Reduced synchronization in the visual cortex of cats with strabismic amblyopia
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Reduced synchronization in the visual cortex of cats with strabismic amblyopia. / Roelfsema, P R; König, P; Engel, A K; Sireteanu, R; Singer, W.
in: EUR J NEUROSCI, Jahrgang 6, Nr. 11, 01.11.1994, S. 1645-55.Publikationen: SCORING: Beitrag in Fachzeitschrift/Zeitung › SCORING: Zeitschriftenaufsatz › Forschung › Begutachtung
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TY - JOUR
T1 - Reduced synchronization in the visual cortex of cats with strabismic amblyopia
AU - Roelfsema, P R
AU - König, P
AU - Engel, A K
AU - Sireteanu, R
AU - Singer, W
PY - 1994/11/1
Y1 - 1994/11/1
N2 - Synchronous firing of spatially separate neurons was studied with multi-electrode recordings in area 17 of the visual cortex of strabismic cats which had developed behaviourally verified amblyopia of the deviated eye. Responses of neurons were evoked with moving light bars or gratings of different spatial frequency. Neurons driven by the normal eye displayed stronger synchronization of their responses than neurons dominated by the amblyopic eye. These interocular differences were highly significant and particularly pronounced for grating stimuli of high spatial frequency. No interocular differences were noted with respect to the amplitudes of responses to the light bars and gratings. These results suggest reduced synchronization of population responses as a neurophysiological correlate of strabismic amblyopia and underline the importance of correlated firing of spatially separate cortical neurons for normal processing of visual information.
AB - Synchronous firing of spatially separate neurons was studied with multi-electrode recordings in area 17 of the visual cortex of strabismic cats which had developed behaviourally verified amblyopia of the deviated eye. Responses of neurons were evoked with moving light bars or gratings of different spatial frequency. Neurons driven by the normal eye displayed stronger synchronization of their responses than neurons dominated by the amblyopic eye. These interocular differences were highly significant and particularly pronounced for grating stimuli of high spatial frequency. No interocular differences were noted with respect to the amplitudes of responses to the light bars and gratings. These results suggest reduced synchronization of population responses as a neurophysiological correlate of strabismic amblyopia and underline the importance of correlated firing of spatially separate cortical neurons for normal processing of visual information.
KW - Amblyopia
KW - Animals
KW - Behavior, Animal
KW - Brain Mapping
KW - Cats
KW - Cortical Synchronization
KW - Electrophysiology
KW - Functional Laterality
KW - Oculomotor Muscles
KW - Orientation
KW - Photic Stimulation
KW - Reflex
KW - Strabismus
KW - Visual Cortex
M3 - SCORING: Journal article
C2 - 7874303
VL - 6
SP - 1645
EP - 1655
JO - EUR J NEUROSCI
JF - EUR J NEUROSCI
SN - 0953-816X
IS - 11
ER -