Safety of optical coherence tomography in pediatric heart transplant patients
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Safety of optical coherence tomography in pediatric heart transplant patients. / Ulrich, Sarah M; Lehner, Anja; Birnbaum, Julia; Heckel, Stefanie; Haas, Nikolaus A; Hakami, Lale; Schramm, Rene; Dalla Pozza, Robert; Fischer, Marcus; Kozlik-Feldmann, Rainer.
in: INT J CARDIOL, Jahrgang 228, 01.02.2017, S. 205-208.Publikationen: SCORING: Beitrag in Fachzeitschrift/Zeitung › SCORING: Zeitschriftenaufsatz › Forschung › Begutachtung
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TY - JOUR
T1 - Safety of optical coherence tomography in pediatric heart transplant patients
AU - Ulrich, Sarah M
AU - Lehner, Anja
AU - Birnbaum, Julia
AU - Heckel, Stefanie
AU - Haas, Nikolaus A
AU - Hakami, Lale
AU - Schramm, Rene
AU - Dalla Pozza, Robert
AU - Fischer, Marcus
AU - Kozlik-Feldmann, Rainer
N1 - Copyright © 2016 Elsevier Ireland Ltd. All rights reserved.
PY - 2017/2/1
Y1 - 2017/2/1
N2 - BACKGROUND: Cardiac allograft vasculopathy (CAV) is a crucial problem after heart transplantation, in adults as well as in children. CAV is the main risk factor for a reduced long-term graft survival. The early diagnosis and treatment of CAV is essential for a successful long-term preservation of the donor heart. However, asymptomatic progression of CAV and concentric hyperplasia of the coronary arteries may complicate the early diagnosis by conventional measures. Intravascular imaging, such as intravascular ultrasound and optical coherence tomography (OCT), enables the diagnosis of early stage CAV. To date, there is little known about OCT in children. We present our single center experience with OCT after pediatric heart transplantation.METHODS: Retrospective analysis of OCT (n=50) after pediatric heart transplantation between June 2013 and March 2016 and comparison between angiographic appearance and OCT.RESULTS: 37 patients underwent optical coherence tomography, nine patients were examined twice and two patients tree times. The youngest patient at time of examination was 4years with a weight of 15kg (mean 50.86kg, range 15 to 88kg). There were no complications, especially no bleeding, no arrhythmias or myocardial ischemic events. Early CAV (Stanford I or II) was detected by OCT in 26 cases. Only in four of these cases, also the coronary angiography showed mild changes.CONCLUSION: OCT is a safe intravascular imaging method that can also be used in children after pediatric heart transplantation up to a minimum weight of 15kg without an increasing risk of a catheterization procedure.
AB - BACKGROUND: Cardiac allograft vasculopathy (CAV) is a crucial problem after heart transplantation, in adults as well as in children. CAV is the main risk factor for a reduced long-term graft survival. The early diagnosis and treatment of CAV is essential for a successful long-term preservation of the donor heart. However, asymptomatic progression of CAV and concentric hyperplasia of the coronary arteries may complicate the early diagnosis by conventional measures. Intravascular imaging, such as intravascular ultrasound and optical coherence tomography (OCT), enables the diagnosis of early stage CAV. To date, there is little known about OCT in children. We present our single center experience with OCT after pediatric heart transplantation.METHODS: Retrospective analysis of OCT (n=50) after pediatric heart transplantation between June 2013 and March 2016 and comparison between angiographic appearance and OCT.RESULTS: 37 patients underwent optical coherence tomography, nine patients were examined twice and two patients tree times. The youngest patient at time of examination was 4years with a weight of 15kg (mean 50.86kg, range 15 to 88kg). There were no complications, especially no bleeding, no arrhythmias or myocardial ischemic events. Early CAV (Stanford I or II) was detected by OCT in 26 cases. Only in four of these cases, also the coronary angiography showed mild changes.CONCLUSION: OCT is a safe intravascular imaging method that can also be used in children after pediatric heart transplantation up to a minimum weight of 15kg without an increasing risk of a catheterization procedure.
KW - Adolescent
KW - Cardiac Catheterization
KW - Child
KW - Child, Preschool
KW - Coronary Angiography
KW - Coronary Artery Disease/diagnostic imaging
KW - Female
KW - Heart Failure/diagnostic imaging
KW - Heart Transplantation/adverse effects
KW - Humans
KW - Infant
KW - Infant, Newborn
KW - Male
KW - Postoperative Complications/diagnostic imaging
KW - Retrospective Studies
KW - Tomography, Optical Coherence
U2 - 10.1016/j.ijcard.2016.11.109
DO - 10.1016/j.ijcard.2016.11.109
M3 - SCORING: Journal article
C2 - 27866017
VL - 228
SP - 205
EP - 208
JO - INT J CARDIOL
JF - INT J CARDIOL
SN - 0167-5273
ER -