Semiquantitative aspects of mast cells in normal skin and in neurofibromas of neurofibromatosis types 1 and 5.
Standard
Semiquantitative aspects of mast cells in normal skin and in neurofibromas of neurofibromatosis types 1 and 5. / Nürnberger, M; Moll, Ingrid.
in: DERMATOLOGY, Jahrgang 188, Nr. 4, 4, 1994, S. 296-299.Publikationen: SCORING: Beitrag in Fachzeitschrift/Zeitung › SCORING: Zeitschriftenaufsatz › Forschung › Begutachtung
Harvard
APA
Vancouver
Bibtex
}
RIS
TY - JOUR
T1 - Semiquantitative aspects of mast cells in normal skin and in neurofibromas of neurofibromatosis types 1 and 5.
AU - Nürnberger, M
AU - Moll, Ingrid
PY - 1994
Y1 - 1994
N2 - Mast cells are supported to influence the growth of neurofibromas, because some of their mediators may also act as growth factors. Accordingly, mast cell stabilizers are claimed to reduce proliferation and itching of neurofibromas. Therefore, we quantified the mast cells of 19 neurofibromas and compared them with normal skin. We saw a statistically significant increase in mast cells in neurofibromas versus normal skin. However, there is no correlation between the age of neurofibromatosis (NF) patients and mast cell density. In our study the density of mast cells in neurofibromas is also independent of NF type; age of neurofibroma and chronic ultraviolet exposure in contrast to normal skin. Different tumors of the same patient had similar mast cell counts.
AB - Mast cells are supported to influence the growth of neurofibromas, because some of their mediators may also act as growth factors. Accordingly, mast cell stabilizers are claimed to reduce proliferation and itching of neurofibromas. Therefore, we quantified the mast cells of 19 neurofibromas and compared them with normal skin. We saw a statistically significant increase in mast cells in neurofibromas versus normal skin. However, there is no correlation between the age of neurofibromatosis (NF) patients and mast cell density. In our study the density of mast cells in neurofibromas is also independent of NF type; age of neurofibroma and chronic ultraviolet exposure in contrast to normal skin. Different tumors of the same patient had similar mast cell counts.
M3 - SCORING: Zeitschriftenaufsatz
VL - 188
SP - 296
EP - 299
JO - DERMATOLOGY
JF - DERMATOLOGY
SN - 1018-8665
IS - 4
M1 - 4
ER -