Targeting the Gremlin-VEGFR2 axis - a promising strategy for multiple diseases?

Robert Erdmann; Cansu Ozden; Jens Weidmann; Alexander Schultze

doi:10.1002/path.4544

Targeting the Gremlin-VEGFR2 axis - a promising strategy for multiple diseases?

Robert Erdmann (Geteilte/r Erstautor/in)
Cansu Ozden (Geteilte/r Erstautor/in)
Jens Weidmann
Alexander Schultze

Beteiligte Einrichtungen

II. Medizinische Klinik und Poliklinik
Institut für Pathologie

Abstract

Published recently in the Journal of Pathology, Lavoz et al. show that Gremlin promotes renal inflammation directly via VEGFR2. As Gremlin has been implicated in many other diseases, such as heart, lung and liver fibrosis, osteogenesis, angiogenesis and cancer, the new findings provide a rationale for novel concepts to investigate and potentially treat several pathologies.

Bibliografische Daten

Originalsprache	Englisch
ISSN	0022-3417
DOIs	https://doi.org/10.1002/path.4544
Status	Veröffentlicht - 08.2015

PubMed	25875212