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The association between ambient NO2 and PM2.5 with the respiratory health of school children residing in informal settlements: A prospective cohort study

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The association between ambient NO2 and PM2.5 with the respiratory health of school children residing in informal settlements: A prospective cohort study. / Olaniyan, Toyib; Jeebhay, Mohamed; Röösli, Martin; Naidoo, Rajen N; Künzli, Nino; de Hoogh, Kees; Saucy, Apolline; Badpa, Mahnaz; Baatjies, Roslynn; Parker, Bhawoodien; Leaner, Joy; Dalvie, Mohamed Aqiel.

in: ENVIRON RES, Jahrgang 186, 07.2020, S. 109606.

Publikationen: SCORING: Beitrag in Fachzeitschrift/Zeitung › SCORING: Zeitschriftenaufsatz › Forschung › Begutachtung

Harvard

Olaniyan, T, Jeebhay, M, Röösli, M, Naidoo, RN, Künzli, N, de Hoogh, K, Saucy, A, Badpa, M, Baatjies, R, Parker, B, Leaner, J & Dalvie, MA 2020, 'The association between ambient NO2 and PM2.5 with the respiratory health of school children residing in informal settlements: A prospective cohort study', ENVIRON RES, Jg. 186, S. 109606. https://doi.org/10.1016/j.envres.2020.109606

APA

Olaniyan, T., Jeebhay, M., Röösli, M., Naidoo, R. N., Künzli, N., de Hoogh, K., Saucy, A., Badpa, M., Baatjies, R., Parker, B., Leaner, J., & Dalvie, M. A. (2020). The association between ambient NO2 and PM2.5 with the respiratory health of school children residing in informal settlements: A prospective cohort study. ENVIRON RES, 186, 109606. https://doi.org/10.1016/j.envres.2020.109606

Vancouver

Olaniyan T, Jeebhay M, Röösli M, Naidoo RN, Künzli N, de Hoogh K et al. The association between ambient NO2 and PM2.5 with the respiratory health of school children residing in informal settlements: A prospective cohort study. ENVIRON RES. 2020 Jul;186:109606. https://doi.org/10.1016/j.envres.2020.109606

Bibtex

@article{e2411d524eba44e4af2a8edf7a1956f2,
title = "The association between ambient NO2 and PM2.5 with the respiratory health of school children residing in informal settlements: A prospective cohort study",
abstract = "BACKGROUND: No previous epidemiological study has investigated the combined association of long-term ambient nitrogen dioxide (NO2) and particulate matter of diameter size-2.5 (PM2.5) exposure with asthma outcomes among schoolchildren in Africa.OBJECTIVES: This study investigated the independent and co-pollutant association of long-term exposures to ambient air pollutants on asthma-associated outcomes in a cohort of schoolchildren in the Western Cape Province of South Africa.METHODS: A total of 590 grade-4 schoolchildren residing in four informal settlements were studied. Spirometry and fractional exhaled nitric-oxide (FeNO) measurements were conducted, including a standardized questionnaire administered to caregivers at baseline and 12-months follow-up. Annual NO2 and PM2.5 levels were estimated for each child's home using land-use regression modelling. Single- and two-pollutant models were constructed to assess the independent and co-pollutant association of both air pollutants (NO2 and PM2.5) on new cases of asthma-associated outcomes adjusting-for host characteristics, indoor exposures and study area.RESULTS: The annual average concentration of PM2.5 and NO2 were 10.01μg/m3 and 16.62μg/m3 respectively, across the four study areas, and were below the local Standards of 20μg/m3 and 40μg/m3, for both pollutants, respectively. In the two-pollutant-adjusted models, an interquartile range (IQR) increase of 14.2μg/m3 in NO2 was associated with an increased risk of new onset of ocular-nasal symptoms (adjusted odds ratio-aOR: 1.63, 95% CI: 1.01-2.60), wheezing (aOR: 3.57, 95% CI: 1.18-10.92), more than two or more asthma symptom score (aOR: 1.71, 95% CI: 1.02-2.86), and airway inflammation defined as FeNO > 35 ppb (aOR: 3.10, 95% CI: 1.10-8.71), independent of PM2.5 exposures.CONCLUSION: This study provided evidence that ambient NO2 levels below local standards and international guidelines, independent of PM2.5 exposure, increases new cases of asthma-associated outcomes after 12-months.",
keywords = "Air Pollutants/adverse effects, Air Pollution/adverse effects, Child, Environmental Exposure/adverse effects, Humans, Nitrogen Dioxide/analysis, Particulate Matter/analysis, Prospective Studies, South Africa/epidemiology",
author = "Toyib Olaniyan and Mohamed Jeebhay and Martin R{\"o}{\"o}sli and Naidoo, {Rajen N} and Nino K{\"u}nzli and {de Hoogh}, Kees and Apolline Saucy and Mahnaz Badpa and Roslynn Baatjies and Bhawoodien Parker and Joy Leaner and Dalvie, {Mohamed Aqiel}",
note = "Copyright {\textcopyright} 2020 Elsevier Inc. All rights reserved.",
year = "2020",
month = jul,
doi = "10.1016/j.envres.2020.109606",
language = "English",
volume = "186",
pages = "109606",
journal = "ENVIRON RES",
issn = "0013-9351",
publisher = "Academic Press Inc.",

}

RIS

TY - JOUR

T1 - The association between ambient NO2 and PM2.5 with the respiratory health of school children residing in informal settlements: A prospective cohort study

AU - Olaniyan, Toyib

AU - Jeebhay, Mohamed

AU - Röösli, Martin

AU - Naidoo, Rajen N

AU - Künzli, Nino

AU - de Hoogh, Kees

AU - Saucy, Apolline

AU - Badpa, Mahnaz

AU - Baatjies, Roslynn

AU - Parker, Bhawoodien

AU - Leaner, Joy

AU - Dalvie, Mohamed Aqiel

N1 - Copyright © 2020 Elsevier Inc. All rights reserved.

PY - 2020/7

Y1 - 2020/7

N2 - BACKGROUND: No previous epidemiological study has investigated the combined association of long-term ambient nitrogen dioxide (NO2) and particulate matter of diameter size-2.5 (PM2.5) exposure with asthma outcomes among schoolchildren in Africa.OBJECTIVES: This study investigated the independent and co-pollutant association of long-term exposures to ambient air pollutants on asthma-associated outcomes in a cohort of schoolchildren in the Western Cape Province of South Africa.METHODS: A total of 590 grade-4 schoolchildren residing in four informal settlements were studied. Spirometry and fractional exhaled nitric-oxide (FeNO) measurements were conducted, including a standardized questionnaire administered to caregivers at baseline and 12-months follow-up. Annual NO2 and PM2.5 levels were estimated for each child's home using land-use regression modelling. Single- and two-pollutant models were constructed to assess the independent and co-pollutant association of both air pollutants (NO2 and PM2.5) on new cases of asthma-associated outcomes adjusting-for host characteristics, indoor exposures and study area.RESULTS: The annual average concentration of PM2.5 and NO2 were 10.01μg/m3 and 16.62μg/m3 respectively, across the four study areas, and were below the local Standards of 20μg/m3 and 40μg/m3, for both pollutants, respectively. In the two-pollutant-adjusted models, an interquartile range (IQR) increase of 14.2μg/m3 in NO2 was associated with an increased risk of new onset of ocular-nasal symptoms (adjusted odds ratio-aOR: 1.63, 95% CI: 1.01-2.60), wheezing (aOR: 3.57, 95% CI: 1.18-10.92), more than two or more asthma symptom score (aOR: 1.71, 95% CI: 1.02-2.86), and airway inflammation defined as FeNO > 35 ppb (aOR: 3.10, 95% CI: 1.10-8.71), independent of PM2.5 exposures.CONCLUSION: This study provided evidence that ambient NO2 levels below local standards and international guidelines, independent of PM2.5 exposure, increases new cases of asthma-associated outcomes after 12-months.

AB - BACKGROUND: No previous epidemiological study has investigated the combined association of long-term ambient nitrogen dioxide (NO2) and particulate matter of diameter size-2.5 (PM2.5) exposure with asthma outcomes among schoolchildren in Africa.OBJECTIVES: This study investigated the independent and co-pollutant association of long-term exposures to ambient air pollutants on asthma-associated outcomes in a cohort of schoolchildren in the Western Cape Province of South Africa.METHODS: A total of 590 grade-4 schoolchildren residing in four informal settlements were studied. Spirometry and fractional exhaled nitric-oxide (FeNO) measurements were conducted, including a standardized questionnaire administered to caregivers at baseline and 12-months follow-up. Annual NO2 and PM2.5 levels were estimated for each child's home using land-use regression modelling. Single- and two-pollutant models were constructed to assess the independent and co-pollutant association of both air pollutants (NO2 and PM2.5) on new cases of asthma-associated outcomes adjusting-for host characteristics, indoor exposures and study area.RESULTS: The annual average concentration of PM2.5 and NO2 were 10.01μg/m3 and 16.62μg/m3 respectively, across the four study areas, and were below the local Standards of 20μg/m3 and 40μg/m3, for both pollutants, respectively. In the two-pollutant-adjusted models, an interquartile range (IQR) increase of 14.2μg/m3 in NO2 was associated with an increased risk of new onset of ocular-nasal symptoms (adjusted odds ratio-aOR: 1.63, 95% CI: 1.01-2.60), wheezing (aOR: 3.57, 95% CI: 1.18-10.92), more than two or more asthma symptom score (aOR: 1.71, 95% CI: 1.02-2.86), and airway inflammation defined as FeNO > 35 ppb (aOR: 3.10, 95% CI: 1.10-8.71), independent of PM2.5 exposures.CONCLUSION: This study provided evidence that ambient NO2 levels below local standards and international guidelines, independent of PM2.5 exposure, increases new cases of asthma-associated outcomes after 12-months.

KW - Air Pollutants/adverse effects

KW - Air Pollution/adverse effects

KW - Child

KW - Environmental Exposure/adverse effects

KW - Humans

KW - Nitrogen Dioxide/analysis

KW - Particulate Matter/analysis

KW - Prospective Studies

KW - South Africa/epidemiology

U2 - 10.1016/j.envres.2020.109606

DO - 10.1016/j.envres.2020.109606

M3 - SCORING: Journal article

C2 - 32371276

VL - 186

SP - 109606

JO - ENVIRON RES

JF - ENVIRON RES

SN - 0013-9351

ER -