Stability of the dexamethasone suppression test in borderline personality disorder with and without comorbid PTSD: a one-year follow-up study.
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Stability of the dexamethasone suppression test in borderline personality disorder with and without comorbid PTSD: a one-year follow-up study. / Wingenfeld, Katja; Lange, Wolfgang; Wulff, Hella; Berea, Christina; Beblo, Thomas; Saavedra, Anamaria Silva; Mensebach, Christoph; Driessen, Martin.
in: J CLIN PSYCHOL, Jahrgang 63, Nr. 9, 9, 2007, S. 843-850.Publikationen: SCORING: Beitrag in Fachzeitschrift/Zeitung › SCORING: Zeitschriftenaufsatz › Forschung › Begutachtung
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TY - JOUR
T1 - Stability of the dexamethasone suppression test in borderline personality disorder with and without comorbid PTSD: a one-year follow-up study.
AU - Wingenfeld, Katja
AU - Lange, Wolfgang
AU - Wulff, Hella
AU - Berea, Christina
AU - Beblo, Thomas
AU - Saavedra, Anamaria Silva
AU - Mensebach, Christoph
AU - Driessen, Martin
PY - 2007
Y1 - 2007
N2 - Alterations in hypothalamic-pituitary-adrenal axis feedback regulation have been repeatedly reported in patients with borderline personality disorder (BPD). Due to the cross-sectional design of these studies, little is known about the longitudinal course of HPA axis functioning. In a sample of 13 patients with BPD, the dexamethasone suppression test (DST) has been used in a one-year follow-up study. There were no changes of cortisol concentrations before or after dexamethasone intake between baseline and follow-up examination. Patients with comorbid posttraumatic stress disorder (PTSD) showed more pronounced cortisol suppression compared to those without PTSD. The DST seems to be a stable marker of alterations in HPA axis feedback regulation in BPD, which is also reflected by substantial correlations between percentage of cortisol suppression at baseline and follow-up examination.
AB - Alterations in hypothalamic-pituitary-adrenal axis feedback regulation have been repeatedly reported in patients with borderline personality disorder (BPD). Due to the cross-sectional design of these studies, little is known about the longitudinal course of HPA axis functioning. In a sample of 13 patients with BPD, the dexamethasone suppression test (DST) has been used in a one-year follow-up study. There were no changes of cortisol concentrations before or after dexamethasone intake between baseline and follow-up examination. Patients with comorbid posttraumatic stress disorder (PTSD) showed more pronounced cortisol suppression compared to those without PTSD. The DST seems to be a stable marker of alterations in HPA axis feedback regulation in BPD, which is also reflected by substantial correlations between percentage of cortisol suppression at baseline and follow-up examination.
M3 - SCORING: Zeitschriftenaufsatz
VL - 63
SP - 843
EP - 850
JO - J CLIN PSYCHOL
JF - J CLIN PSYCHOL
SN - 0021-9762
IS - 9
M1 - 9
ER -