PortalPublikationenThe cytoplasmic tail of the T cell receptor zeta chain is re...

The cytoplasmic tail of the T cell receptor zeta chain is required for signaling via CD26

Standard

The cytoplasmic tail of the T cell receptor zeta chain is required for signaling via CD26. / Mittrücker, H W; Steeg, C; Malissen, B; Fleischer, B.

in: EUR J IMMUNOL, Jahrgang 25, Nr. 1, 01.01.1995, S. 295-7.

Publikationen: SCORING: Beitrag in Fachzeitschrift/Zeitung › SCORING: Zeitschriftenaufsatz › Forschung › Begutachtung

Harvard

Mittrücker, HW, Steeg, C, Malissen, B & Fleischer, B 1995, 'The cytoplasmic tail of the T cell receptor zeta chain is required for signaling via CD26', EUR J IMMUNOL, Jg. 25, Nr. 1, S. 295-7. https://doi.org/10.1002/eji.1830250149

APA

Mittrücker, H. W., Steeg, C., Malissen, B., & Fleischer, B. (1995). The cytoplasmic tail of the T cell receptor zeta chain is required for signaling via CD26. EUR J IMMUNOL, 25(1), 295-7. https://doi.org/10.1002/eji.1830250149

Vancouver

Mittrücker HW, Steeg C, Malissen B, Fleischer B. The cytoplasmic tail of the T cell receptor zeta chain is required for signaling via CD26. EUR J IMMUNOL. 1995 Jan 1;25(1):295-7. https://doi.org/10.1002/eji.1830250149

Bibtex

@article{1c55205935e44e36aebaf05f6bdb0e9e,
title = "The cytoplasmic tail of the T cell receptor zeta chain is required for signaling via CD26",
abstract = "The protease dipeptidylpeptidase IV (CD26) provides an alternative activation pathway for T lymphocytes and is involved in several aspects of T cell function. Activation via CD26 requires the expression of the T cell receptor (TcR)/CD3 complex. Here we have investigated the role of the TcR zeta chain for T cell activation via CD26. T cell hybridomas expressing TcR with various deletions in the CD3 zeta chain were transfected with a CD26 cDNA and the response of the transfected cells to anti-CD26 monoclonal antibodies was tested. Our data show that the zeta chain is essential and that at least one YXXL motif in the cytoplasmic tail of the zeta chain is required for CD26-mediated signaling. Other TcR components do not replace the zeta chain.",
keywords = "Animals, Dipeptidyl Peptidase 4, Flow Cytometry, Lymphocyte Activation, Membrane Proteins, Mice, Mice, Inbred AKR, Polymerase Chain Reaction, Receptors, Antigen, T-Cell, Signal Transduction, Structure-Activity Relationship, T-Lymphocytes, Transfection, Tumor Cells, Cultured",
author = "Mittr{\"u}cker, {H W} and C Steeg and B Malissen and B Fleischer",
year = "1995",
month = jan,
day = "1",
doi = "10.1002/eji.1830250149",
language = "English",
volume = "25",
pages = "295--7",
journal = "EUR J IMMUNOL",
issn = "0014-2980",
publisher = "Wiley-VCH Verlag GmbH",
number = "1",

}

RIS

TY - JOUR

T1 - The cytoplasmic tail of the T cell receptor zeta chain is required for signaling via CD26

AU - Mittrücker, H W

AU - Steeg, C

AU - Malissen, B

AU - Fleischer, B

PY - 1995/1/1

Y1 - 1995/1/1

N2 - The protease dipeptidylpeptidase IV (CD26) provides an alternative activation pathway for T lymphocytes and is involved in several aspects of T cell function. Activation via CD26 requires the expression of the T cell receptor (TcR)/CD3 complex. Here we have investigated the role of the TcR zeta chain for T cell activation via CD26. T cell hybridomas expressing TcR with various deletions in the CD3 zeta chain were transfected with a CD26 cDNA and the response of the transfected cells to anti-CD26 monoclonal antibodies was tested. Our data show that the zeta chain is essential and that at least one YXXL motif in the cytoplasmic tail of the zeta chain is required for CD26-mediated signaling. Other TcR components do not replace the zeta chain.

AB - The protease dipeptidylpeptidase IV (CD26) provides an alternative activation pathway for T lymphocytes and is involved in several aspects of T cell function. Activation via CD26 requires the expression of the T cell receptor (TcR)/CD3 complex. Here we have investigated the role of the TcR zeta chain for T cell activation via CD26. T cell hybridomas expressing TcR with various deletions in the CD3 zeta chain were transfected with a CD26 cDNA and the response of the transfected cells to anti-CD26 monoclonal antibodies was tested. Our data show that the zeta chain is essential and that at least one YXXL motif in the cytoplasmic tail of the zeta chain is required for CD26-mediated signaling. Other TcR components do not replace the zeta chain.

KW - Animals

KW - Dipeptidyl Peptidase 4

KW - Flow Cytometry

KW - Lymphocyte Activation

KW - Membrane Proteins

KW - Mice

KW - Mice, Inbred AKR

KW - Polymerase Chain Reaction

KW - Receptors, Antigen, T-Cell

KW - Signal Transduction

KW - Structure-Activity Relationship

KW - T-Lymphocytes

KW - Transfection

KW - Tumor Cells, Cultured

U2 - 10.1002/eji.1830250149

DO - 10.1002/eji.1830250149

M3 - SCORING: Journal article

C2 - 7843246

VL - 25

SP - 295

EP - 297

JO - EUR J IMMUNOL

JF - EUR J IMMUNOL

SN - 0014-2980

IS - 1

ER -