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Specificity of Arl2/Arl3 signaling is mediated by a ternary Arl3-effector-GAP complex

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Specificity of Arl2/Arl3 signaling is mediated by a ternary Arl3-effector-GAP complex. / Veltel, Stefan; Kravchenko, Aleksandra; Ismail, Shehab; Wittinghofer, Alfred.

in: FEBS LETT, Jahrgang 582, Nr. 17, 23.07.2008, S. 2501-7.

Publikationen: SCORING: Beitrag in Fachzeitschrift/Zeitung › SCORING: Zeitschriftenaufsatz › Forschung › Begutachtung

Harvard

Veltel, S, Kravchenko, A, Ismail, S & Wittinghofer, A 2008, 'Specificity of Arl2/Arl3 signaling is mediated by a ternary Arl3-effector-GAP complex', FEBS LETT, Jg. 582, Nr. 17, S. 2501-7. https://doi.org/10.1016/j.febslet.2008.05.053

APA

Veltel, S., Kravchenko, A., Ismail, S., & Wittinghofer, A. (2008). Specificity of Arl2/Arl3 signaling is mediated by a ternary Arl3-effector-GAP complex. FEBS LETT, 582(17), 2501-7. https://doi.org/10.1016/j.febslet.2008.05.053

Vancouver

Veltel S, Kravchenko A, Ismail S, Wittinghofer A. Specificity of Arl2/Arl3 signaling is mediated by a ternary Arl3-effector-GAP complex. FEBS LETT. 2008 Jul 23;582(17):2501-7. https://doi.org/10.1016/j.febslet.2008.05.053

Bibtex

@article{2fa73e288a3441d7a4bdae2c7ba24c27,
title = "Specificity of Arl2/Arl3 signaling is mediated by a ternary Arl3-effector-GAP complex",
abstract = "Arl2 and Arl3, members of the Arf subfamily of small G proteins, are believed to be involved in ciliary and microtubule-dependent processes. Recently, we could identify RP2, responsible for a variant of X-linked retinitis pigmentosa, as the Arl3-specific GAP. Here, we have characterized Arl2/3 interactions. We show the formation of a ternary complex between Arl3, its cognate GAP RP2 and its retinal effector HRG4. This complex seems to be important for photoreceptor function.",
keywords = "ADP-Ribosylation Factors, Adaptor Proteins, Signal Transducing, Amino Acid Sequence, Cyclic Nucleotide Phosphodiesterases, Type 6, Eye Proteins, GTP-Binding Proteins, GTPase-Activating Proteins, Guanosine Diphosphate, Humans, Intracellular Signaling Peptides and Proteins, Membrane Proteins, Molecular Sequence Data, Photoreceptor Cells, Vertebrate, Protein Conformation, Signal Transduction",
author = "Stefan Veltel and Aleksandra Kravchenko and Shehab Ismail and Alfred Wittinghofer",
year = "2008",
month = jul,
day = "23",
doi = "10.1016/j.febslet.2008.05.053",
language = "English",
volume = "582",
pages = "2501--7",
journal = "FEBS LETT",
issn = "0014-5793",
publisher = "Elsevier",
number = "17",

}

RIS

TY - JOUR

T1 - Specificity of Arl2/Arl3 signaling is mediated by a ternary Arl3-effector-GAP complex

AU - Veltel, Stefan

AU - Kravchenko, Aleksandra

AU - Ismail, Shehab

AU - Wittinghofer, Alfred

PY - 2008/7/23

Y1 - 2008/7/23

N2 - Arl2 and Arl3, members of the Arf subfamily of small G proteins, are believed to be involved in ciliary and microtubule-dependent processes. Recently, we could identify RP2, responsible for a variant of X-linked retinitis pigmentosa, as the Arl3-specific GAP. Here, we have characterized Arl2/3 interactions. We show the formation of a ternary complex between Arl3, its cognate GAP RP2 and its retinal effector HRG4. This complex seems to be important for photoreceptor function.

AB - Arl2 and Arl3, members of the Arf subfamily of small G proteins, are believed to be involved in ciliary and microtubule-dependent processes. Recently, we could identify RP2, responsible for a variant of X-linked retinitis pigmentosa, as the Arl3-specific GAP. Here, we have characterized Arl2/3 interactions. We show the formation of a ternary complex between Arl3, its cognate GAP RP2 and its retinal effector HRG4. This complex seems to be important for photoreceptor function.

KW - ADP-Ribosylation Factors

KW - Adaptor Proteins, Signal Transducing

KW - Amino Acid Sequence

KW - Cyclic Nucleotide Phosphodiesterases, Type 6

KW - Eye Proteins

KW - GTP-Binding Proteins

KW - GTPase-Activating Proteins

KW - Guanosine Diphosphate

KW - Humans

KW - Intracellular Signaling Peptides and Proteins

KW - Membrane Proteins

KW - Molecular Sequence Data

KW - Photoreceptor Cells, Vertebrate

KW - Protein Conformation

KW - Signal Transduction

U2 - 10.1016/j.febslet.2008.05.053

DO - 10.1016/j.febslet.2008.05.053

M3 - SCORING: Journal article

C2 - 18588884

VL - 582

SP - 2501

EP - 2507

JO - FEBS LETT

JF - FEBS LETT

SN - 0014-5793

IS - 17

ER -