Role of mTOR Signaling for Tubular Function and Disease

Beteiligte Einrichtungen

Abstract

The mechanistic target of rapamycin (mTOR) forms two distinct intracellular multiprotein complexes that control a multitude of intracellular processes linked to metabolism, proliferation, actin cytoskeleton, and survival. Recent studies have identified the importance of these complexes for transport regulation of ions and nutrients along the entire nephron. First reports could link altered activity of these complexes to certain disease entities, i.e. diabetic nephropathy, acute kidney injury or hyperkalemia.

Bibliografische Daten

OriginalspracheEnglisch
ISSN1548-9213
DOIs
StatusVeröffentlicht - 01.11.2021
PubMed 34514872