Psychoneuroendocrine stress response may impair neutrophil function in complex regional pain syndrome.
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Psychoneuroendocrine stress response may impair neutrophil function in complex regional pain syndrome. / Kaufmann, Ines; Eisner, Christoph; Richter, Hans Peter; Huge, Volker; Beyer, Antje; Chouker, Alexander; Schelling, Gustav; Thiel, Manfred.
in: CLIN IMMUNOL, Jahrgang 125, Nr. 1, 1, 2007, S. 103-111.Publikationen: SCORING: Beitrag in Fachzeitschrift/Zeitung › SCORING: Zeitschriftenaufsatz › Forschung › Begutachtung
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TY - JOUR
T1 - Psychoneuroendocrine stress response may impair neutrophil function in complex regional pain syndrome.
AU - Kaufmann, Ines
AU - Eisner, Christoph
AU - Richter, Hans Peter
AU - Huge, Volker
AU - Beyer, Antje
AU - Chouker, Alexander
AU - Schelling, Gustav
AU - Thiel, Manfred
PY - 2007
Y1 - 2007
N2 - In order to elucidate the interaction between pain, stress and innate immunity in complex regional pain syndrome (CRPS), we assessed pain and stress levels in CRPS patients and compared ex vivo functions of neutrophils between patients with CRPS and healthy volunteers. As compared with healthy volunteers, the following major alterations in CRPS patients were found: (I) elevated stress score (PTSS-10) and stress hormone concentrations, (II) decreased expression of the CD62L and CD11b/CD18 on neutrophils, (III) impaired ability of autologous plasma to enhance the capability of neutrophils to phagocytose zymosan particles, and (IV) a negative correlation between PTSS-10 values and autologous plasma enhanced phagocytosis. In vitro incubation of neutrophils with catecholamines decreased phagocytosis of zymosan. In conclusion, CRPS patients exhibit signs of impaired innate immunity which might reflect the immunological consequence of an immunosuppressive neuroendocrine stress response.
AB - In order to elucidate the interaction between pain, stress and innate immunity in complex regional pain syndrome (CRPS), we assessed pain and stress levels in CRPS patients and compared ex vivo functions of neutrophils between patients with CRPS and healthy volunteers. As compared with healthy volunteers, the following major alterations in CRPS patients were found: (I) elevated stress score (PTSS-10) and stress hormone concentrations, (II) decreased expression of the CD62L and CD11b/CD18 on neutrophils, (III) impaired ability of autologous plasma to enhance the capability of neutrophils to phagocytose zymosan particles, and (IV) a negative correlation between PTSS-10 values and autologous plasma enhanced phagocytosis. In vitro incubation of neutrophils with catecholamines decreased phagocytosis of zymosan. In conclusion, CRPS patients exhibit signs of impaired innate immunity which might reflect the immunological consequence of an immunosuppressive neuroendocrine stress response.
M3 - SCORING: Zeitschriftenaufsatz
VL - 125
SP - 103
EP - 111
JO - CLIN IMMUNOL
JF - CLIN IMMUNOL
SN - 1521-6616
IS - 1
M1 - 1
ER -