Targeting the Gremlin-VEGFR2 axis - a promising strategy for multiple diseases?

Abstract

Published recently in the Journal of Pathology, Lavoz et al. show that Gremlin promotes renal inflammation directly via VEGFR2. As Gremlin has been implicated in many other diseases, such as heart, lung and liver fibrosis, osteogenesis, angiogenesis and cancer, the new findings provide a rationale for novel concepts to investigate and potentially treat several pathologies.

Bibliografische Daten

OriginalspracheEnglisch
ISSN0022-3417
DOIs
StatusVeröffentlicht - 08.2015
PubMed 25875212