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Pregnancy Galectinology

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Pregnancy Galectinology : Insights Into a Complex Network of Glycan Binding Proteins. / Blois, Sandra M; Dveksler, Gabriela; Vasta, Gerardo R; Freitag, Nancy; Blanchard, Véronique; Barrientos, Gabriela.

in: FRONT IMMUNOL, Jahrgang 10, 2019, S. 1166.

Publikationen: SCORING: Beitrag in Fachzeitschrift/Zeitung › SCORING: Review › Forschung

Harvard

Blois, SM, Dveksler, G, Vasta, GR, Freitag, N, Blanchard, V & Barrientos, G 2019, 'Pregnancy Galectinology: Insights Into a Complex Network of Glycan Binding Proteins', FRONT IMMUNOL, Jg. 10, S. 1166. https://doi.org/10.3389/fimmu.2019.01166

APA

Blois, S. M., Dveksler, G., Vasta, G. R., Freitag, N., Blanchard, V., & Barrientos, G. (2019). Pregnancy Galectinology: Insights Into a Complex Network of Glycan Binding Proteins. FRONT IMMUNOL, 10, 1166. https://doi.org/10.3389/fimmu.2019.01166

Vancouver

Blois SM, Dveksler G, Vasta GR, Freitag N, Blanchard V, Barrientos G. Pregnancy Galectinology: Insights Into a Complex Network of Glycan Binding Proteins. FRONT IMMUNOL. 2019;10:1166. https://doi.org/10.3389/fimmu.2019.01166

Bibtex

@article{68c937b8905e42429166f1142998dada,
title = "Pregnancy Galectinology: Insights Into a Complex Network of Glycan Binding Proteins",
abstract = "Galectins are a phylogenetically conserved family of soluble β-galactoside binding proteins, consisting of 15 different types, each with a specific function. Galectins contribute to placentation by regulating trophoblast development, migration, and invasion during early pregnancy. In addition, galectins are critical players regulating maternal immune tolerance to the embedded embryo. Recently, the role of galectins in angiogenesis during decidualization and in placenta formation has gained attention. Altered expression of galectins is associated with abnormal pregnancies and infertility. This review focuses on the role of galectins in pregnancy-associated processes and discusses the relevance of galectin-glycan interactions as potential therapeutic targets in pregnancy disorders.",
keywords = "Animals, Carbohydrate Sequence, Chromosome Mapping, Dimerization, Embryo, Nonmammalian/metabolism, Embryonic Development/physiology, Endothelial Cells/metabolism, Extracellular Vesicles/metabolism, Female, Galectins/chemistry, Glycosylation, Humans, Maternal-Fetal Exchange/physiology, Neovascularization, Physiologic/physiology, Placentation/physiology, Polysaccharides/chemistry, Pre-Eclampsia/metabolism, Pregnancy, Pregnancy Proteins/physiology, Protein Processing, Post-Translational, Structure-Activity Relationship, Substrate Specificity, Trophoblasts/metabolism",
author = "Blois, {Sandra M} and Gabriela Dveksler and Vasta, {Gerardo R} and Nancy Freitag and V{\'e}ronique Blanchard and Gabriela Barrientos",
year = "2019",
doi = "10.3389/fimmu.2019.01166",
language = "English",
volume = "10",
pages = "1166",
journal = "FRONT IMMUNOL",
issn = "1664-3224",
publisher = "Lausanne : Frontiers Research Foundation",

}

RIS

TY - JOUR

T1 - Pregnancy Galectinology

T2 - Insights Into a Complex Network of Glycan Binding Proteins

AU - Blois, Sandra M

AU - Dveksler, Gabriela

AU - Vasta, Gerardo R

AU - Freitag, Nancy

AU - Blanchard, Véronique

AU - Barrientos, Gabriela

PY - 2019

Y1 - 2019

N2 - Galectins are a phylogenetically conserved family of soluble β-galactoside binding proteins, consisting of 15 different types, each with a specific function. Galectins contribute to placentation by regulating trophoblast development, migration, and invasion during early pregnancy. In addition, galectins are critical players regulating maternal immune tolerance to the embedded embryo. Recently, the role of galectins in angiogenesis during decidualization and in placenta formation has gained attention. Altered expression of galectins is associated with abnormal pregnancies and infertility. This review focuses on the role of galectins in pregnancy-associated processes and discusses the relevance of galectin-glycan interactions as potential therapeutic targets in pregnancy disorders.

AB - Galectins are a phylogenetically conserved family of soluble β-galactoside binding proteins, consisting of 15 different types, each with a specific function. Galectins contribute to placentation by regulating trophoblast development, migration, and invasion during early pregnancy. In addition, galectins are critical players regulating maternal immune tolerance to the embedded embryo. Recently, the role of galectins in angiogenesis during decidualization and in placenta formation has gained attention. Altered expression of galectins is associated with abnormal pregnancies and infertility. This review focuses on the role of galectins in pregnancy-associated processes and discusses the relevance of galectin-glycan interactions as potential therapeutic targets in pregnancy disorders.

KW - Animals

KW - Carbohydrate Sequence

KW - Chromosome Mapping

KW - Dimerization

KW - Embryo, Nonmammalian/metabolism

KW - Embryonic Development/physiology

KW - Endothelial Cells/metabolism

KW - Extracellular Vesicles/metabolism

KW - Female

KW - Galectins/chemistry

KW - Glycosylation

KW - Humans

KW - Maternal-Fetal Exchange/physiology

KW - Neovascularization, Physiologic/physiology

KW - Placentation/physiology

KW - Polysaccharides/chemistry

KW - Pre-Eclampsia/metabolism

KW - Pregnancy

KW - Pregnancy Proteins/physiology

KW - Protein Processing, Post-Translational

KW - Structure-Activity Relationship

KW - Substrate Specificity

KW - Trophoblasts/metabolism

U2 - 10.3389/fimmu.2019.01166

DO - 10.3389/fimmu.2019.01166

M3 - SCORING: Review article

C2 - 31231368

VL - 10

SP - 1166

JO - FRONT IMMUNOL

JF - FRONT IMMUNOL

SN - 1664-3224

ER -