Rickettsia felis Infection in Febrile Children, Ghana
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Rickettsia felis Infection in Febrile Children, Ghana. / Sothmann, Peter; Keller, Christian; Krumkamp, Ralf; Kreuels, Benno; Aldrich, Cassandra; Sarpong, Nimako; Steierberg, Stefanie; Winter, Doris; Boahen, Kennedy Gyau; Owusu-Dabo, Ellis; May, Jürgen; Eibach, Daniel.
in: AM J TROP MED HYG, Jahrgang 96, Nr. 4, 04.2017, S. 783-785.Publikationen: SCORING: Beitrag in Fachzeitschrift/Zeitung › SCORING: Zeitschriftenaufsatz › Forschung › Begutachtung
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TY - JOUR
T1 - Rickettsia felis Infection in Febrile Children, Ghana
AU - Sothmann, Peter
AU - Keller, Christian
AU - Krumkamp, Ralf
AU - Kreuels, Benno
AU - Aldrich, Cassandra
AU - Sarpong, Nimako
AU - Steierberg, Stefanie
AU - Winter, Doris
AU - Boahen, Kennedy Gyau
AU - Owusu-Dabo, Ellis
AU - May, Jürgen
AU - Eibach, Daniel
PY - 2017/4
Y1 - 2017/4
N2 - AbstractRickettsial infections are an underrecognized cause of febrile illness in sub-Saharan Africa. To evaluate the epidemiology and clinical features of rickettsial disease in pediatric patients in Ghana, we screened blood samples from febrile children aged less than 15 years presenting to an outpatient department in Ghana's Ashanti Region for the presence of rickettsial DNA. We detectedRickettsia felisin 7/470 (1.5%) blood samples, using two independent real-time polymerase chain reactions. No otherRickettsiaspecies were found.R. feliswas detected repeatedly in one patient, and coinfection withPlasmodium falciparumwas found in 3/7 samples. Symptoms apart from fever included cough (6/7) and vomiting (4/7). None of theR. felis-positive patients reported a rash. This study is the first report onR. felisin Ghana and adds to the growing evidence for its widespread occurrence with and without malaria coinfection in sub-Saharan Africa.
AB - AbstractRickettsial infections are an underrecognized cause of febrile illness in sub-Saharan Africa. To evaluate the epidemiology and clinical features of rickettsial disease in pediatric patients in Ghana, we screened blood samples from febrile children aged less than 15 years presenting to an outpatient department in Ghana's Ashanti Region for the presence of rickettsial DNA. We detectedRickettsia felisin 7/470 (1.5%) blood samples, using two independent real-time polymerase chain reactions. No otherRickettsiaspecies were found.R. feliswas detected repeatedly in one patient, and coinfection withPlasmodium falciparumwas found in 3/7 samples. Symptoms apart from fever included cough (6/7) and vomiting (4/7). None of theR. felis-positive patients reported a rash. This study is the first report onR. felisin Ghana and adds to the growing evidence for its widespread occurrence with and without malaria coinfection in sub-Saharan Africa.
KW - Anti-Bacterial Agents
KW - Antimalarials
KW - Artemisinins
KW - Child
KW - Female
KW - Ghana
KW - Humans
KW - Infant
KW - Malaria, Falciparum
KW - Male
KW - Rickettsia Infections
KW - Rickettsia felis
KW - Journal Article
U2 - 10.4269/ajtmh.16-0754
DO - 10.4269/ajtmh.16-0754
M3 - SCORING: Journal article
C2 - 28115672
VL - 96
SP - 783
EP - 785
JO - AM J TROP MED HYG
JF - AM J TROP MED HYG
SN - 0002-9637
IS - 4
ER -