Right atrium size in the general population
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Right atrium size in the general population. / Keller, Karsten; Sinning, Christoph; Schulz, Andreas; Jünger, Claus; Schmitt, Volker H; Hahad, Omar; Zeller, Tanja; Beutel, Manfred; Pfeiffer, Norbert; Strauch, Konstantin; Blankenberg, Stefan; Lackner, Karl J; Prochaska, Jürgen H; Schulz, Eberhard; Münzel, Thomas; Wild, Philipp S.
in: SCI REP-UK, Jahrgang 11, Nr. 1, 22523, 18.11.2021.Publikationen: SCORING: Beitrag in Fachzeitschrift/Zeitung › SCORING: Zeitschriftenaufsatz › Forschung › Begutachtung
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TY - JOUR
T1 - Right atrium size in the general population
AU - Keller, Karsten
AU - Sinning, Christoph
AU - Schulz, Andreas
AU - Jünger, Claus
AU - Schmitt, Volker H
AU - Hahad, Omar
AU - Zeller, Tanja
AU - Beutel, Manfred
AU - Pfeiffer, Norbert
AU - Strauch, Konstantin
AU - Blankenberg, Stefan
AU - Lackner, Karl J
AU - Prochaska, Jürgen H
AU - Schulz, Eberhard
AU - Münzel, Thomas
AU - Wild, Philipp S
N1 - © 2021. The Author(s).
PY - 2021/11/18
Y1 - 2021/11/18
N2 - Echocardiography is the most common routine cardiac imaging method. Nevertheless, only few data about sex-specific reference limits for right atrium (RA) dimensions are available. Transthoracic echocardiographic RA measurements were studied in 9511 participants of the Gutenberg-Health-Study. A reference sample of 1942 cardiovascular healthy subjects without chronic obstructive pulmonary disease was defined. We assessed RA dimensions and sex-specific reference limits were defined using the 95th percentile of the reference sample. Results showed sex-specific differences with larger RA dimensions in men that were attenuated by standardization for body-height. RA-volume was 20.2 ml/m in women (5th-95th: 12.7-30.4 ml/m) and 26.1 ml/m in men (5th-95th: 16.0-40.5 ml/m). Multivariable regressions identified body-mass-index (BMI), coronary artery disease (CAD), chronic heart failure (CHF) and atrial fibrillation (AF) as independent key correlates of RA-volume in both sexes. All-cause mortality after median follow-up-period of 10.7 (9.81/11.6) years was higher in individuals who had RA volume/height outside the 95% reference limit (HR 1.70 [95%CI 1.29-2.23], P = 0.00014)). Based on a large community-based sample, we present sex-specific reference-values for RA dimensions normalized for height. RA-volume varies with BMI, CHF, CAD and AF in both sexes. Individuals with RA-volume outside the reference limit had a 1.7-fold higher mortality than those within reference limits.
AB - Echocardiography is the most common routine cardiac imaging method. Nevertheless, only few data about sex-specific reference limits for right atrium (RA) dimensions are available. Transthoracic echocardiographic RA measurements were studied in 9511 participants of the Gutenberg-Health-Study. A reference sample of 1942 cardiovascular healthy subjects without chronic obstructive pulmonary disease was defined. We assessed RA dimensions and sex-specific reference limits were defined using the 95th percentile of the reference sample. Results showed sex-specific differences with larger RA dimensions in men that were attenuated by standardization for body-height. RA-volume was 20.2 ml/m in women (5th-95th: 12.7-30.4 ml/m) and 26.1 ml/m in men (5th-95th: 16.0-40.5 ml/m). Multivariable regressions identified body-mass-index (BMI), coronary artery disease (CAD), chronic heart failure (CHF) and atrial fibrillation (AF) as independent key correlates of RA-volume in both sexes. All-cause mortality after median follow-up-period of 10.7 (9.81/11.6) years was higher in individuals who had RA volume/height outside the 95% reference limit (HR 1.70 [95%CI 1.29-2.23], P = 0.00014)). Based on a large community-based sample, we present sex-specific reference-values for RA dimensions normalized for height. RA-volume varies with BMI, CHF, CAD and AF in both sexes. Individuals with RA-volume outside the reference limit had a 1.7-fold higher mortality than those within reference limits.
U2 - 10.1038/s41598-021-01968-y
DO - 10.1038/s41598-021-01968-y
M3 - SCORING: Journal article
C2 - 34795353
VL - 11
JO - SCI REP-UK
JF - SCI REP-UK
SN - 2045-2322
IS - 1
M1 - 22523
ER -