Temporal Sharpening of Sensory Responses by Layer V in the Mouse Primary Somatosensory Cortex
Abstract
The timing of stimulus-evoked spikes encodes information about sensory stimuli. Here we studied the neural circuits controlling this process in the mouse primary somatosensory cortex. We found that brief optogenetic activation of layer V pyramidal cells just after whisker deflection modulated the membrane potential of neurons and interrupted their long-latency whisker responses, increasing their accuracy in encoding whisker deflection time. In contrast, optogenetic inhibition of layer V during either passive whisker deflection or active whisking decreased accuracy in encoding stimulus or touch time, respectively. Suppression of layer V pyramidal cells increased reaction times in a texture discrimination task. Moreover, two-color optogenetic experiments revealed that cortical inhibition was efficiently recruited by layer V stimulation and that it mainly involved activation of parvalbumin-positive rather than somatostatin-positive interneurons. Layer V thus performs behaviorally relevant temporal sharpening of sensory responses through circuit-specific recruitment of cortical inhibition.
Bibliografische Daten
Originalsprache | Englisch |
---|---|
ISSN | 0960-9822 |
DOIs | |
Status | Veröffentlicht - 04.05.2020 |
Extern publiziert | Ja |
Anmerkungen des Dekanats
Copyright © 2020 The Author(s). Published by Elsevier Inc. All rights reserved.
PubMed | 32169206 |
---|