB - Sympathetic ganglia consist of noradrenergic and cholinergic neurons. The cholinergic marker protein vesicular acetylcholine transporter (VAChT) and the neuropeptide vasoactive intestinal peptide (VIP), co-expressed in mature cholinergic sympathetic neurons, are first detectable during embryonic development of rat sympathetic ganglia. However, the subpopulation of cholinergic sympathetic neurons which innervates sweat glands in mammalian footpads starts to express VAChT and VIP during the first postnatal weeks, under the influence of sweat gland-derived signals. In vitro evidence suggests that the sweat gland-derived cholinergic differentiation factor belongs to a group of neuropoietic cytokines, including LIF, CNTF and CT-1, that act through a LIFRbeta-containing cytokine receptor. To investigate whether the embryonic expression of cholinergic properties is elicited by a related cytokine, the expression of VAChT and VIP was analyzed in stellate ganglia of mice deficient for the cytokine receptor subunits LIFRbeta or CNTFRalpha. The density of VAChT- and VIP-immunoreactive cells in stellate ganglia of new-born animals was not different in LIFRbeta(-/-) and CNTFRalpha(-/-) ganglia as compared to ganglia from wild-type mice. These results demonstrate that the early, embryonic expression of VAChT and VIP is not induced by cytokines acting through LIFRbeta- or CNTFRalpha-containing receptors.

KW - Animals

KW - Carrier Proteins/metabolism

KW - Ciliary Neurotrophic Factor/metabolism

KW - Growth Inhibitors/metabolism

KW - Interleukin-6

KW - Leukemia Inhibitory Factor

KW - Leukemia Inhibitory Factor Receptor alpha Subunit

KW - Lymphokines/metabolism

KW - Membrane Transport Proteins

KW - Mice

KW - Rabbits

KW - Rats

KW - Receptor, Ciliary Neurotrophic Factor/metabolism

KW - Receptors, Cytokine/metabolism

KW - Receptors, OSM-LIF

KW - Stellate Ganglion/metabolism

KW - Vasoactive Intestinal Peptide/metabolism

KW - Vesicular Acetylcholine Transport Proteins

KW - Vesicular Transport Proteins

U2 - 10.1016/s0925-4773(99)00275-0

DO - 10.1016/s0925-4773(99)00275-0

M3 - SCORING: Journal article

C2 - 10704834

VL - 91

SP - 91

EP - 96

JO - MECH DEVELOP

JF - MECH DEVELOP

SN - 0925-4773

IS - 1-2

ER -