Temporal control of immediate early gene induction by light.
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Temporal control of immediate early gene induction by light. / Schoenenberger, Philipp; Gerosa, Daniela; Oertner, Thomas G.
in: PLOS ONE, Jahrgang 4, Nr. 12, 12, 2009, S. 8185.Publikationen: SCORING: Beitrag in Fachzeitschrift/Zeitung › SCORING: Zeitschriftenaufsatz › Forschung › Begutachtung
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TY - JOUR
T1 - Temporal control of immediate early gene induction by light.
AU - Schoenenberger, Philipp
AU - Gerosa, Daniela
AU - Oertner, Thomas G.
PY - 2009
Y1 - 2009
N2 - The light-gated cation channel channelrhodopsin-2 (ChR2) is a powerful tool for the optical induction of action potentials in neurons. Mutations of the cysteine 128 (C128) residue have been shown to greatly extend the lifetime of the conducting state of ChR2. However, until now, only subthreshold depolarizations have been reported from C128 mutants.
AB - The light-gated cation channel channelrhodopsin-2 (ChR2) is a powerful tool for the optical induction of action potentials in neurons. Mutations of the cysteine 128 (C128) residue have been shown to greatly extend the lifetime of the conducting state of ChR2. However, until now, only subthreshold depolarizations have been reported from C128 mutants.
KW - Animals
KW - Time Factors
KW - Mice
KW - Rats
KW - Light
KW - Action Potentials/radiation effects
KW - Cell Adhesion/radiation effects
KW - Gene Expression Regulation/radiation effects
KW - Genes, Immediate-Early/genetics
KW - Ion Channel Gating/radiation effects
KW - Mutation/genetics
KW - Organ Specificity/radiation effects
KW - Proto-Oncogene Proteins c-fos/genetics/metabolism
KW - Pyramidal Cells/cytology/metabolism/radiation effects
KW - Rhodopsin/genetics
KW - Animals
KW - Time Factors
KW - Mice
KW - Rats
KW - Light
KW - Action Potentials/radiation effects
KW - Cell Adhesion/radiation effects
KW - Gene Expression Regulation/radiation effects
KW - Genes, Immediate-Early/genetics
KW - Ion Channel Gating/radiation effects
KW - Mutation/genetics
KW - Organ Specificity/radiation effects
KW - Proto-Oncogene Proteins c-fos/genetics/metabolism
KW - Pyramidal Cells/cytology/metabolism/radiation effects
KW - Rhodopsin/genetics
M3 - SCORING: Journal article
VL - 4
SP - 8185
JO - PLOS ONE
JF - PLOS ONE
SN - 1932-6203
IS - 12
M1 - 12
ER -