The association of the appetitive peptide acetylated ghrelin with alcohol craving in early abstinent alcohol dependent individuals.
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The association of the appetitive peptide acetylated ghrelin with alcohol craving in early abstinent alcohol dependent individuals. / Koopmann, Anne; von der Goltz, Christoph; Grosshans, Martin; Dinter, Christina; Vitale, Meike; Wiedemann, Klaus; Kiefer, Falk.
in: PSYCHONEUROENDOCRINO, Jahrgang 37, Nr. 7, 7, 2012, S. 980-986.Publikationen: SCORING: Beitrag in Fachzeitschrift/Zeitung › SCORING: Zeitschriftenaufsatz › Forschung › Begutachtung
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TY - JOUR
T1 - The association of the appetitive peptide acetylated ghrelin with alcohol craving in early abstinent alcohol dependent individuals.
AU - Koopmann, Anne
AU - von der Goltz, Christoph
AU - Grosshans, Martin
AU - Dinter, Christina
AU - Vitale, Meike
AU - Wiedemann, Klaus
AU - Kiefer, Falk
PY - 2012
Y1 - 2012
N2 - Recent preclinical and clinical studies suggested ghrelin to have an orexigenic role in regulating appetite and energy balance. Preclinical studies also provided support for an important role of ghrelin in the neurobiology of addiction-related reward pathways, affecting the self-administration of alcohol and drugs as well as conditioned place preference. In contrast, clinical data have until now failed to support an association between ghrelin and alcohol craving, possibly due to the fact that these studies have analyzed the pharmacologically inactive, preprohormone ghrelin instead of ghrelin in its active, acetylated form.
AB - Recent preclinical and clinical studies suggested ghrelin to have an orexigenic role in regulating appetite and energy balance. Preclinical studies also provided support for an important role of ghrelin in the neurobiology of addiction-related reward pathways, affecting the self-administration of alcohol and drugs as well as conditioned place preference. In contrast, clinical data have until now failed to support an association between ghrelin and alcohol craving, possibly due to the fact that these studies have analyzed the pharmacologically inactive, preprohormone ghrelin instead of ghrelin in its active, acetylated form.
KW - Adult
KW - Humans
KW - Male
KW - Middle Aged
KW - Regression Analysis
KW - Psychological Tests
KW - Acetylation
KW - Alcohol Drinking/blood
KW - Alcoholism/blood/rehabilitation
KW - Appetite/physiology
KW - Behavior, Addictive/blood
KW - Ghrelin/blood/metabolism
KW - Obsessive Behavior/blood
KW - Substance Withdrawal Syndrome/blood
KW - Adult
KW - Humans
KW - Male
KW - Middle Aged
KW - Regression Analysis
KW - Psychological Tests
KW - Acetylation
KW - Alcohol Drinking/blood
KW - Alcoholism/blood/rehabilitation
KW - Appetite/physiology
KW - Behavior, Addictive/blood
KW - Ghrelin/blood/metabolism
KW - Obsessive Behavior/blood
KW - Substance Withdrawal Syndrome/blood
M3 - SCORING: Journal article
VL - 37
SP - 980
EP - 986
JO - PSYCHONEUROENDOCRINO
JF - PSYCHONEUROENDOCRINO
SN - 0306-4530
IS - 7
M1 - 7
ER -