T Cell Repertoire Dynamics during Pregnancy in Multiple Sclerosis

Caren Ramien; Erik C Yusko; Jan Broder Engler; Stefanie Gamradt; Kostas Patas; Nils Schweingruber; Anne Willing; Sina Cathérine Rosenkranz; Anke Diemert; Anja Harrison; Marissa Vignali; Catherine Sanders; Harlan S Robins; Eva Tolosa; Christoph Heesen; Petra C Arck; Alexander Scheffold; Kenneth Chan; Ryan O Emerson; Manuel A Friese; Stefan M Gold

doi:10.1016/j.celrep.2019.09.025

T Cell Repertoire Dynamics during Pregnancy in Multiple Sclerosis

Standard

T Cell Repertoire Dynamics during Pregnancy in Multiple Sclerosis. / Ramien, Caren; Yusko, Erik C; Engler, Jan Broder; Gamradt, Stefanie; Patas, Kostas; Schweingruber, Nils ; Willing, Anne ; Rosenkranz, Sina Cathérine ; Diemert, Anke; Harrison, Anja; Vignali, Marissa; Sanders, Catherine; Robins, Harlan S; Tolosa, Eva ; Heesen, Christoph ; Arck, Petra C; Scheffold, Alexander; Chan, Kenneth; Emerson, Ryan O; Friese, Manuel A; Gold, Stefan M.

in: CELL REP, Jahrgang 29, Nr. 4, 22.10.2019, S. 810-815.e4.

Publikationen: SCORING: Beitrag in Fachzeitschrift/Zeitung › SCORING: Zeitschriftenaufsatz › Forschung › Begutachtung

Harvard

Ramien, C, Yusko, EC, Engler, JB, Gamradt, S, Patas, K, Schweingruber, N , Willing, A , Rosenkranz, SC , Diemert, A, Harrison, A, Vignali, M, Sanders, C, Robins, HS, Tolosa, E , Heesen, C , Arck, PC, Scheffold, A, Chan, K, Emerson, RO, Friese, MA & Gold, SM 2019, 'T Cell Repertoire Dynamics during Pregnancy in Multiple Sclerosis', CELL REP, Jg. 29, Nr. 4, S. 810-815.e4. https://doi.org/10.1016/j.celrep.2019.09.025

APA

Ramien, C., Yusko, E. C., Engler, J. B., Gamradt, S., Patas, K., Schweingruber, N., Willing, A., Rosenkranz, S. C., Diemert, A., Harrison, A., Vignali, M., Sanders, C., Robins, H. S., Tolosa, E., Heesen, C., Arck, P. C., Scheffold, A., Chan, K., Emerson, R. O., ... Gold, S. M. (2019). T Cell Repertoire Dynamics during Pregnancy in Multiple Sclerosis. CELL REP, 29(4), 810-815.e4. https://doi.org/10.1016/j.celrep.2019.09.025

Vancouver

Ramien C, Yusko EC, Engler JB, Gamradt S, Patas K, Schweingruber N et al. T Cell Repertoire Dynamics during Pregnancy in Multiple Sclerosis. CELL REP. 2019 Okt 22;29(4):810-815.e4. https://doi.org/10.1016/j.celrep.2019.09.025

Bibtex

@article{e43aa76603dc4a04b17b0864604f19b5,

title = "T Cell Repertoire Dynamics during Pregnancy in Multiple Sclerosis",

abstract = "Identifying T cell clones associated with human autoimmunity has remained challenging. Intriguingly, many autoimmune diseases, including multiple sclerosis (MS), show strongly diminished activity during pregnancy, providing a unique research paradigm to explore dynamics of immune repertoire changes during active and inactive disease. Here, we characterize immunomodulation at the single-clone level by sequencing the T cell repertoire in healthy women and female MS patients over the course of pregnancy. Clonality is significantly reduced from the first to third trimester in MS patients, indicating that the T cell repertoire becomes less dominated by expanded clones. However, only a few T cell clones are substantially modulated during pregnancy in each patient. Moreover, relapse-associated T cell clones identified in an individual patient contract during pregnancy and expand during a postpartum relapse. Our data provide evidence that profiling the T cell repertoire during pregnancy could serve as a tool to discover and track {"}private{"} T cell clones associated with disease activity in autoimmunity.",

author = "Caren Ramien and Yusko, {Erik C} and Engler, {Jan Broder} and Stefanie Gamradt and Kostas Patas and Nils Schweingruber and Anne Willing and Rosenkranz, {Sina Cath{\'e}rine} and Anke Diemert and Anja Harrison and Marissa Vignali and Catherine Sanders and Robins, {Harlan S} and Eva Tolosa and Christoph Heesen and Arck, {Petra C} and Alexander Scheffold and Kenneth Chan and Emerson, {Ryan O} and Friese, {Manuel A} and Gold, {Stefan M}",

year = "2019",

month = oct,

day = "22",

doi = "10.1016/j.celrep.2019.09.025",

language = "English",

volume = "29",

pages = "810--815.e4",

journal = "CELL REP",

issn = "2211-1247",

publisher = "Elsevier",

number = "4",

}

RIS

TY - JOUR

T1 - T Cell Repertoire Dynamics during Pregnancy in Multiple Sclerosis

AU - Ramien, Caren

AU - Yusko, Erik C

AU - Engler, Jan Broder

AU - Gamradt, Stefanie

AU - Patas, Kostas

AU - Schweingruber, Nils

AU - Willing, Anne

AU - Rosenkranz, Sina Cathérine

AU - Diemert, Anke

AU - Harrison, Anja

AU - Vignali, Marissa

AU - Sanders, Catherine

AU - Robins, Harlan S

AU - Tolosa, Eva

AU - Heesen, Christoph

AU - Arck, Petra C

AU - Scheffold, Alexander

AU - Chan, Kenneth

AU - Emerson, Ryan O

AU - Friese, Manuel A

AU - Gold, Stefan M

PY - 2019/10/22

Y1 - 2019/10/22

N2 - Identifying T cell clones associated with human autoimmunity has remained challenging. Intriguingly, many autoimmune diseases, including multiple sclerosis (MS), show strongly diminished activity during pregnancy, providing a unique research paradigm to explore dynamics of immune repertoire changes during active and inactive disease. Here, we characterize immunomodulation at the single-clone level by sequencing the T cell repertoire in healthy women and female MS patients over the course of pregnancy. Clonality is significantly reduced from the first to third trimester in MS patients, indicating that the T cell repertoire becomes less dominated by expanded clones. However, only a few T cell clones are substantially modulated during pregnancy in each patient. Moreover, relapse-associated T cell clones identified in an individual patient contract during pregnancy and expand during a postpartum relapse. Our data provide evidence that profiling the T cell repertoire during pregnancy could serve as a tool to discover and track "private" T cell clones associated with disease activity in autoimmunity.

AB - Identifying T cell clones associated with human autoimmunity has remained challenging. Intriguingly, many autoimmune diseases, including multiple sclerosis (MS), show strongly diminished activity during pregnancy, providing a unique research paradigm to explore dynamics of immune repertoire changes during active and inactive disease. Here, we characterize immunomodulation at the single-clone level by sequencing the T cell repertoire in healthy women and female MS patients over the course of pregnancy. Clonality is significantly reduced from the first to third trimester in MS patients, indicating that the T cell repertoire becomes less dominated by expanded clones. However, only a few T cell clones are substantially modulated during pregnancy in each patient. Moreover, relapse-associated T cell clones identified in an individual patient contract during pregnancy and expand during a postpartum relapse. Our data provide evidence that profiling the T cell repertoire during pregnancy could serve as a tool to discover and track "private" T cell clones associated with disease activity in autoimmunity.

U2 - 10.1016/j.celrep.2019.09.025

DO - 10.1016/j.celrep.2019.09.025

M3 - SCORING: Journal article

C2 - 31644905

VL - 29

SP - 810-815.e4

JO - CELL REP

JF - CELL REP

SN - 2211-1247

IS - 4

ER -