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Sex-specific epigenetic gene activation profiles are differentially modulated in human placentas affected by intrauterine growth restriction

Standard

Sex-specific epigenetic gene activation profiles are differentially modulated in human placentas affected by intrauterine growth restriction. / Meister, Sarah; Kolben, Thomas; Beyer, Susanne; Hutter, Stefan; Hofmann, Simone; Kuhn, Christina; Messner, Julia; Mayr, Doris; Solano, Maria Emilia; Jegen, Magdalena; Obermeier, Viola; Mahner, Sven; Arck, Petra; Jeschke, Udo.

in: J REPROD IMMUNOL, Nr. 139, 06.2020, S. 103124.

Publikationen: SCORING: Beitrag in Fachzeitschrift/Zeitung › SCORING: Zeitschriftenaufsatz › Forschung › Begutachtung

Harvard

Meister, S, Kolben, T, Beyer, S, Hutter, S, Hofmann, S, Kuhn, C, Messner, J, Mayr, D, Solano, ME, Jegen, M, Obermeier, V, Mahner, S, Arck, P & Jeschke, U 2020, 'Sex-specific epigenetic gene activation profiles are differentially modulated in human placentas affected by intrauterine growth restriction', J REPROD IMMUNOL, Nr. 139, S. 103124. https://doi.org/10.1016/j.jri.2020.103124

APA

Meister, S., Kolben, T., Beyer, S., Hutter, S., Hofmann, S., Kuhn, C., Messner, J., Mayr, D., Solano, M. E., Jegen, M., Obermeier, V., Mahner, S., Arck, P., & Jeschke, U. (2020). Sex-specific epigenetic gene activation profiles are differentially modulated in human placentas affected by intrauterine growth restriction. J REPROD IMMUNOL, (139), 103124. https://doi.org/10.1016/j.jri.2020.103124

Vancouver

Meister S, Kolben T, Beyer S, Hutter S, Hofmann S, Kuhn C et al. Sex-specific epigenetic gene activation profiles are differentially modulated in human placentas affected by intrauterine growth restriction. J REPROD IMMUNOL. 2020 Jun;(139):103124. https://doi.org/10.1016/j.jri.2020.103124

Bibtex

@article{07082d3c5c2b4a08b88da7f5daecdee2,
title = "Sex-specific epigenetic gene activation profiles are differentially modulated in human placentas affected by intrauterine growth restriction",
abstract = "BACKGROUND: The purpose of this study was to investigate the sex specific expression of histone protein modifications responsible for rapid gene expression in IUGR placentas.PATIENTS AND METHODS: We screened for fetal sex-specific expression of the histone proteins H3K4me3 and H3K9ac in 23 IUGR and 40 control placentas via immunohistochemistry. The trophoblast-like cell line BeWo was used in order to analyze a potential effect of stimulation with prednisolone on H3K4me3 and H3K9ac in vitro. Calculating regression models with additional adjustment for potential confounders were used.RESULTS: A significantly decreased level of H3K4me3 was detectable in female syncytiotrophoblasts, whereas H3K9ac was reduced predominantly in male extravillous throphoblast (EVT). No association to the gestational age existed.CONCLUSION: Our data showed a reduced expression of the histone proteins H3K4me3 (female) and H3K9ac (male) in IUGR, furthermore elevated cortisol levels may lead to a sex-specific down-regulation of histone proteins in IUGR placentas.",
author = "Sarah Meister and Thomas Kolben and Susanne Beyer and Stefan Hutter and Simone Hofmann and Christina Kuhn and Julia Messner and Doris Mayr and Solano, {Maria Emilia} and Magdalena Jegen and Viola Obermeier and Sven Mahner and Petra Arck and Udo Jeschke",
note = "Copyright {\textcopyright} 2020 Elsevier B.V. All rights reserved.",
year = "2020",
month = jun,
doi = "10.1016/j.jri.2020.103124",
language = "English",
pages = "103124",
journal = "J REPROD IMMUNOL",
issn = "0165-0378",
publisher = "Elsevier Ireland Ltd",
number = "139",

}

RIS

TY - JOUR

T1 - Sex-specific epigenetic gene activation profiles are differentially modulated in human placentas affected by intrauterine growth restriction

AU - Meister, Sarah

AU - Kolben, Thomas

AU - Beyer, Susanne

AU - Hutter, Stefan

AU - Hofmann, Simone

AU - Kuhn, Christina

AU - Messner, Julia

AU - Mayr, Doris

AU - Solano, Maria Emilia

AU - Jegen, Magdalena

AU - Obermeier, Viola

AU - Mahner, Sven

AU - Arck, Petra

AU - Jeschke, Udo

N1 - Copyright © 2020 Elsevier B.V. All rights reserved.

PY - 2020/6

Y1 - 2020/6

N2 - BACKGROUND: The purpose of this study was to investigate the sex specific expression of histone protein modifications responsible for rapid gene expression in IUGR placentas.PATIENTS AND METHODS: We screened for fetal sex-specific expression of the histone proteins H3K4me3 and H3K9ac in 23 IUGR and 40 control placentas via immunohistochemistry. The trophoblast-like cell line BeWo was used in order to analyze a potential effect of stimulation with prednisolone on H3K4me3 and H3K9ac in vitro. Calculating regression models with additional adjustment for potential confounders were used.RESULTS: A significantly decreased level of H3K4me3 was detectable in female syncytiotrophoblasts, whereas H3K9ac was reduced predominantly in male extravillous throphoblast (EVT). No association to the gestational age existed.CONCLUSION: Our data showed a reduced expression of the histone proteins H3K4me3 (female) and H3K9ac (male) in IUGR, furthermore elevated cortisol levels may lead to a sex-specific down-regulation of histone proteins in IUGR placentas.

AB - BACKGROUND: The purpose of this study was to investigate the sex specific expression of histone protein modifications responsible for rapid gene expression in IUGR placentas.PATIENTS AND METHODS: We screened for fetal sex-specific expression of the histone proteins H3K4me3 and H3K9ac in 23 IUGR and 40 control placentas via immunohistochemistry. The trophoblast-like cell line BeWo was used in order to analyze a potential effect of stimulation with prednisolone on H3K4me3 and H3K9ac in vitro. Calculating regression models with additional adjustment for potential confounders were used.RESULTS: A significantly decreased level of H3K4me3 was detectable in female syncytiotrophoblasts, whereas H3K9ac was reduced predominantly in male extravillous throphoblast (EVT). No association to the gestational age existed.CONCLUSION: Our data showed a reduced expression of the histone proteins H3K4me3 (female) and H3K9ac (male) in IUGR, furthermore elevated cortisol levels may lead to a sex-specific down-regulation of histone proteins in IUGR placentas.

U2 - 10.1016/j.jri.2020.103124

DO - 10.1016/j.jri.2020.103124

M3 - SCORING: Journal article

C2 - 32289580

SP - 103124

JO - J REPROD IMMUNOL

JF - J REPROD IMMUNOL

SN - 0165-0378

IS - 139

ER -