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Solid-state NMR spectroscopy applied to a chimeric potassium channel in lipid bilayers.

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Solid-state NMR spectroscopy applied to a chimeric potassium channel in lipid bilayers. / Schneider, Robert; Ader, Christian; Lange, Adam; Giller, Karin; Hornig, Sönke; Pongs, Olaf; Becker, Stefan; Baldus, Marc.

in: J AM CHEM SOC, Jahrgang 130, Nr. 23, 23, 2008, S. 7427-7435.

Publikationen: SCORING: Beitrag in Fachzeitschrift/Zeitung › SCORING: Zeitschriftenaufsatz › Forschung › Begutachtung

Harvard

Schneider, R, Ader, C, Lange, A, Giller, K, Hornig, S, Pongs, O, Becker, S & Baldus, M 2008, 'Solid-state NMR spectroscopy applied to a chimeric potassium channel in lipid bilayers.', J AM CHEM SOC, Jg. 130, Nr. 23, 23, S. 7427-7435. <http://www.ncbi.nlm.nih.gov/pubmed/18479093?dopt=Citation>

APA

Schneider, R., Ader, C., Lange, A., Giller, K., Hornig, S., Pongs, O., Becker, S., & Baldus, M. (2008). Solid-state NMR spectroscopy applied to a chimeric potassium channel in lipid bilayers. J AM CHEM SOC, 130(23), 7427-7435. [23]. http://www.ncbi.nlm.nih.gov/pubmed/18479093?dopt=Citation

Vancouver

Schneider R, Ader C, Lange A, Giller K, Hornig S, Pongs O et al. Solid-state NMR spectroscopy applied to a chimeric potassium channel in lipid bilayers. J AM CHEM SOC. 2008;130(23):7427-7435. 23.

Bibtex

@article{0e56b340abb742f086680529844b56c5,
title = "Solid-state NMR spectroscopy applied to a chimeric potassium channel in lipid bilayers.",
abstract = "We show that solid-state NMR can be used to investigate the structure and dynamics of a chimeric potassium channel, KcsA-Kv1.3, in lipid bilayers. Sequential resonance assignments were obtained using a combination of (15)N- (13)C and (13)C- (13)C correlation experiments conducted on fully labeled and reverse-labeled as well as C-terminally truncated samples. Comparison of our results with those from X-ray crystallography and solution-state NMR in micelles on the closely related KcsA K (+) channel provides insight into the mechanism of ion channel selectivity and underlines the important role of the lipid environment for membrane protein structure and function.",
author = "Robert Schneider and Christian Ader and Adam Lange and Karin Giller and S{\"o}nke Hornig and Olaf Pongs and Stefan Becker and Marc Baldus",
year = "2008",
language = "Deutsch",
volume = "130",
pages = "7427--7435",
journal = "J AM CHEM SOC",
issn = "0002-7863",
publisher = "American Chemical Society",
number = "23",

}

RIS

TY - JOUR

T1 - Solid-state NMR spectroscopy applied to a chimeric potassium channel in lipid bilayers.

AU - Schneider, Robert

AU - Ader, Christian

AU - Lange, Adam

AU - Giller, Karin

AU - Hornig, Sönke

AU - Pongs, Olaf

AU - Becker, Stefan

AU - Baldus, Marc

PY - 2008

Y1 - 2008

N2 - We show that solid-state NMR can be used to investigate the structure and dynamics of a chimeric potassium channel, KcsA-Kv1.3, in lipid bilayers. Sequential resonance assignments were obtained using a combination of (15)N- (13)C and (13)C- (13)C correlation experiments conducted on fully labeled and reverse-labeled as well as C-terminally truncated samples. Comparison of our results with those from X-ray crystallography and solution-state NMR in micelles on the closely related KcsA K (+) channel provides insight into the mechanism of ion channel selectivity and underlines the important role of the lipid environment for membrane protein structure and function.

AB - We show that solid-state NMR can be used to investigate the structure and dynamics of a chimeric potassium channel, KcsA-Kv1.3, in lipid bilayers. Sequential resonance assignments were obtained using a combination of (15)N- (13)C and (13)C- (13)C correlation experiments conducted on fully labeled and reverse-labeled as well as C-terminally truncated samples. Comparison of our results with those from X-ray crystallography and solution-state NMR in micelles on the closely related KcsA K (+) channel provides insight into the mechanism of ion channel selectivity and underlines the important role of the lipid environment for membrane protein structure and function.

M3 - SCORING: Zeitschriftenaufsatz

VL - 130

SP - 7427

EP - 7435

JO - J AM CHEM SOC

JF - J AM CHEM SOC

SN - 0002-7863

IS - 23

M1 - 23

ER -