Sox group E gene expression distinguishes different types and maturational stages of glial cells in developing chick and mouse.

Abstract

The SoxE genes, Sox8, Sox9 and Sox10, have been shown to modulate glial specification and differentiation in the peripheral nervous system and spinal cord. However, little is known of their expression during brain development. We have therefore analyzed their expression in developing brain, focused on the cerebellum. In situ hybridization showed a striking degree of temporo-spatial variation in their expression in different glial lineages in both chick and mouse. Sox8 appeared both in oligodendrocytes and astrocytes, Sox9 was more abundant in astrocytes and Sox10 was restricted to later stages of oligodendrocyte development.

Bibliografische Daten

OriginalspracheDeutsch
Aufsatznummer2
ISSN0165-3806
StatusVeröffentlicht - 2005
pubmed 15878625