Reduced membranous MET expression is linked to bladder cancer progression
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Reduced membranous MET expression is linked to bladder cancer progression. / Kluth, Martina; Reynolds, Kristina; Rink, Michael; Chun, Felix; Dahlem, Roland; Fisch, Margit; Höppner, Wolfgang; Wagner, Walter; Doh, Ousman; Terracciano, Luigi; Simon, Ronald; Sauter, Guido; Minner, Sarah.
in: CANCER GENET-NY, Jahrgang 207, Nr. 4, 01.04.2014, S. 147-52.Publikationen: SCORING: Beitrag in Fachzeitschrift/Zeitung › SCORING: Zeitschriftenaufsatz › Forschung › Begutachtung
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TY - JOUR
T1 - Reduced membranous MET expression is linked to bladder cancer progression
AU - Kluth, Martina
AU - Reynolds, Kristina
AU - Rink, Michael
AU - Chun, Felix
AU - Dahlem, Roland
AU - Fisch, Margit
AU - Höppner, Wolfgang
AU - Wagner, Walter
AU - Doh, Ousman
AU - Terracciano, Luigi
AU - Simon, Ronald
AU - Sauter, Guido
AU - Minner, Sarah
N1 - Copyright © 2014 Elsevier Inc. All rights reserved.
PY - 2014/4/1
Y1 - 2014/4/1
N2 - The MET protein is involved in the malignant progression of different tumors. This study aimed to analyze the relationship of MET expression with tumor phenotype and clinical outcome in bladder cancer and the role of gene amplification for MET overexpression. A bladder cancer tissue microarray containing 686 bladder cancers was analyzed by immunohistochemistry and by fluorescence in situ hybridization. MET immunostaining was seen in normal urothelium and was recorded in 459 of 560 analyzable urothelial carcinomas (82.0%). Low MET staining was associated with a more unfavorable tumor phenotype. MET staining was seen in 89.8% of 266 pTa, 81.1% of 132 pT1, and 69.4% of 160 pT2-4 cancers (P < 0.0001). MET staining was detectable in 92.4% of 66 grade 1, 85.6% of 257 grade 2, and 75.1% of 237 grade 3 cancers (P = 0.001). MET expression status was not associated with overall or tumor-specific survival in muscle-invasive cancers (pT2-4), tumor progression in pT1 cancers, or recurrences in pTa tumors. Only four of the analyzed tumors (0.8%) showed amplification of the MET gene. We conclude that MET is not overexpressed in urothelial cancer but rather downregulated in a fraction of cancers. Accordingly, rare amplification of the genomic area including the MET gene was not associated with MET protein overexpression.
AB - The MET protein is involved in the malignant progression of different tumors. This study aimed to analyze the relationship of MET expression with tumor phenotype and clinical outcome in bladder cancer and the role of gene amplification for MET overexpression. A bladder cancer tissue microarray containing 686 bladder cancers was analyzed by immunohistochemistry and by fluorescence in situ hybridization. MET immunostaining was seen in normal urothelium and was recorded in 459 of 560 analyzable urothelial carcinomas (82.0%). Low MET staining was associated with a more unfavorable tumor phenotype. MET staining was seen in 89.8% of 266 pTa, 81.1% of 132 pT1, and 69.4% of 160 pT2-4 cancers (P < 0.0001). MET staining was detectable in 92.4% of 66 grade 1, 85.6% of 257 grade 2, and 75.1% of 237 grade 3 cancers (P = 0.001). MET expression status was not associated with overall or tumor-specific survival in muscle-invasive cancers (pT2-4), tumor progression in pT1 cancers, or recurrences in pTa tumors. Only four of the analyzed tumors (0.8%) showed amplification of the MET gene. We conclude that MET is not overexpressed in urothelial cancer but rather downregulated in a fraction of cancers. Accordingly, rare amplification of the genomic area including the MET gene was not associated with MET protein overexpression.
U2 - 10.1016/j.cancergen.2014.03.008
DO - 10.1016/j.cancergen.2014.03.008
M3 - SCORING: Journal article
C2 - 24853099
VL - 207
SP - 147
EP - 152
JO - CANCER GENET-NY
JF - CANCER GENET-NY
SN - 2210-7762
IS - 4
ER -
