Pubertal maturation and sex effects on the default-mode network connectivity implicated in mood dysregulation

TY - JOUR

T1 - Pubertal maturation and sex effects on the default-mode network connectivity implicated in mood dysregulation

AU - Ernst, Monique

AU - Benson, Brenda

AU - Artiges, Eric

AU - Gorka, Adam X

AU - Lemaitre, Herve

AU - Lago, Tiffany

AU - Miranda, Ruben

AU - Banaschewski, Tobias

AU - Bokde, Arun L W

AU - Bromberg, Uli

AU - Brühl, Rüdiger

AU - Büchel, Christian

AU - Cattrell, Anna

AU - Conrod, Patricia

AU - Desrivières, Sylvane

AU - Fadai, Tahmine

AU - Flor, Herta

AU - Grigis, Antoine

AU - Gallinat, Juergen

AU - Garavan, Hugh

AU - Gowland, Penny

AU - Grimmer, Yvonne

AU - Heinz, Andreas

AU - Kappel, Viola

AU - Nees, Frauke

AU - Papadopoulos-Orfanos, Dimitri

AU - Penttilä, Jani

AU - Poustka, Luise

AU - Smolka, Michael N

AU - Stringaris, Argyris

AU - Struve, Maren

AU - van Noort, Betteke M

AU - Walter, Henrik

AU - Whelan, Robert

AU - Schumann, Gunter

AU - Grillon, Christian

AU - Martinot, Marie-Laure Paillère

AU - Martinot, Jean-Luc

AU - IMAGEN Consortium

PY - 2019/2/25

Y1 - 2019/2/25

N2 - This study examines the effects of puberty and sex on the intrinsic functional connectivity (iFC) of brain networks, with a focus on the default-mode network (DMN). Consistently implicated in depressive disorders, the DMN's function may interact with puberty and sex in the development of these disorders, whose onsets peak in adolescence, and which show strong sex disproportionality (females > males). The main question concerns how the DMN evolves with puberty as a function of sex. These effects are expected to involve within- and between-network iFC, particularly, the salience and the central-executive networks, consistent with the Triple-Network Model. Resting-state scans of an adolescent community sample (n = 304, male/female: 157/147; mean/std age: 14.6/0.41 years), from the IMAGEN database, were analyzed using the AFNI software suite and a data reduction strategy for the effects of puberty and sex. Three midline regions (medial prefrontal, pregenual anterior cingulate, and posterior cingulate), within the DMN and consistently implicated in mood disorders, were selected as seeds. Within- and between-network clusters of the DMN iFC changed with pubertal maturation differently in boys and girls (puberty-X-sex). Specifically, pubertal maturation predicted weaker iFC in girls and stronger iFC in boys. Finally, iFC was stronger in boys than girls independently of puberty. Brain-behavior associations indicated that lower connectivity of the anterior cingulate seed predicted higher internalizing symptoms at 2-year follow-up. In conclusion, weaker iFC of the anterior DMN may signal disconnections among circuits supporting mood regulation, conferring risk for internalizing disorders.

AB - This study examines the effects of puberty and sex on the intrinsic functional connectivity (iFC) of brain networks, with a focus on the default-mode network (DMN). Consistently implicated in depressive disorders, the DMN's function may interact with puberty and sex in the development of these disorders, whose onsets peak in adolescence, and which show strong sex disproportionality (females > males). The main question concerns how the DMN evolves with puberty as a function of sex. These effects are expected to involve within- and between-network iFC, particularly, the salience and the central-executive networks, consistent with the Triple-Network Model. Resting-state scans of an adolescent community sample (n = 304, male/female: 157/147; mean/std age: 14.6/0.41 years), from the IMAGEN database, were analyzed using the AFNI software suite and a data reduction strategy for the effects of puberty and sex. Three midline regions (medial prefrontal, pregenual anterior cingulate, and posterior cingulate), within the DMN and consistently implicated in mood disorders, were selected as seeds. Within- and between-network clusters of the DMN iFC changed with pubertal maturation differently in boys and girls (puberty-X-sex). Specifically, pubertal maturation predicted weaker iFC in girls and stronger iFC in boys. Finally, iFC was stronger in boys than girls independently of puberty. Brain-behavior associations indicated that lower connectivity of the anterior cingulate seed predicted higher internalizing symptoms at 2-year follow-up. In conclusion, weaker iFC of the anterior DMN may signal disconnections among circuits supporting mood regulation, conferring risk for internalizing disorders.

U2 - 10.1038/s41398-019-0433-6

DO - 10.1038/s41398-019-0433-6

M3 - SCORING: Journal article

C2 - 30804326

VL - 9

SP - 103

JO - TRANSL PSYCHIAT

JF - TRANSL PSYCHIAT

SN - 2158-3188

IS - 1

ER -