Prevalence and prognostic impact of allelic imbalances associated with leukemic transformation of Philadelphia chromosome-negative myeloproliferative neoplasms.
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Prevalence and prognostic impact of allelic imbalances associated with leukemic transformation of Philadelphia chromosome-negative myeloproliferative neoplasms. / Thoennissen, Nils H; Krug, Utz O; Lee, Dhong Hyun Tony; Kawamata, Norihiko; Iwanski, Gabriela; Lasho, Terra; Weiss, Tamara; Nowak, Daniel; Koren-Michowitz, Maya; Kato, Motohiro; Sanada, Masashi; Shih, Lee-Yung; Nagler, Arnon; Raynaud, Sophie D; Muller-Tidow, Carsten; Mesa, Ruben; Haferlach, Torsten; Gilliland, D Gary; Tefferi, Ayalew; Ogawa, Seishi; Koeffler, H Phillip.
in: BLOOD, Jahrgang 115, Nr. 14, 14, 2010, S. 2882-2890.Publikationen: SCORING: Beitrag in Fachzeitschrift/Zeitung › SCORING: Zeitschriftenaufsatz › Forschung › Begutachtung
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T1 - Prevalence and prognostic impact of allelic imbalances associated with leukemic transformation of Philadelphia chromosome-negative myeloproliferative neoplasms.
AU - Thoennissen, Nils H
AU - Krug, Utz O
AU - Lee, Dhong Hyun Tony
AU - Kawamata, Norihiko
AU - Iwanski, Gabriela
AU - Lasho, Terra
AU - Weiss, Tamara
AU - Nowak, Daniel
AU - Koren-Michowitz, Maya
AU - Kato, Motohiro
AU - Sanada, Masashi
AU - Shih, Lee-Yung
AU - Nagler, Arnon
AU - Raynaud, Sophie D
AU - Muller-Tidow, Carsten
AU - Mesa, Ruben
AU - Haferlach, Torsten
AU - Gilliland, D Gary
AU - Tefferi, Ayalew
AU - Ogawa, Seishi
AU - Koeffler, H Phillip
PY - 2010
Y1 - 2010
N2 - Philadelphia-chromosome negative myeloproliferative neoplasms (MPNs) including polycythemia vera, essential thrombocythemia and primary myelofibrosis show an inherent tendency for transformation into leukemia (MPN-blast phase), which is hypothesized to be accompanied by acquisition of additional genomic lesions. We, therefore, examined chromosomal abnormalities by high-resolution single-nucleotide polymorphism (SNP) array in 88 MPN patients, as well as 71 cases with MPN-blast phase, and correlated these findings with their clinical parameters. Frequent genomic alterations were found in MPN after leukemic transformation with up to 3-fold more genomic changes per sample compared to samples in chronic phase (p
AB - Philadelphia-chromosome negative myeloproliferative neoplasms (MPNs) including polycythemia vera, essential thrombocythemia and primary myelofibrosis show an inherent tendency for transformation into leukemia (MPN-blast phase), which is hypothesized to be accompanied by acquisition of additional genomic lesions. We, therefore, examined chromosomal abnormalities by high-resolution single-nucleotide polymorphism (SNP) array in 88 MPN patients, as well as 71 cases with MPN-blast phase, and correlated these findings with their clinical parameters. Frequent genomic alterations were found in MPN after leukemic transformation with up to 3-fold more genomic changes per sample compared to samples in chronic phase (p
M3 - SCORING: Zeitschriftenaufsatz
VL - 115
SP - 2882
EP - 2890
JO - BLOOD
JF - BLOOD
SN - 0006-4971
IS - 14
M1 - 14
ER -