Role of L1CAM in the Regulation of the Canonical Wnt Pathway and Class I MAGE Genes
Standard
Role of L1CAM in the Regulation of the Canonical Wnt Pathway and Class I MAGE Genes. / Shkurnikov, M Yu; Knyazev, E N; Wicklein, D; Schumacher, U; Samatov, T R; Tonevitsky, A G.
in: B EXP BIOL MED+, Jahrgang 160, Nr. 6, 04.2016, S. 807-10.Publikationen: SCORING: Beitrag in Fachzeitschrift/Zeitung › SCORING: Zeitschriftenaufsatz › Forschung › Begutachtung
Harvard
APA
Vancouver
Bibtex
}
RIS
TY - JOUR
T1 - Role of L1CAM in the Regulation of the Canonical Wnt Pathway and Class I MAGE Genes
AU - Shkurnikov, M Yu
AU - Knyazev, E N
AU - Wicklein, D
AU - Schumacher, U
AU - Samatov, T R
AU - Tonevitsky, A G
PY - 2016/4
Y1 - 2016/4
N2 - Molecule L1CAM is specific for nerve cells and tumors of various localizations. The expression of L1CAM is significantly higher in melanoma in comparison with benign nevi and correlates with the progress of melanoma and transition from radial to vertical growth. Monoclonal antibodies to L1CAM effectively and specifically attenuate melanoma growth, though stimulates the epithelial-mesenchymal transition. shRNA-mediated knock-down of L1CAM showed the involvement of L1CAM in regulation of activity of the canonical Wnt pathway and expression of genes of class I melanoma-associated antigens (MAGE).
AB - Molecule L1CAM is specific for nerve cells and tumors of various localizations. The expression of L1CAM is significantly higher in melanoma in comparison with benign nevi and correlates with the progress of melanoma and transition from radial to vertical growth. Monoclonal antibodies to L1CAM effectively and specifically attenuate melanoma growth, though stimulates the epithelial-mesenchymal transition. shRNA-mediated knock-down of L1CAM showed the involvement of L1CAM in regulation of activity of the canonical Wnt pathway and expression of genes of class I melanoma-associated antigens (MAGE).
U2 - 10.1007/s10517-016-3315-4
DO - 10.1007/s10517-016-3315-4
M3 - SCORING: Journal article
C2 - 27165065
VL - 160
SP - 807
EP - 810
JO - B EXP BIOL MED+
JF - B EXP BIOL MED+
SN - 0007-4888
IS - 6
ER -