Specificity of Arl2/Arl3 signaling is mediated by a ternary Arl3-effector-GAP complex
Abstract
Arl2 and Arl3, members of the Arf subfamily of small G proteins, are believed to be involved in ciliary and microtubule-dependent processes. Recently, we could identify RP2, responsible for a variant of X-linked retinitis pigmentosa, as the Arl3-specific GAP. Here, we have characterized Arl2/3 interactions. We show the formation of a ternary complex between Arl3, its cognate GAP RP2 and its retinal effector HRG4. This complex seems to be important for photoreceptor function.
Bibliografische Daten
Originalsprache | Englisch |
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ISSN | 0014-5793 |
DOIs | |
Status | Veröffentlicht - 23.07.2008 |
Extern publiziert | Ja |
PubMed | 18588884 |
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