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Tailor-made quantum dot and iron oxide based contrast agents for in vitro and in vivo tumor imaging.

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Tailor-made quantum dot and iron oxide based contrast agents for in vitro and in vivo tumor imaging. / Pöselt, Elmar; Schmidtke, Christian; Fischer, Steffen; Peldschus, Kersten; Salamon, Johannes Martin; Kloust, Hauke; Tran, Huong; Pietsch, Andrea; Heine, Markus; Adam, Gerhard; Schumacher, Udo; Wagener, Christoph; Förster, Stephan; Weller, Horst.

in: ACS NANO, Jahrgang 6, Nr. 4, 4, 2012, S. 3346-3355.

Publikationen: SCORING: Beitrag in Fachzeitschrift/Zeitung › SCORING: Zeitschriftenaufsatz › Forschung › Begutachtung

Harvard

Pöselt, E, Schmidtke, C, Fischer, S, Peldschus, K, Salamon, JM, Kloust, H, Tran, H, Pietsch, A, Heine, M, Adam, G, Schumacher, U, Wagener, C, Förster, S & Weller, H 2012, 'Tailor-made quantum dot and iron oxide based contrast agents for in vitro and in vivo tumor imaging.', ACS NANO, Jg. 6, Nr. 4, 4, S. 3346-3355. <http://www.ncbi.nlm.nih.gov/pubmed/22463104?dopt=Citation>

APA

Pöselt, E., Schmidtke, C., Fischer, S., Peldschus, K., Salamon, J. M., Kloust, H., Tran, H., Pietsch, A., Heine, M., Adam, G., Schumacher, U., Wagener, C., Förster, S., & Weller, H. (2012). Tailor-made quantum dot and iron oxide based contrast agents for in vitro and in vivo tumor imaging. ACS NANO, 6(4), 3346-3355. [4]. http://www.ncbi.nlm.nih.gov/pubmed/22463104?dopt=Citation

Vancouver

Pöselt E, Schmidtke C, Fischer S, Peldschus K, Salamon JM, Kloust H et al. Tailor-made quantum dot and iron oxide based contrast agents for in vitro and in vivo tumor imaging. ACS NANO. 2012;6(4):3346-3355. 4.

Bibtex

@article{52e26c2431f743048044be998ef32580,
title = "Tailor-made quantum dot and iron oxide based contrast agents for in vitro and in vivo tumor imaging.",
abstract = "The biofunctionalization of CdSe/CdS/ZnS quantum dots and Fe(3)O(4) nanocrystals using a novel ligand system based on polyisoprene-block-poly(ethylene oxide) ligands is described. The synthesis includes a partial ligand exchange of the hydrophobic nanocrystals with amino-functionalized polyisoprene ligands, followed by seeded micelle formation of the diblock-copolymers in water. The resulting water-soluble quantum dots showed fluorescence quantum efficiencies in the 40 to 50% range and extraordinary fluorescence stability in the biological environment after cross-linking of the polyisoprene moiety of the ligand shell. No toxicity was detected by water-soluble tetrazolium (WST8) and lactate dehydrogenase (LDH) assays, even at very high nanoparticle concentrations, and almost no nonspecific cell adhesion was detected. The ligand shell was further coupled to the antigen-related cell adhesion molecule (CEACAM) specific monoclonal antibody T84.1. The so-conjugated Fe(3)O(4) nanocrystals allowed in vitro and in vivo tumor targeting by magnetic resonance imaging.",
author = "Elmar P{\"o}selt and Christian Schmidtke and Steffen Fischer and Kersten Peldschus and Salamon, {Johannes Martin} and Hauke Kloust and Huong Tran and Andrea Pietsch and Markus Heine and Gerhard Adam and Udo Schumacher and Christoph Wagener and Stephan F{\"o}rster and Horst Weller",
year = "2012",
language = "English",
volume = "6",
pages = "3346--3355",
journal = "ACS NANO",
issn = "1936-0851",
publisher = "American Chemical Society",
number = "4",

}

RIS

TY - JOUR

T1 - Tailor-made quantum dot and iron oxide based contrast agents for in vitro and in vivo tumor imaging.

AU - Pöselt, Elmar

AU - Schmidtke, Christian

AU - Fischer, Steffen

AU - Peldschus, Kersten

AU - Salamon, Johannes Martin

AU - Kloust, Hauke

AU - Tran, Huong

AU - Pietsch, Andrea

AU - Heine, Markus

AU - Adam, Gerhard

AU - Schumacher, Udo

AU - Wagener, Christoph

AU - Förster, Stephan

AU - Weller, Horst

PY - 2012

Y1 - 2012

N2 - The biofunctionalization of CdSe/CdS/ZnS quantum dots and Fe(3)O(4) nanocrystals using a novel ligand system based on polyisoprene-block-poly(ethylene oxide) ligands is described. The synthesis includes a partial ligand exchange of the hydrophobic nanocrystals with amino-functionalized polyisoprene ligands, followed by seeded micelle formation of the diblock-copolymers in water. The resulting water-soluble quantum dots showed fluorescence quantum efficiencies in the 40 to 50% range and extraordinary fluorescence stability in the biological environment after cross-linking of the polyisoprene moiety of the ligand shell. No toxicity was detected by water-soluble tetrazolium (WST8) and lactate dehydrogenase (LDH) assays, even at very high nanoparticle concentrations, and almost no nonspecific cell adhesion was detected. The ligand shell was further coupled to the antigen-related cell adhesion molecule (CEACAM) specific monoclonal antibody T84.1. The so-conjugated Fe(3)O(4) nanocrystals allowed in vitro and in vivo tumor targeting by magnetic resonance imaging.

AB - The biofunctionalization of CdSe/CdS/ZnS quantum dots and Fe(3)O(4) nanocrystals using a novel ligand system based on polyisoprene-block-poly(ethylene oxide) ligands is described. The synthesis includes a partial ligand exchange of the hydrophobic nanocrystals with amino-functionalized polyisoprene ligands, followed by seeded micelle formation of the diblock-copolymers in water. The resulting water-soluble quantum dots showed fluorescence quantum efficiencies in the 40 to 50% range and extraordinary fluorescence stability in the biological environment after cross-linking of the polyisoprene moiety of the ligand shell. No toxicity was detected by water-soluble tetrazolium (WST8) and lactate dehydrogenase (LDH) assays, even at very high nanoparticle concentrations, and almost no nonspecific cell adhesion was detected. The ligand shell was further coupled to the antigen-related cell adhesion molecule (CEACAM) specific monoclonal antibody T84.1. The so-conjugated Fe(3)O(4) nanocrystals allowed in vitro and in vivo tumor targeting by magnetic resonance imaging.

M3 - SCORING: Journal article

VL - 6

SP - 3346

EP - 3355

JO - ACS NANO

JF - ACS NANO

SN - 1936-0851

IS - 4

M1 - 4

ER -