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Sonic Hedgehog promotes proliferation of Notch-dependent monociliated choroid plexus tumour cells

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Sonic Hedgehog promotes proliferation of Notch-dependent monociliated choroid plexus tumour cells. / Li, Li; Grausam, Katie B; Wang, Jun; Lun, Melody P; Ohli, Jasmin; Lidov, Hart G W; Calicchio, Monica L; Zeng, Erliang; Salisbury, Jeffrey L; Wechsler-Reya, Robert J; Lehtinen, Maria K; Schüller, Ulrich; Zhao, Haotian.

in: NAT CELL BIOL, Jahrgang 18, Nr. 4, 04.2016, S. 418-30.

Publikationen: SCORING: Beitrag in Fachzeitschrift/Zeitung › SCORING: Zeitschriftenaufsatz › Forschung › Begutachtung

Harvard

Li, L, Grausam, KB, Wang, J, Lun, MP, Ohli, J, Lidov, HGW, Calicchio, ML, Zeng, E, Salisbury, JL, Wechsler-Reya, RJ, Lehtinen, MK, Schüller, U & Zhao, H 2016, 'Sonic Hedgehog promotes proliferation of Notch-dependent monociliated choroid plexus tumour cells', NAT CELL BIOL, Jg. 18, Nr. 4, S. 418-30. https://doi.org/10.1038/ncb3327

APA

Li, L., Grausam, K. B., Wang, J., Lun, M. P., Ohli, J., Lidov, H. G. W., Calicchio, M. L., Zeng, E., Salisbury, J. L., Wechsler-Reya, R. J., Lehtinen, M. K., Schüller, U., & Zhao, H. (2016). Sonic Hedgehog promotes proliferation of Notch-dependent monociliated choroid plexus tumour cells. NAT CELL BIOL, 18(4), 418-30. https://doi.org/10.1038/ncb3327

Vancouver

Li L, Grausam KB, Wang J, Lun MP, Ohli J, Lidov HGW et al. Sonic Hedgehog promotes proliferation of Notch-dependent monociliated choroid plexus tumour cells. NAT CELL BIOL. 2016 Apr;18(4):418-30. https://doi.org/10.1038/ncb3327

Bibtex

@article{b0f2470178ef4770be9eb7319b8d470e,
title = "Sonic Hedgehog promotes proliferation of Notch-dependent monociliated choroid plexus tumour cells",
abstract = "Aberrant Notch signalling has been linked to many cancers including choroid plexus (CP) tumours, a group of rare and predominantly paediatric brain neoplasms. We developed animal models of CP tumours, by inducing sustained expression of Notch1, that recapitulate properties of human CP tumours with aberrant NOTCH signalling. Whole-transcriptome and functional analyses showed that tumour cell proliferation is associated with Sonic Hedgehog (Shh) in the tumour microenvironment. Unlike CP epithelial cells, which have multiple primary cilia, tumour cells possess a solitary primary cilium as a result of Notch-mediated suppression of multiciliate differentiation. A Shh-driven signalling cascade in the primary cilium occurs in tumour cells but not in epithelial cells. Lineage studies show that CP tumours arise from monociliated progenitors in the roof plate characterized by elevated Notch signalling. Abnormal SHH signalling and distinct ciliogenesis are detected in human CP tumours, suggesting the SHH pathway and cilia differentiation as potential therapeutic avenues.",
keywords = "Animals, Blotting, Western, Cell Proliferation, Choroid Plexus, Choroid Plexus Neoplasms, Cilia, Female, Gene Expression Profiling, Gene Expression Regulation, Neoplastic, Hedgehog Proteins, Humans, Male, Mice, 129 Strain, Mice, Inbred C57BL, Mice, Transgenic, Microscopy, Confocal, Microscopy, Electron, Transmission, Oligonucleotide Array Sequence Analysis, Receptor, Notch1, Reverse Transcriptase Polymerase Chain Reaction, Signal Transduction, Tumor Cells, Cultured, Tumor Microenvironment, Journal Article, Research Support, N.I.H., Extramural, Research Support, Non-U.S. Gov't",
author = "Li Li and Grausam, {Katie B} and Jun Wang and Lun, {Melody P} and Jasmin Ohli and Lidov, {Hart G W} and Calicchio, {Monica L} and Erliang Zeng and Salisbury, {Jeffrey L} and Wechsler-Reya, {Robert J} and Lehtinen, {Maria K} and Ulrich Sch{\"u}ller and Haotian Zhao",
year = "2016",
month = apr,
doi = "10.1038/ncb3327",
language = "English",
volume = "18",
pages = "418--30",
journal = "NAT CELL BIOL",
issn = "1465-7392",
publisher = "NATURE PUBLISHING GROUP",
number = "4",

}

RIS

TY - JOUR

T1 - Sonic Hedgehog promotes proliferation of Notch-dependent monociliated choroid plexus tumour cells

AU - Li, Li

AU - Grausam, Katie B

AU - Wang, Jun

AU - Lun, Melody P

AU - Ohli, Jasmin

AU - Lidov, Hart G W

AU - Calicchio, Monica L

AU - Zeng, Erliang

AU - Salisbury, Jeffrey L

AU - Wechsler-Reya, Robert J

AU - Lehtinen, Maria K

AU - Schüller, Ulrich

AU - Zhao, Haotian

PY - 2016/4

Y1 - 2016/4

N2 - Aberrant Notch signalling has been linked to many cancers including choroid plexus (CP) tumours, a group of rare and predominantly paediatric brain neoplasms. We developed animal models of CP tumours, by inducing sustained expression of Notch1, that recapitulate properties of human CP tumours with aberrant NOTCH signalling. Whole-transcriptome and functional analyses showed that tumour cell proliferation is associated with Sonic Hedgehog (Shh) in the tumour microenvironment. Unlike CP epithelial cells, which have multiple primary cilia, tumour cells possess a solitary primary cilium as a result of Notch-mediated suppression of multiciliate differentiation. A Shh-driven signalling cascade in the primary cilium occurs in tumour cells but not in epithelial cells. Lineage studies show that CP tumours arise from monociliated progenitors in the roof plate characterized by elevated Notch signalling. Abnormal SHH signalling and distinct ciliogenesis are detected in human CP tumours, suggesting the SHH pathway and cilia differentiation as potential therapeutic avenues.

AB - Aberrant Notch signalling has been linked to many cancers including choroid plexus (CP) tumours, a group of rare and predominantly paediatric brain neoplasms. We developed animal models of CP tumours, by inducing sustained expression of Notch1, that recapitulate properties of human CP tumours with aberrant NOTCH signalling. Whole-transcriptome and functional analyses showed that tumour cell proliferation is associated with Sonic Hedgehog (Shh) in the tumour microenvironment. Unlike CP epithelial cells, which have multiple primary cilia, tumour cells possess a solitary primary cilium as a result of Notch-mediated suppression of multiciliate differentiation. A Shh-driven signalling cascade in the primary cilium occurs in tumour cells but not in epithelial cells. Lineage studies show that CP tumours arise from monociliated progenitors in the roof plate characterized by elevated Notch signalling. Abnormal SHH signalling and distinct ciliogenesis are detected in human CP tumours, suggesting the SHH pathway and cilia differentiation as potential therapeutic avenues.

KW - Animals

KW - Blotting, Western

KW - Cell Proliferation

KW - Choroid Plexus

KW - Choroid Plexus Neoplasms

KW - Cilia

KW - Female

KW - Gene Expression Profiling

KW - Gene Expression Regulation, Neoplastic

KW - Hedgehog Proteins

KW - Humans

KW - Male

KW - Mice, 129 Strain

KW - Mice, Inbred C57BL

KW - Mice, Transgenic

KW - Microscopy, Confocal

KW - Microscopy, Electron, Transmission

KW - Oligonucleotide Array Sequence Analysis

KW - Receptor, Notch1

KW - Reverse Transcriptase Polymerase Chain Reaction

KW - Signal Transduction

KW - Tumor Cells, Cultured

KW - Tumor Microenvironment

KW - Journal Article

KW - Research Support, N.I.H., Extramural

KW - Research Support, Non-U.S. Gov't

U2 - 10.1038/ncb3327

DO - 10.1038/ncb3327

M3 - SCORING: Journal article

C2 - 26999738

VL - 18

SP - 418

EP - 430

JO - NAT CELL BIOL

JF - NAT CELL BIOL

SN - 1465-7392

IS - 4

ER -