Remission of severely impaired subjective wellbeing in 727 patients with schizophrenia treated with amisulpride.
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Remission of severely impaired subjective wellbeing in 727 patients with schizophrenia treated with amisulpride. / Lambert, Martin; Naber, Dieter; Eich, F X; Schacht, M; Linden, M; Schimmelmann, Benno Graf.
in: ACTA PSYCHIAT SCAND, Jahrgang 115, Nr. 2, 2, 2007, S. 106-113.Publikationen: SCORING: Beitrag in Fachzeitschrift/Zeitung › SCORING: Zeitschriftenaufsatz › Forschung › Begutachtung
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TY - JOUR
T1 - Remission of severely impaired subjective wellbeing in 727 patients with schizophrenia treated with amisulpride.
AU - Lambert, Martin
AU - Naber, Dieter
AU - Eich, F X
AU - Schacht, M
AU - Linden, M
AU - Schimmelmann, Benno Graf
PY - 2007
Y1 - 2007
N2 - Studies of subjective wellbeing (SW) in schizophrenia have missed to define and to assess rate and predictors of SW response (SW-res) and SW remission (SW-rem). METHOD: A total of 727 patients with schizophrenia and severely impaired SW at entry (Subjective Wellbeing under Neuroleptics Scale, short version, SWN-K, total score or =80 points. RESULTS: Seventy percent fulfilled the SW-res criterion at week 4. At week 4 and week 12 (endpoint), the SW response criterion distinguished between patients with or without later SW remission and overall symptomatic and functional response. While 39% fulfilled the SW-rem criterion at endpoint, only 9.1% without early SW-res were in SW-rem at follow-up. Regression analyses indicated that SW-res was mainly predicted by greater severity of positive symptoms at baseline and SW-rem by lower severity of negative symptoms and better social functioning, and particularly by early SW-res. CONCLUSION: Patients with a risk of SW non-remission need to be identified early with subsequent treatment adaptation according to recommendations for incomplete remission and treatment resistance in schizophrenia.
AB - Studies of subjective wellbeing (SW) in schizophrenia have missed to define and to assess rate and predictors of SW response (SW-res) and SW remission (SW-rem). METHOD: A total of 727 patients with schizophrenia and severely impaired SW at entry (Subjective Wellbeing under Neuroleptics Scale, short version, SWN-K, total score or =80 points. RESULTS: Seventy percent fulfilled the SW-res criterion at week 4. At week 4 and week 12 (endpoint), the SW response criterion distinguished between patients with or without later SW remission and overall symptomatic and functional response. While 39% fulfilled the SW-rem criterion at endpoint, only 9.1% without early SW-res were in SW-rem at follow-up. Regression analyses indicated that SW-res was mainly predicted by greater severity of positive symptoms at baseline and SW-rem by lower severity of negative symptoms and better social functioning, and particularly by early SW-res. CONCLUSION: Patients with a risk of SW non-remission need to be identified early with subsequent treatment adaptation according to recommendations for incomplete remission and treatment resistance in schizophrenia.
M3 - SCORING: Zeitschriftenaufsatz
VL - 115
SP - 106
EP - 113
JO - ACTA PSYCHIAT SCAND
JF - ACTA PSYCHIAT SCAND
SN - 0001-690X
IS - 2
M1 - 2
ER -