Role of IGFBP6 Protein in the Regulation of Epithelial-Mesenchymal Transition Genes
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Role of IGFBP6 Protein in the Regulation of Epithelial-Mesenchymal Transition Genes. / Nikulin, S V; Raigorodskaya, M P; Poloznikov, A A; Zakharova, G S; Schumacher, U; Wicklein, D; Stürken, C; Riecken, K; Fomicheva, K A; Alekseev, B Ya; Shkurnikov, M Yu.
in: B EXP BIOL MED+, Jahrgang 164, Nr. 5, 03.2018, S. 650-654.Publikationen: SCORING: Beitrag in Fachzeitschrift/Zeitung › SCORING: Zeitschriftenaufsatz › Forschung › Begutachtung
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TY - JOUR
T1 - Role of IGFBP6 Protein in the Regulation of Epithelial-Mesenchymal Transition Genes
AU - Nikulin, S V
AU - Raigorodskaya, M P
AU - Poloznikov, A A
AU - Zakharova, G S
AU - Schumacher, U
AU - Wicklein, D
AU - Stürken, C
AU - Riecken, K
AU - Fomicheva, K A
AU - Alekseev, B Ya
AU - Shkurnikov, M Yu
PY - 2018/3
Y1 - 2018/3
N2 - Protein IGFBP6 plays an important role in the pathogenesis of many malignant tumors, including breast cancer. The relationship between IGFBP6 protein and the expression of genes associated with the epithelial-mesenchymal transition is studied. Gene IGFBP6 knockdown does not trigger the epithelial-mesenchymal transition in MDA-MB-231 cells, but modifies significantly the expression of many genes involved in this process. A decrease of IGFBP6 expression can involve a decrease in the expression of N-cadherin and transcription factor Slug.
AB - Protein IGFBP6 plays an important role in the pathogenesis of many malignant tumors, including breast cancer. The relationship between IGFBP6 protein and the expression of genes associated with the epithelial-mesenchymal transition is studied. Gene IGFBP6 knockdown does not trigger the epithelial-mesenchymal transition in MDA-MB-231 cells, but modifies significantly the expression of many genes involved in this process. A decrease of IGFBP6 expression can involve a decrease in the expression of N-cadherin and transcription factor Slug.
KW - Journal Article
U2 - 10.1007/s10517-018-4051-8
DO - 10.1007/s10517-018-4051-8
M3 - SCORING: Journal article
C2 - 29577195
VL - 164
SP - 650
EP - 654
JO - B EXP BIOL MED+
JF - B EXP BIOL MED+
SN - 0007-4888
IS - 5
ER -