The clock genes Period 2 and Cryptochrome 2 differentially balance bone formation.
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The clock genes Period 2 and Cryptochrome 2 differentially balance bone formation. / Maronde, Erik; Schilling, Arndt; Seitz, Sebastian; Schinke, Thorsten; Schmutz, Isabelle; van der Horst, Gijsbertus; Amling, Michael; Albrecht, Urs.
in: PLOS ONE, Jahrgang 5, Nr. 7, 7, 2010, S. 11527.Publikationen: SCORING: Beitrag in Fachzeitschrift/Zeitung › SCORING: Zeitschriftenaufsatz › Forschung › Begutachtung
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TY - JOUR
T1 - The clock genes Period 2 and Cryptochrome 2 differentially balance bone formation.
AU - Maronde, Erik
AU - Schilling, Arndt
AU - Seitz, Sebastian
AU - Schinke, Thorsten
AU - Schmutz, Isabelle
AU - van der Horst, Gijsbertus
AU - Amling, Michael
AU - Albrecht, Urs
PY - 2010
Y1 - 2010
N2 - Clock genes and their protein products regulate circadian rhythms in mammals but have also been implicated in various physiological processes, including bone formation. Osteoblasts build new mineralized bone whereas osteoclasts degrade it thereby balancing bone formation. To evaluate the contribution of clock components in this process, we investigated mice mutant in clock genes for a bone volume phenotype.
AB - Clock genes and their protein products regulate circadian rhythms in mammals but have also been implicated in various physiological processes, including bone formation. Osteoblasts build new mineralized bone whereas osteoclasts degrade it thereby balancing bone formation. To evaluate the contribution of clock components in this process, we investigated mice mutant in clock genes for a bone volume phenotype.
KW - Animals
KW - Mice
KW - Mice, Mutant Strains
KW - Bone Density genetics
KW - Cryptochromes genetics
KW - Osteoblasts cytology
KW - Osteoclasts cytology
KW - Osteogenesis genetics
KW - Period Circadian Proteins genetics
KW - Animals
KW - Mice
KW - Mice, Mutant Strains
KW - Bone Density genetics
KW - Cryptochromes genetics
KW - Osteoblasts cytology
KW - Osteoclasts cytology
KW - Osteogenesis genetics
KW - Period Circadian Proteins genetics
U2 - 10.1371/journal.pone.0011527
DO - 10.1371/journal.pone.0011527
M3 - SCORING: Zeitschriftenaufsatz
VL - 5
SP - 11527
JO - PLOS ONE
JF - PLOS ONE
SN - 1932-6203
IS - 7
M1 - 7
ER -