Surface conditioning with cold argon plasma and its effect on the osseointegration of dental implants in miniature pigs
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Surface conditioning with cold argon plasma and its effect on the osseointegration of dental implants in miniature pigs. / Naujokat, Hendrik; Harder, Sönke; Schulz, Lara Yasemin; Wiltfang, Jörg; Flörke, Christian; Açil, Yahya.
in: J CRANIO MAXILL SURG, Jahrgang 47, Nr. 3, 03.2019, S. 484-490.Publikationen: SCORING: Beitrag in Fachzeitschrift/Zeitung › SCORING: Zeitschriftenaufsatz › Forschung › Begutachtung
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TY - JOUR
T1 - Surface conditioning with cold argon plasma and its effect on the osseointegration of dental implants in miniature pigs
AU - Naujokat, Hendrik
AU - Harder, Sönke
AU - Schulz, Lara Yasemin
AU - Wiltfang, Jörg
AU - Flörke, Christian
AU - Açil, Yahya
N1 - Copyright © 2018 European Association for Cranio-Maxillo-Facial Surgery. Published by Elsevier Ltd. All rights reserved.
PY - 2019/3
Y1 - 2019/3
N2 - PURPOSE: Successful implant therapy is based on fast, safe, and predictable osseointegration. Several surface modifications have been introduced to improve the bone-to-implant interaction. This in vivo study evaluates the impact of plasma surface conditioning on early wound healing and osseointegration.MATERIALS AND METHODS: A total of 16 dental implants with a sand-blasted and acid-etched surface were conditioned with cold atmospheric plasma prior to insertion in the frontal bone of four miniature pigs. Sequential fluorescence labeling was administered to label bone metabolism, and after 8 weeks, bone blocks were harvested for radiological, histological, and histomorphometrical evaluation.RESULTS: The plasma conditioning had no impact on the morphology of the implant surface. The bone-to-implant contact ratio was 90.4% and 86.5%, the interthread bone density 72.5% and 63.4%, and the periimplant bone density 60.5% and 61.1%, in the plasma conditioned group and control group, respectively. Concentric bands of fluorescence enrichment indicated a chronological and homogenous mineralization of newly formed bone. No unwanted periimplant side effects were detected.CONCLUSION: The increased parameters for osseointegration in this in vivo study merit further investigation in prospective clinical trials.
AB - PURPOSE: Successful implant therapy is based on fast, safe, and predictable osseointegration. Several surface modifications have been introduced to improve the bone-to-implant interaction. This in vivo study evaluates the impact of plasma surface conditioning on early wound healing and osseointegration.MATERIALS AND METHODS: A total of 16 dental implants with a sand-blasted and acid-etched surface were conditioned with cold atmospheric plasma prior to insertion in the frontal bone of four miniature pigs. Sequential fluorescence labeling was administered to label bone metabolism, and after 8 weeks, bone blocks were harvested for radiological, histological, and histomorphometrical evaluation.RESULTS: The plasma conditioning had no impact on the morphology of the implant surface. The bone-to-implant contact ratio was 90.4% and 86.5%, the interthread bone density 72.5% and 63.4%, and the periimplant bone density 60.5% and 61.1%, in the plasma conditioned group and control group, respectively. Concentric bands of fluorescence enrichment indicated a chronological and homogenous mineralization of newly formed bone. No unwanted periimplant side effects were detected.CONCLUSION: The increased parameters for osseointegration in this in vivo study merit further investigation in prospective clinical trials.
KW - Acid Etching, Dental
KW - Animals
KW - Argon
KW - Bone Density
KW - Dental Implantation, Endosseous
KW - Dental Implants
KW - Dental Prosthesis Design
KW - Microscopy, Electron, Scanning
KW - Microscopy, Fluorescence
KW - Models, Animal
KW - Osseointegration
KW - Plasma Gases
KW - Surface Properties
KW - Swine
KW - Swine, Miniature
KW - Titanium
KW - Wound Healing
U2 - 10.1016/j.jcms.2018.12.011
DO - 10.1016/j.jcms.2018.12.011
M3 - SCORING: Journal article
C2 - 30661927
VL - 47
SP - 484
EP - 490
JO - J CRANIO MAXILL SURG
JF - J CRANIO MAXILL SURG
SN - 1010-5182
IS - 3
ER -