Systematic evaluation of stroke thrombectomy in clinical practice: The German Stroke Registry Endovascular Treatment
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Systematic evaluation of stroke thrombectomy in clinical practice: The German Stroke Registry Endovascular Treatment. / Alegiani, Anna C; Dorn, Franziska; Herzberg, Moriz; Wollenweber, Frank A; Kellert, Lars; Siebert, Eberhard; Nolte, Christian H; von Rennenberg, Regina; Hattingen, Elke; Petzold, Gabor C; Bode, Felix J; Pfeilschifter, Waltraud; Schäfer, Jan H; Wagner, Marlies; Röther, Joachim; Eckert, Bernd; Kraft, Peter; Pham, Mirko; Boeckh-Behrens, Tobias; Wunderlich, Silke; Bernkopf, Kathleen; Reich, Arno; Wiesmann, Martin; Mpotsaris, Anastasios; Psychogios, Marios; Liman, Jan; Maier, Ilko; Berrouschot, Jörg; Bormann, Albrecht; Limmroth, Volker; Spreer, Joachim; Petersen, Martina; Krause, Lars; Lowens, Stephan; Kraemer, Christoffer; Zweynert, Sarah; Lange, Kristin S; Thonke, Sven; Kastrup, Andreas; Papanagiotou, Panagiotis; Alber, Burkhard; Braun, Michael; Fiehler, Jens; Gerloff, Christian; Dichgans, Martin; Thomalla, Götz.
in: INT J STROKE, Jahrgang 14, Nr. 4, 06.2019, S. 372-380.Publikationen: SCORING: Beitrag in Fachzeitschrift/Zeitung › SCORING: Zeitschriftenaufsatz › Forschung › Begutachtung
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TY - JOUR
T1 - Systematic evaluation of stroke thrombectomy in clinical practice: The German Stroke Registry Endovascular Treatment
AU - Alegiani, Anna C
AU - Dorn, Franziska
AU - Herzberg, Moriz
AU - Wollenweber, Frank A
AU - Kellert, Lars
AU - Siebert, Eberhard
AU - Nolte, Christian H
AU - von Rennenberg, Regina
AU - Hattingen, Elke
AU - Petzold, Gabor C
AU - Bode, Felix J
AU - Pfeilschifter, Waltraud
AU - Schäfer, Jan H
AU - Wagner, Marlies
AU - Röther, Joachim
AU - Eckert, Bernd
AU - Kraft, Peter
AU - Pham, Mirko
AU - Boeckh-Behrens, Tobias
AU - Wunderlich, Silke
AU - Bernkopf, Kathleen
AU - Reich, Arno
AU - Wiesmann, Martin
AU - Mpotsaris, Anastasios
AU - Psychogios, Marios
AU - Liman, Jan
AU - Maier, Ilko
AU - Berrouschot, Jörg
AU - Bormann, Albrecht
AU - Limmroth, Volker
AU - Spreer, Joachim
AU - Petersen, Martina
AU - Krause, Lars
AU - Lowens, Stephan
AU - Kraemer, Christoffer
AU - Zweynert, Sarah
AU - Lange, Kristin S
AU - Thonke, Sven
AU - Kastrup, Andreas
AU - Papanagiotou, Panagiotis
AU - Alber, Burkhard
AU - Braun, Michael
AU - Fiehler, Jens
AU - Gerloff, Christian
AU - Dichgans, Martin
AU - Thomalla, Götz
PY - 2019/6
Y1 - 2019/6
N2 - BACKGROUND: Endovascular treatment has become standard of care for the treatment of acute ischemic stroke with large vessel occlusion. However, patients treated in clinical practice differ from the selected populations randomized in clinical trials.AIMS: The German Stroke Registry Endovascular Treatment (GSR-ET) aims at a systematic evaluation of outcome, safety, and process parameters of endovascular stroke treatment in standard of care in Germany.METHODS: The GSR-ET is an academic, independent, prospective, multicenter, observational registry study. Participating stroke centers from all over of Germany consecutively enroll patients transferred to the angiography suite with an intention to be treated with endovascular stroke treatment. Patients receive regular care. Data are collected as part of clinical routine. Baseline clinical and procedural information and clinical follow-up information after 90 days are recorded. Here, we present an analysis of baseline data of the first 1662 patients included in the GSR-ET.RESULTS: The registry was established in June 2015. By 31 December 2017, 1662 patients were enrolled in 23 active sites. Mean age was 72 ± 13 years, 50% were female, and median National Institutes of Health Stroke Scale on admission was 15 (IQR 10-19), 88% had anterior circulation occlusion. Median ASPECT score was 8 (IQR 7-10) prior to intervention. Fifty-nine percent of patients received intravenous thrombolysis prior to thrombectomy. Mean "onset-to-groin" time was 224 ± 176 min.CONCLUSIONS: Baseline characteristics of stroke patients undergoing thrombectomy in clinical practice differ from those in the randomized trials. The GSR-ET will provide valuable insights into practices of endovascular treatment in routine care of acute ischemic stroke. (GSR-ET ClinicalTrials.gov Identifier: NCT03356392.).
AB - BACKGROUND: Endovascular treatment has become standard of care for the treatment of acute ischemic stroke with large vessel occlusion. However, patients treated in clinical practice differ from the selected populations randomized in clinical trials.AIMS: The German Stroke Registry Endovascular Treatment (GSR-ET) aims at a systematic evaluation of outcome, safety, and process parameters of endovascular stroke treatment in standard of care in Germany.METHODS: The GSR-ET is an academic, independent, prospective, multicenter, observational registry study. Participating stroke centers from all over of Germany consecutively enroll patients transferred to the angiography suite with an intention to be treated with endovascular stroke treatment. Patients receive regular care. Data are collected as part of clinical routine. Baseline clinical and procedural information and clinical follow-up information after 90 days are recorded. Here, we present an analysis of baseline data of the first 1662 patients included in the GSR-ET.RESULTS: The registry was established in June 2015. By 31 December 2017, 1662 patients were enrolled in 23 active sites. Mean age was 72 ± 13 years, 50% were female, and median National Institutes of Health Stroke Scale on admission was 15 (IQR 10-19), 88% had anterior circulation occlusion. Median ASPECT score was 8 (IQR 7-10) prior to intervention. Fifty-nine percent of patients received intravenous thrombolysis prior to thrombectomy. Mean "onset-to-groin" time was 224 ± 176 min.CONCLUSIONS: Baseline characteristics of stroke patients undergoing thrombectomy in clinical practice differ from those in the randomized trials. The GSR-ET will provide valuable insights into practices of endovascular treatment in routine care of acute ischemic stroke. (GSR-ET ClinicalTrials.gov Identifier: NCT03356392.).
KW - Journal Article
U2 - 10.1177/1747493018806199
DO - 10.1177/1747493018806199
M3 - SCORING: Journal article
C2 - 30346260
VL - 14
SP - 372
EP - 380
JO - INT J STROKE
JF - INT J STROKE
SN - 1747-4930
IS - 4
ER -