Right Atrial Volume is Increased in Corrected Tetralogy of Fallot and Correlates with the Incidence of Supraventricular Arrhythmia
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Right Atrial Volume is Increased in Corrected Tetralogy of Fallot and Correlates with the Incidence of Supraventricular Arrhythmia : A CMR Study. / Sohns, Jan M; Rosenberg, Christina; Zapf, Antonia; Unterberg-Buchwald, Christina; Staab, Wieland; Schuster, Andreas; Kowallick, Johannes T; Hösch, Olga; Nguyen, Thuy-Trang; Fasshauer, Martin; Paul, Thomas; Lotz, Joachim; Steinmetz, Michael.
in: PEDIATR CARDIOL, Jahrgang 36, Nr. 6, 08.2015, S. 1239-1247.Publikationen: SCORING: Beitrag in Fachzeitschrift/Zeitung › SCORING: Zeitschriftenaufsatz › Forschung › Begutachtung
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TY - JOUR
T1 - Right Atrial Volume is Increased in Corrected Tetralogy of Fallot and Correlates with the Incidence of Supraventricular Arrhythmia
T2 - A CMR Study
AU - Sohns, Jan M
AU - Rosenberg, Christina
AU - Zapf, Antonia
AU - Unterberg-Buchwald, Christina
AU - Staab, Wieland
AU - Schuster, Andreas
AU - Kowallick, Johannes T
AU - Hösch, Olga
AU - Nguyen, Thuy-Trang
AU - Fasshauer, Martin
AU - Paul, Thomas
AU - Lotz, Joachim
AU - Steinmetz, Michael
PY - 2015/8
Y1 - 2015/8
N2 - The aim of this study was to evaluate right atrial (RA) volume in corrected Tetralogy of Fallot (cTOF) and assess its correlation with the occurrence of supraventricular (SV) arrhythmia. Cardiac magnetic resonance imaging (CMR) and 24-h Holter were performed in n = 67 consecutive cTOF patients (age 30 ± 11.3 years). The CMR protocol included standard HASTE, SSFP cine, and blood flow measurements. Correlations between arrhythmia in ECG, heart volume, and functional parameters were investigated by negative binominal regression. Patients' characteristics (mean ± SD) included mean RA volume of 49 ± 19 ml/m(2) (HASTE sequence), mean right ventricular (RV) end-diastolic volume of 98 ± 27 ml/m(2), mean pulmonary valve regurgitation fraction (PR) of 21 ± 19 %, BMI of 25 kg/m(2), and heart rate of 75/min. Twenty-eight out of 67 patients experienced SV arrhythmia including SV couplets or bigeminus or longer non-sustained SV tachycardia (SVT) episodes. RA volume index was identified as an independent risk factor for different degrees of SV arrhythmia (SV couplets/bigeminus p < 0.001, SVT p < 0.001). Further risk factors for SV arrhythmia were male gender (p = 0.023) and decreased left ventricular (LV) ejection fraction (EF) (LV EF p < 0.001). RA volume is increased in adult patients with cTOF with larger RA volumes relating to higher incidence of SV arrhythmia. SV arrhythmia also appeared more often in male patients and those with decreased LV EF. Risk stratification according to these parameters could help to optimize early prevention and adjusted individual therapy to improve patient outcome and quality of life.
AB - The aim of this study was to evaluate right atrial (RA) volume in corrected Tetralogy of Fallot (cTOF) and assess its correlation with the occurrence of supraventricular (SV) arrhythmia. Cardiac magnetic resonance imaging (CMR) and 24-h Holter were performed in n = 67 consecutive cTOF patients (age 30 ± 11.3 years). The CMR protocol included standard HASTE, SSFP cine, and blood flow measurements. Correlations between arrhythmia in ECG, heart volume, and functional parameters were investigated by negative binominal regression. Patients' characteristics (mean ± SD) included mean RA volume of 49 ± 19 ml/m(2) (HASTE sequence), mean right ventricular (RV) end-diastolic volume of 98 ± 27 ml/m(2), mean pulmonary valve regurgitation fraction (PR) of 21 ± 19 %, BMI of 25 kg/m(2), and heart rate of 75/min. Twenty-eight out of 67 patients experienced SV arrhythmia including SV couplets or bigeminus or longer non-sustained SV tachycardia (SVT) episodes. RA volume index was identified as an independent risk factor for different degrees of SV arrhythmia (SV couplets/bigeminus p < 0.001, SVT p < 0.001). Further risk factors for SV arrhythmia were male gender (p = 0.023) and decreased left ventricular (LV) ejection fraction (EF) (LV EF p < 0.001). RA volume is increased in adult patients with cTOF with larger RA volumes relating to higher incidence of SV arrhythmia. SV arrhythmia also appeared more often in male patients and those with decreased LV EF. Risk stratification according to these parameters could help to optimize early prevention and adjusted individual therapy to improve patient outcome and quality of life.
KW - Adolescent
KW - Adult
KW - Cardiac Volume
KW - Electrocardiography
KW - Female
KW - Heart Atria
KW - Heart Rate
KW - Heart Ventricles
KW - Humans
KW - Incidence
KW - Magnetic Resonance Imaging
KW - Male
KW - Pulmonary Valve Insufficiency
KW - Stroke Volume
KW - Tachycardia, Supraventricular
KW - Tetralogy of Fallot
KW - Ventricular Function, Right
KW - Young Adult
KW - Journal Article
KW - Research Support, Non-U.S. Gov't
U2 - 10.1007/s00246-015-1152-2
DO - 10.1007/s00246-015-1152-2
M3 - SCORING: Journal article
C2 - 25862665
VL - 36
SP - 1239
EP - 1247
JO - PEDIATR CARDIOL
JF - PEDIATR CARDIOL
SN - 0172-0643
IS - 6
ER -