The complex role of the serotonin transporter in adult neurogenesis and neuroplasticity. A critical review
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The complex role of the serotonin transporter in adult neurogenesis and neuroplasticity. A critical review. / Benninghoff, Jens; van der Ven, Amelie; Schloesser, Robert J; Moessner, Rainald; Möller, Hans Jürgen; Rujescu, Dan.
in: WORLD J BIOL PSYCHIA, Jahrgang 13, Nr. 4, 04.2012, S. 240-7.Publikationen: SCORING: Beitrag in Fachzeitschrift/Zeitung › SCORING: Review › Forschung
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TY - JOUR
T1 - The complex role of the serotonin transporter in adult neurogenesis and neuroplasticity. A critical review
AU - Benninghoff, Jens
AU - van der Ven, Amelie
AU - Schloesser, Robert J
AU - Moessner, Rainald
AU - Möller, Hans Jürgen
AU - Rujescu, Dan
PY - 2012/4
Y1 - 2012/4
N2 - OBJECTIVES: Studies on the serotonin transporter (SERT) with regard to neurogenesis and neuroplastic effects on the adult brain are scarce. This is intriguing since neurogenesis is believed to play a decisive role in modulating the effect of selective serotonin reuptake inhibitors (SSRI), which are targeting SERT.METHODS: Therefore, we reviewed the current scientific literature about the influence of serotonin on neurogenesis with particular emphasis on SERT in various settings, both in vivo and in vitro.RESULTS: Experiments using SERT KO (knock-out) animal models showed that SERT does not directly or indirectly influence neurogenesis in vitro, whereas compensatory mechanism seem to participate in vivo.CONCLUSION: At least with regard to adult neural stem cells, the impact of serotonin (5-HT) on neuroplasticity and neurogenesis is not due to SERT-mediated effcts. Instead, serotonergic fine-tuning may be exerted by a number of other different mechanisms including endogenous production of 5-HT in adult neural stem cells, uptake of 5-HT into adult neural stem cells by other monoamine transporters, and actions of the 5-HT1A receptors present on these cells.
AB - OBJECTIVES: Studies on the serotonin transporter (SERT) with regard to neurogenesis and neuroplastic effects on the adult brain are scarce. This is intriguing since neurogenesis is believed to play a decisive role in modulating the effect of selective serotonin reuptake inhibitors (SSRI), which are targeting SERT.METHODS: Therefore, we reviewed the current scientific literature about the influence of serotonin on neurogenesis with particular emphasis on SERT in various settings, both in vivo and in vitro.RESULTS: Experiments using SERT KO (knock-out) animal models showed that SERT does not directly or indirectly influence neurogenesis in vitro, whereas compensatory mechanism seem to participate in vivo.CONCLUSION: At least with regard to adult neural stem cells, the impact of serotonin (5-HT) on neuroplasticity and neurogenesis is not due to SERT-mediated effcts. Instead, serotonergic fine-tuning may be exerted by a number of other different mechanisms including endogenous production of 5-HT in adult neural stem cells, uptake of 5-HT into adult neural stem cells by other monoamine transporters, and actions of the 5-HT1A receptors present on these cells.
KW - Adult
KW - Animals
KW - Humans
KW - Mice
KW - Mice, Knockout
KW - Neurogenesis/physiology
KW - Neuronal Plasticity/physiology
KW - Serotonin Plasma Membrane Transport Proteins/physiology
U2 - 10.3109/15622975.2011.640941
DO - 10.3109/15622975.2011.640941
M3 - SCORING: Review article
C2 - 22409535
VL - 13
SP - 240
EP - 247
JO - WORLD J BIOL PSYCHIA
JF - WORLD J BIOL PSYCHIA
SN - 1562-2975
IS - 4
ER -
