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Scleral Inflammation around Collector Channels in Eyes with Primary Open-Angle Glaucoma

Standard

Scleral Inflammation around Collector Channels in Eyes with Primary Open-Angle Glaucoma. / Schultheiss, Maximilian; Voykov, Bogomil; Klemm, Maren; Gross, Ulrich; Schultheiss, Heinz-Peter; Spitzer, Martin S; Casagrande, Maria.

in: OCUL IMMUNOL INFLAMM, 2020, S. 1-7.

Publikationen: SCORING: Beitrag in Fachzeitschrift/Zeitung › SCORING: Zeitschriftenaufsatz › Forschung › Begutachtung

Harvard

Schultheiss, M, Voykov, B, Klemm, M, Gross, U, Schultheiss, H-P, Spitzer, MS & Casagrande, M 2020, 'Scleral Inflammation around Collector Channels in Eyes with Primary Open-Angle Glaucoma', OCUL IMMUNOL INFLAMM, S. 1-7. https://doi.org/10.1080/09273948.2020.1746355

APA

Schultheiss, M., Voykov, B., Klemm, M., Gross, U., Schultheiss, H-P., Spitzer, M. S., & Casagrande, M. (2020). Scleral Inflammation around Collector Channels in Eyes with Primary Open-Angle Glaucoma. OCUL IMMUNOL INFLAMM, 1-7. https://doi.org/10.1080/09273948.2020.1746355

Vancouver

Schultheiss M, Voykov B, Klemm M, Gross U, Schultheiss H-P, Spitzer MS et al. Scleral Inflammation around Collector Channels in Eyes with Primary Open-Angle Glaucoma. OCUL IMMUNOL INFLAMM. 2020;1-7. https://doi.org/10.1080/09273948.2020.1746355

Bibtex

@article{ada7a3e509884c0395b12244ed8b5e49,
title = "Scleral Inflammation around Collector Channels in Eyes with Primary Open-Angle Glaucoma",
abstract = "Purpose: Investigating the existence of inflammation in the distal outflow system posterior of the Schlemm's canal in primary open-angle glaucoma (POAG).Methods: Scleral biopsies (n = 62) from POAG-patients were taken during deep sclerectomy and fixed either in formalin or RNAlater{\textregistered}. Histologic (hematoxylin & eosin) and immunohistological staining for CD 3 and CD 45RO were performed.Results: Cellular infiltration of immunocompetent cells (CD 3 and CD 45RO positive cells) exists around collector channels (CC). This inflammation is limited to the area around the CCs. Ninety-two percent of the biopsies are positive for inflammation. Untreated, dysgenetic glaucoma eyes and 8% of POAG eyes were negative for inflammation. Neither the use of benzalkonium chloride nor the number and type of preoperative antiglaucomatous medication correlated to the immunohistological result.Conclusion: In POAG a diverse cellular infiltration exists around the CCs in the vast majority of biopsies. This could have major diagnostic and therapeutic consequences for the treatment of POAG.Abbreviations: POAG: primary open-angle glaucoma; CC: collector channel; AH: aqueous humor; TM: trabecular meshwork; SC: Schlemm's canal; HE: hematoxylin & eosin; APC: antigen-presenting cell.",
author = "Maximilian Schultheiss and Bogomil Voykov and Maren Klemm and Ulrich Gross and Heinz-Peter Schultheiss and Spitzer, {Martin S} and Maria Casagrande",
year = "2020",
doi = "10.1080/09273948.2020.1746355",
language = "English",
pages = "1--7",
journal = "OCUL IMMUNOL INFLAMM",
issn = "0927-3948",
publisher = "informa healthcare",

}

RIS

TY - JOUR

T1 - Scleral Inflammation around Collector Channels in Eyes with Primary Open-Angle Glaucoma

AU - Schultheiss, Maximilian

AU - Voykov, Bogomil

AU - Klemm, Maren

AU - Gross, Ulrich

AU - Schultheiss, Heinz-Peter

AU - Spitzer, Martin S

AU - Casagrande, Maria

PY - 2020

Y1 - 2020

N2 - Purpose: Investigating the existence of inflammation in the distal outflow system posterior of the Schlemm's canal in primary open-angle glaucoma (POAG).Methods: Scleral biopsies (n = 62) from POAG-patients were taken during deep sclerectomy and fixed either in formalin or RNAlater®. Histologic (hematoxylin & eosin) and immunohistological staining for CD 3 and CD 45RO were performed.Results: Cellular infiltration of immunocompetent cells (CD 3 and CD 45RO positive cells) exists around collector channels (CC). This inflammation is limited to the area around the CCs. Ninety-two percent of the biopsies are positive for inflammation. Untreated, dysgenetic glaucoma eyes and 8% of POAG eyes were negative for inflammation. Neither the use of benzalkonium chloride nor the number and type of preoperative antiglaucomatous medication correlated to the immunohistological result.Conclusion: In POAG a diverse cellular infiltration exists around the CCs in the vast majority of biopsies. This could have major diagnostic and therapeutic consequences for the treatment of POAG.Abbreviations: POAG: primary open-angle glaucoma; CC: collector channel; AH: aqueous humor; TM: trabecular meshwork; SC: Schlemm's canal; HE: hematoxylin & eosin; APC: antigen-presenting cell.

AB - Purpose: Investigating the existence of inflammation in the distal outflow system posterior of the Schlemm's canal in primary open-angle glaucoma (POAG).Methods: Scleral biopsies (n = 62) from POAG-patients were taken during deep sclerectomy and fixed either in formalin or RNAlater®. Histologic (hematoxylin & eosin) and immunohistological staining for CD 3 and CD 45RO were performed.Results: Cellular infiltration of immunocompetent cells (CD 3 and CD 45RO positive cells) exists around collector channels (CC). This inflammation is limited to the area around the CCs. Ninety-two percent of the biopsies are positive for inflammation. Untreated, dysgenetic glaucoma eyes and 8% of POAG eyes were negative for inflammation. Neither the use of benzalkonium chloride nor the number and type of preoperative antiglaucomatous medication correlated to the immunohistological result.Conclusion: In POAG a diverse cellular infiltration exists around the CCs in the vast majority of biopsies. This could have major diagnostic and therapeutic consequences for the treatment of POAG.Abbreviations: POAG: primary open-angle glaucoma; CC: collector channel; AH: aqueous humor; TM: trabecular meshwork; SC: Schlemm's canal; HE: hematoxylin & eosin; APC: antigen-presenting cell.

U2 - 10.1080/09273948.2020.1746355

DO - 10.1080/09273948.2020.1746355

M3 - SCORING: Journal article

C2 - 32400241

SP - 1

EP - 7

JO - OCUL IMMUNOL INFLAMM

JF - OCUL IMMUNOL INFLAMM

SN - 0927-3948

ER -