Single gold nanorods as optical probes for spectral imaging
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Single gold nanorods as optical probes for spectral imaging. / Wackenhut, Frank; Failla, Antonio Virgilio; Meixner, Alfred J.
in: ANAL BIOANAL CHEM, Jahrgang 407, Nr. 14, 05.2015, S. 4029-4034.Publikationen: SCORING: Beitrag in Fachzeitschrift/Zeitung › SCORING: Zeitschriftenaufsatz › Forschung › Begutachtung
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TY - JOUR
T1 - Single gold nanorods as optical probes for spectral imaging
AU - Wackenhut, Frank
AU - Failla, Antonio Virgilio
AU - Meixner, Alfred J
PY - 2015/5
Y1 - 2015/5
N2 - In this paper, we explain in detail the wavelength dependence of the elastic scattering pattern of individual, optically isolated gold nanorods by using confocal microscopy in combination with higher order laser modes, i.e., radially/azimuthally polarized laser modes. We demonstrate that the spectral dependence of the scattering pattern is mostly caused by the relative strength of the gold nanorods' plasmonic modes at different wavelengths. Since the gold nanorods' plasmonic modes are determined by the particles' geometrical parameter, e.g., size and aspect ratio, as well as the refractive index of the surrounding medium, we show that the spectral dependence of the scattering pattern is a simple, not invasive way to determine, e.g., the gold nanorod aspect ratio or physical variation of the local environment. Thus, a further development of spectral imaging of gold nanorods can lead to the employment of this technique in biomedical assays involving also living samples.
AB - In this paper, we explain in detail the wavelength dependence of the elastic scattering pattern of individual, optically isolated gold nanorods by using confocal microscopy in combination with higher order laser modes, i.e., radially/azimuthally polarized laser modes. We demonstrate that the spectral dependence of the scattering pattern is mostly caused by the relative strength of the gold nanorods' plasmonic modes at different wavelengths. Since the gold nanorods' plasmonic modes are determined by the particles' geometrical parameter, e.g., size and aspect ratio, as well as the refractive index of the surrounding medium, we show that the spectral dependence of the scattering pattern is a simple, not invasive way to determine, e.g., the gold nanorod aspect ratio or physical variation of the local environment. Thus, a further development of spectral imaging of gold nanorods can lead to the employment of this technique in biomedical assays involving also living samples.
KW - Biosensing Techniques
KW - Gold
KW - Metal Nanoparticles
KW - Microscopy, Confocal
KW - Spectrum Analysis
KW - Staining and Labeling
KW - Journal Article
KW - Research Support, Non-U.S. Gov't
U2 - 10.1007/s00216-015-8642-1
DO - 10.1007/s00216-015-8642-1
M3 - SCORING: Journal article
C2 - 25855152
VL - 407
SP - 4029
EP - 4034
JO - ANAL BIOANAL CHEM
JF - ANAL BIOANAL CHEM
SN - 1618-2642
IS - 14
ER -